Reviewed, UniProtKB/Swiss-Prot P0C102 (CDSA_BRUAB)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	BruAb1_1163

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Phosphatidate cytidylyltransferase		PRO_0000090727
Regions
	Transmembrane	19 – 39	21	Potential
	Transmembrane	53 – 73	21	Potential
	Transmembrane	76 – 96	21	Potential
	Transmembrane	101 – 121	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	248 – 268	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P0C102-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 47F253043415FF06	FASTA	270	28,448
	10 20 30 40 50 60 MSNLQTRIIT AIVLGTITLW LTWVGGVGFT LFSIAIGLAM FYEWTELSAT RQTAFSRLFG 70 80 90 100 110 120 WAWLIVTGIL LILDRGALLT IGFLVAGCAI LLVTQWKSGR GWPAAGLFYA GFSALSLSLL 130 140 150 160 170 180 RGDEPFGFTT IVFLFAVVWS TDITAYFNGR ALGGPKLAPR FSPNKTWSGA IGGAAAAVAG 190 200 210 220 230 240 GLLVASLVAA PGGWGVPVLA LLLSIVSQIG DLAESWVKRQ FGAKDSGRLL PGHGGVLDRV 250 260 270 DGLVAAAALL YLFGAIFAEP DVLSAIFFSF

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX74502.1.
RefSeq	YP_221863.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339837.
GenomeReviews	Gene locus BruAb1_1163 in contig AE017223_GR.
KEGG	bmb:BruAb1_1163.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0C102.
OMA	YEWITIT.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_1163-MON.
BRENDA	2.7.7.41. 575.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_BRUAB

Accession

Primary (citable) accession number: P0C102
Secondary accession number(s): Q57CY2, Q59173

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)