Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C104 (FABZ_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

EC=4.2.1.59
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name=(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase
Gene names
Name:fabZ
Ordered Locus Names:BruAb1_1158
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity. HAMAP-Rule MF_00406

Catalytic activity

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O. HAMAP-Rule MF_00406

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00406.

Sequence similarities

Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

lipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1571573-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ HAMAP-Rule MF_00406
PRO_0000091649

Sites

Active site581 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C104 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 53797D7B16126103

FASTA15717,214
        10         20         30         40         50         60 
MSDDNQTKLE AADIQALLAV LPHRYPFLLI DRIVDIDGDV SATGIKNVTI NEPHFTGHFP 

        70         80         90        100        110        120 
ENPIMPGVLI VEAMAQTAGA ISLLQRKTGR PGVVYFMTID NAKFRRPVVP GDRLLLYVKK 

       130        140        150 
IKQRANISKY ECVAEVDGVK VAEAEVAAMI SVADENL 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX74497.1.
RefSeqYP_221858.1. NC_006932.1.

3D structure databases

ProteinModelPortalP0C104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX74497; AAX74497; BruAb1_1158.
GeneID3341060.
KEGGbmb:BruAb1_1158.
PATRIC17824004. VBIBruAbo15061_1224.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0764.
HOGENOMHOG000277829.
KOK02372.
OMATIRSENM.
OrthoDBEOG6JTCGM.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1180-MONOMER.

Family and domain databases

Gene3D3.10.129.10. 1 hit.
HAMAPMF_00406. FabZ.
InterProIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMSSF54637. SSF54637. 1 hit.
TIGRFAMsTIGR01750. fabZ. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABZ_BRUAB
AccessionPrimary (citable) accession number: P0C104
Secondary accession number(s): Q44631, Q57CY7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names