ID   MTDH_DAVTA              Reviewed;         267 AA.
AC   P0C0Y5; Q2TV79;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   14-DEC-2011, entry version 32.
DE   RecName: Full=Probable NADP-dependent mannitol dehydrogenase;
DE            Short=MtDH;
DE            EC=1.1.1.138;
DE   AltName: Full=Mannitol 2-dehydrogenase [NADP+];
DE   AltName: Allergen=Cla h 8;
OS   Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Dothideomycetidae; Capnodiales; Davidiellaceae;
OC   Davidiella.
OX   NCBI_TaxID=29918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=280202-Berlin;
RA   Denk U., Schneider P., Breitenbach M., Richter K., Radauer C.,
RA   Teige M., Simon-Nobbe B.;
RT   "Cladosporium herbarum NADP-dependent mannitol dehydrogenase, a major
RT   allergen.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-mannitol + NADP(+) = D-fructose + NADPH.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; AY191816; AAO91801.1; -; mRNA.
DR   PDB; 3GDF; X-ray; 2.50 A; A/B/C/D=1-267.
DR   PDB; 3GDG; X-ray; 2.30 A; A/B/C/D=1-267.
DR   PDBsum; 3GDF; -.
DR   PDBsum; 3GDG; -.
DR   ProteinModelPortal; P0C0Y5; -.
DR   Allergome; 2485; Cla h 8.
DR   Allergome; 3207; Cla h 8.0101.
DR   BRENDA; 1.1.1.138; 7286.
DR   GO; GO:0050085; F:mannitol 2-dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; NADP; Oxidoreductase.
FT   CHAIN         1    267       Probable NADP-dependent mannitol
FT                                dehydrogenase.
FT                                /FTId=PRO_0000054728.
FT   NP_BIND      30     55       NADP (By similarity).
FT   NP_BIND     161    180       NADP (By similarity).
FT   ACT_SITE    175    175       Proton acceptor (By similarity).
FT   BINDING     160    160       Substrate (By similarity).
FT   HELIX        12     16
FT   STRAND       22     25
FT   TURN         37     39
FT   STRAND       48     51
FT   STRAND       53     56
FT   HELIX        61     70
FT   HELIX        85     98
FT   STRAND      103    107
FT   HELIX       122    132
FT   HELIX       137    142
FT   HELIX       146    149
FT   STRAND      155    158
FT   STRAND      168    170
FT   HELIX       173    179
FT   HELIX       183    192
FT   TURN        193    196
FT   STRAND      199    203
FT   HELIX       212    214
FT   HELIX       217    224
FT   HELIX       235    237
FT   HELIX       242    246
FT   STRAND      257    259
SQ   SEQUENCE   267 AA;  28464 MW;  4CF5EA012D71D446 CRC64;
     MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA ITYASRAQGA
     EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG QIDAFIANAG ATADSGILDG
     SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER GTGSLVITAS MSGHIANFPQ EQTSYNVAKA
     GCIHMARSLA NEWRDFARVN SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG
     AYVYFASDAS TYTTGADLLI DGGYTTR
//