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Protein

60 kDa chaperonin

Gene

groL

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). This protein is implicated in the pathogenesis of chlamydial disease. Inflammation elicited by the 57 kDa antigen may damage tissue, with progression to scarring of conjunctival and fallopian tube mucosae, which respectively result in blindness and infertility.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
57 kDa chlamydial hypersensitivity antigen
GroEL proteinUniRule annotation
Heat shock protein 60
Short name:
HSP60
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, hypB, mopA
Ordered Locus Names:CT_110
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000633322 – 54460 kDa chaperoninAdd BLAST543

Expressioni

Inductioni

By stress.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ROJmodel-B-[»]
1ROKmodel-B-[»]
ProteinModelPortaliP0C0Z7.
SMRiP0C0Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
InParanoidiP0C0Z7.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKNIKYNE EARKKIQKGV KTLAEAVKVT LGPKGRHVVI DKSFGSPQVT
60 70 80 90 100
KDGVTVAKEV ELADKHENMG AQMVKEVASK TADKAGDGTT TATVLAEAIY
110 120 130 140 150
TEGLRNVTAG ANPMDLKRGI DKAVKVVVDQ IRKISKPVQH HKEIAQVATI
160 170 180 190 200
SANNDAEIGN LIAEAMEKVG KNGSITVEEA KGFETVLDIV EGMNFNRGYL
210 220 230 240 250
SSYFATNPET QECVLEDALV LIYDKKISGI KDFLPVLQQV AESGRPLLII
260 270 280 290 300
AEDIEGEALA TLVVNRIRGG FRVCAVKAPG FGDRRKAMLE DIAILTGGQL
310 320 330 340 350
ISEELGMKLE NANLAMLGKA KKVIVSKEDT TIVEGMGEKE ALEARCESIK
360 370 380 390 400
KQIEDSSSDY DKEKLQERLA KLSGGVAVIR VGAATEIEMK EKKDRVDDAQ
410 420 430 440 450
HATIAAVEEG ILPGGGTALI RCIPTLEAFL PMLTNEDEQI GARIVLKALS
460 470 480 490 500
APLKQIAANA GKEGAIIFQQ VMSRSANEGY DALRDAYTDM LEAGILDPAK
510 520 530 540
VTRSALESAA SVAGLLLTTE ALIAEIPEEK PAAAPAMPGA GMDY
Length:544
Mass (Da):58,147
Last modified:January 23, 2007 - v2
Checksum:i2CE404C5BBE6E623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4K → D AA sequence (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti124V → A in strain: L2. 1
Natural varianti131I → V in strain: L2. 1
Natural varianti132R → K in strain: L2. 1
Natural varianti189I → V in strain: L2. 1
Natural varianti191E → D in strain: L2. 1
Natural varianti217D → E in strain: L2. 1
Natural varianti255E → V in strain: L2. 1
Natural varianti264V → G in strain: L2. 1
Natural varianti289L → F in strain: L2. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58027 Genomic DNA. Translation: AAA23128.1.
AE001273 Genomic DNA. Translation: AAC67701.1.
PIRiA71555.
B41479.
RefSeqiNP_219613.1. NC_000117.1.
WP_010725062.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67701; AAC67701; CT_110.
GeneIDi884030.
KEGGictr:CT_110.
PATRICifig|272561.5.peg.120.

Similar proteinsi

Entry informationi

Entry nameiCH60_CHLTR
AccessioniPrimary (citable) accession number: P0C0Z7
Secondary accession number(s): O84112, P17203
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families