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P0C104

- FABZ_BRUAB

UniProt

P0C104 - FABZ_BRUAB

Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581UniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1180-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
    Alternative name(s):
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
    Short name:
    (3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
    Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
    Gene namesi
    Name:fabZUniRule annotation
    Ordered Locus Names:BruAb1_1158
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1571573-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000091649Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1158.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0764.
    HOGENOMiHOG000277829.
    KOiK02372.
    OMAiTIRSENM.
    OrthoDBiEOG6JTCGM.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00406. FabZ.
    InterProiIPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01750. fabZ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDDNQTKLE AADIQALLAV LPHRYPFLLI DRIVDIDGDV SATGIKNVTI    50
    NEPHFTGHFP ENPIMPGVLI VEAMAQTAGA ISLLQRKTGR PGVVYFMTID 100
    NAKFRRPVVP GDRLLLYVKK IKQRANISKY ECVAEVDGVK VAEAEVAAMI 150
    SVADENL 157
    Length:157
    Mass (Da):17,214
    Last modified:February 7, 2006 - v1
    Checksum:i53797D7B16126103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74497.1.
    RefSeqiYP_221858.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74497; AAX74497; BruAb1_1158.
    GeneIDi3341060.
    KEGGibmb:BruAb1_1158.
    PATRICi17824004. VBIBruAbo15061_1224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74497.1 .
    RefSeqi YP_221858.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali P0C104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74497 ; AAX74497 ; BruAb1_1158 .
    GeneIDi 3341060.
    KEGGi bmb:BruAb1_1158.
    PATRICi 17824004. VBIBruAbo15061_1224.

    Phylogenomic databases

    eggNOGi COG0764.
    HOGENOMi HOG000277829.
    KOi K02372.
    OMAi TIRSENM.
    OrthoDBi EOG6JTCGM.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-1180-MONOMER.

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00406. FabZ.
    InterProi IPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01750. fabZ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiFABZ_BRUAB
    AccessioniPrimary (citable) accession number: P0C104
    Secondary accession number(s): Q44631, Q57CY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3