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Protein

RNA-binding protein Hfq

Gene

hfq

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.UniRule annotation

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1139-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein HfqUniRule annotation
Gene namesi
Name:hfqUniRule annotation
Ordered Locus Names:BruAb1_1117
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878RNA-binding protein HfqPRO_0000095627Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_1117.

Structurei

3D structure databases

ProteinModelPortaliP0C107.
SMRiP0C107. Positions 7-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Hfq family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1923.
HOGENOMiHOG000004931.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERSQNLQD LFLNSVRKQK ISLTIFLING VKLTGIVTSF DNFCVLLRRD
60 70
GHSQLVYKHA ISTIMPSQPV QMFEGEEA
Length:78
Mass (Da):8,854
Last modified:February 7, 2006 - v1
Checksum:i0D27DBD9CA161BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74458.1.
RefSeqiYP_221819.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74458; AAX74458; BruAb1_1117.
KEGGibmb:BruAb1_1117.
PATRICi17823923. VBIBruAbo15061_1184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74458.1.
RefSeqiYP_221819.1. NC_006932.1.

3D structure databases

ProteinModelPortaliP0C107.
SMRiP0C107. Positions 7-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_1117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX74458; AAX74458; BruAb1_1117.
KEGGibmb:BruAb1_1117.
PATRICi17823923. VBIBruAbo15061_1184.

Phylogenomic databases

eggNOGiCOG1923.
HOGENOMiHOG000004931.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1139-MONOMER.

Miscellaneous databases

PROiP0C107.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiHFQ_BRUAB
AccessioniPrimary (citable) accession number: P0C107
Secondary accession number(s): P0A3G9, Q57D26, Q9XBW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: April 1, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.