Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C0Z2

- UVRA_BRUAB

UniProt

P0C0Z2 - UVRA_BRUAB

Protein

UvrABC system protein A

Gene

uvrA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPUniRule annotation
    Nucleotide bindingi663 – 6708ATPUniRule annotation
    Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. DNA binding Source: UniProtKB-HAMAP
    4. excinuclease ABC activity Source: UniProtKB-HAMAP
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1132-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein AUniRule annotation
    Short name:
    UvrA proteinUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit AUniRule annotation
    Gene namesi
    Name:uvrAUniRule annotation
    Ordered Locus Names:BruAb1_1110
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974UvrABC system protein APRO_0000093038Add
    BLAST

    Proteomic databases

    PRIDEiP0C0Z2.

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1110.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0Z2.
    SMRiP0C0Z2. Positions 7-968.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini331 – 610280ABC transporter 1UniRule annotationAdd
    BLAST
    Domaini630 – 959330ABC transporter 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
    Contains 2 ABC transporter domains.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0178.
    HOGENOMiHOG000050448.
    KOiK03701.
    OMAiNGARQTP.
    OrthoDBiEOG6QK4PS.

    Family and domain databases

    Gene3Di3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPiMF_00205. UvrA.
    InterProiIPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00630. uvra. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C0Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA    50
    EGQRRYVESL SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST 100
    VGTVTEIYDY MRLLFARVGI PYSPATGLPI ESQTVSQMVD RVIALEEGTR 150
    LYILAPIVRG RKGEYRKELA ELQKKGFQRV KVDGTFYEIA DVPPLDKKYK 200
    HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA DKPLPVGETA 250
    EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT 300
    CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY 350
    GFKVSARWSE LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP 400
    NLERRWKETD SAWSREEIER FMASTPCPAC NGYRLKPEAL SVKIGKKHIG 450
    EITEMSIRKA DAWFRDIDGS FNEKQREIAA RILKAIRERL QFLNNVGLDY 500
    LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI GLHQRDNARL 550
    LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP 600
    QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS 650
    ADIPLGTFTA VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG 700
    LEFLDKVIDI DQSPIGRTPR SNPATYTGAF TPIRDWFAGL PEAKARGYQP 750
    GRFSFNVKGG RCEACQGDGV IKIEMHFLPD VYVTCDVCHG KRYNRETLDV 800
    LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL GYIKVGQQAT 850
    TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL 900
    VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK 950
    RSYTGQFLKE LLERRPKRSS QAAE 974
    Length:974
    Mass (Da):107,423
    Last modified:February 7, 2006 - v1
    Checksum:i15F7C2BADB7B3127
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74451.1.
    RefSeqiYP_221812.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74451; AAX74451; BruAb1_1110.
    GeneIDi3339763.
    KEGGibmb:BruAb1_1110.
    PATRICi17823911. VBIBruAbo15061_1178.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74451.1 .
    RefSeqi YP_221812.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali P0C0Z2.
    SMRi P0C0Z2. Positions 7-968.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1110.

    Proteomic databases

    PRIDEi P0C0Z2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74451 ; AAX74451 ; BruAb1_1110 .
    GeneIDi 3339763.
    KEGGi bmb:BruAb1_1110.
    PATRICi 17823911. VBIBruAbo15061_1178.

    Phylogenomic databases

    eggNOGi COG0178.
    HOGENOMi HOG000050448.
    KOi K03701.
    OMAi NGARQTP.
    OrthoDBi EOG6QK4PS.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-1132-MONOMER.

    Miscellaneous databases

    PROi P0C0Z2.

    Family and domain databases

    Gene3Di 3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPi MF_00205. UvrA.
    InterProi IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00630. uvra. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiUVRA_BRUAB
    AccessioniPrimary (citable) accession number: P0C0Z2
    Secondary accession number(s): Q07433, Q57D33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3