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P0C0Z2

- UVRA_BRUAB

UniProt

P0C0Z2 - UVRA_BRUAB

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Protein
UvrABC system protein A
Gene
uvrA, BruAb1_1110
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATP Reviewed prediction
Nucleotide bindingi663 – 6708ATP Reviewed prediction
Zinc fingeri762 – 78827C4-typeUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATPase activity Source: InterPro
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBABO262698:GJC2-1132-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein A
Short name:
UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene namesi
Name:uvrA
Ordered Locus Names:BruAb1_1110
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974UvrABC system protein AUniRule annotation
PRO_0000093038Add
BLAST

Proteomic databases

PRIDEiP0C0Z2.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Protein-protein interaction databases

STRINGi262698.BruAb1_1110.

Structurei

3D structure databases

ProteinModelPortaliP0C0Z2.
SMRiP0C0Z2. Positions 7-968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini331 – 610280ABC transporter 1
Add
BLAST
Domaini630 – 959330ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
HOGENOMiHOG000050448.
KOiK03701.
OMAiNGARQTP.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0Z2-1 [UniParc]FASTAAdd to Basket

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MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA    50
EGQRRYVESL SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST 100
VGTVTEIYDY MRLLFARVGI PYSPATGLPI ESQTVSQMVD RVIALEEGTR 150
LYILAPIVRG RKGEYRKELA ELQKKGFQRV KVDGTFYEIA DVPPLDKKYK 200
HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA DKPLPVGETA 250
EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT 300
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY 350
GFKVSARWSE LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP 400
NLERRWKETD SAWSREEIER FMASTPCPAC NGYRLKPEAL SVKIGKKHIG 450
EITEMSIRKA DAWFRDIDGS FNEKQREIAA RILKAIRERL QFLNNVGLDY 500
LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI GLHQRDNARL 550
LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP 600
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS 650
ADIPLGTFTA VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG 700
LEFLDKVIDI DQSPIGRTPR SNPATYTGAF TPIRDWFAGL PEAKARGYQP 750
GRFSFNVKGG RCEACQGDGV IKIEMHFLPD VYVTCDVCHG KRYNRETLDV 800
LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL GYIKVGQQAT 850
TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL 900
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK 950
RSYTGQFLKE LLERRPKRSS QAAE 974
Length:974
Mass (Da):107,423
Last modified:February 7, 2006 - v1
Checksum:i15F7C2BADB7B3127
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74451.1.
RefSeqiYP_221812.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74451; AAX74451; BruAb1_1110.
GeneIDi3339763.
KEGGibmb:BruAb1_1110.
PATRICi17823911. VBIBruAbo15061_1178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74451.1 .
RefSeqi YP_221812.1. NC_006932.1.

3D structure databases

ProteinModelPortali P0C0Z2.
SMRi P0C0Z2. Positions 7-968.
ModBasei Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_1110.

Proteomic databases

PRIDEi P0C0Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74451 ; AAX74451 ; BruAb1_1110 .
GeneIDi 3339763.
KEGGi bmb:BruAb1_1110.
PATRICi 17823911. VBIBruAbo15061_1178.

Phylogenomic databases

eggNOGi COG0178.
HOGENOMi HOG000050448.
KOi K03701.
OMAi NGARQTP.
OrthoDBi EOG6QK4PS.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-1132-MONOMER.

Miscellaneous databases

PROi P0C0Z2.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiUVRA_BRUAB
AccessioniPrimary (citable) accession number: P0C0Z2
Secondary accession number(s): Q07433, Q57D33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi