UvrABC system protein A - Brucella abortus biovar 1 (strain 9-941)

Preferred order of sections

Names and origin

Protein names

Recommended name:
UvrABC system protein A
Short name=UvrA protein

Alternative name(s):
Excinuclease ABC subunit A

Gene names

Name:	uvrA
Ordered Locus Names:	BruAb1_1110

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length	974 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205
Subunit structure	Forms a heterotetramer with UvrB during the search for lesions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. UvrA family. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Domain	Repeat Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC SOS response Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: HAMAP
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: HAMAP cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP ATPase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 974

974

UvrABC system protein A HAMAP-Rule MF_00205

PRO_0000093038

Regions

Domain

341 – 616

276

ABC transporter 1

Domain

625 – 959

335

ABC transporter 2

Nucleotide binding

34 – 41

8

ATP Potential

Nucleotide binding

663 – 670

8

ATP Potential

Zinc finger

762 – 788

27

C4-type HAMAP-Rule MF_00205

Sequences

Sequence

Length

Mass (Da)

Tools

P0C0Z2 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 15F7C2BADB7B3127
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FASTA

974

107,423

        10         20         30         40         50         60 
MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL 

        70         80         90        100        110        120 
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY MRLLFARVGI 

       130        140        150        160        170        180 
PYSPATGLPI ESQTVSQMVD RVIALEEGTR LYILAPIVRG RKGEYRKELA ELQKKGFQRV 

       190        200        210        220        230        240 
KVDGTFYEIA DVPPLDKKYK HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA 

       250        260        270        280        290        300 
DKPLPVGETA EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT 

       310        320        330        340        350        360 
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY GFKVSARWSE 

       370        380        390        400        410        420 
LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP NLERRWKETD SAWSREEIER 

       430        440        450        460        470        480 
FMASTPCPAC NGYRLKPEAL SVKIGKKHIG EITEMSIRKA DAWFRDIDGS FNEKQREIAA 

       490        500        510        520        530        540 
RILKAIRERL QFLNNVGLDY LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI 

       550        560        570        580        590        600 
GLHQRDNARL LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP 

       610        620        630        640        650        660 
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS ADIPLGTFTA 

       670        680        690        700        710        720 
VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG LEFLDKVIDI DQSPIGRTPR 

       730        740        750        760        770        780 
SNPATYTGAF TPIRDWFAGL PEAKARGYQP GRFSFNVKGG RCEACQGDGV IKIEMHFLPD 

       790        800        810        820        830        840 
VYVTCDVCHG KRYNRETLDV LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL 

       850        860        870        880        890        900 
GYIKVGQQAT TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL 

       910        920        930        940        950        960 
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK RSYTGQFLKE 

       970 
LLERRPKRSS QAAE

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References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX74451.1.
RefSeq	YP_221812.1. NC_006932.1.
3D structure databases
ProteinModelPortal	P0C0Z2.
SMR	P0C0Z2. Positions 7-968.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_1110.
Proteomic databases
PRIDE	P0C0Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX74451; AAX74451; BruAb1_1110.
GeneID	3339763.
KEGG	bmb:BruAb1_1110.
PATRIC	17823911. VBIBruAbo15061_1178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0178.
HOGENOM	HOG000050448.
KO	K03701.
OMA	GAIKGWD.
ProtClustDB	PRK00349.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-1132-MONOMER.
Family and domain databases
Gene3D	3.30.1490.20. 2 hits.
HAMAP	MF_00205. UvrA.
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013815. ATP_grasp_subdomain_1. IPR004602. UvrA. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
TIGRFAMs	TIGR00630. uvra. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRA_BRUAB

Accession

Primary (citable) accession number: P0C0Z2
Secondary accession number(s): Q07433, Q57D33

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents