Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable NADP-dependent mannitol dehydrogenase

Gene
N/A
Organism
Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannitol + NADP+ = D-fructose + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei160SubstrateBy similarity1
Active sitei175Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 55NADPBy similarityAdd BLAST26
Nucleotide bindingi161 – 180NADPBy similarityAdd BLAST20

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.138. 7286.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)
Short name:
MtDH
Alternative name(s):
Mannitol 2-dehydrogenase [NADP(+)]
Allergen: Cla h 8
OrganismiDavidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Taxonomic identifieri29918 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesCladosporiaceaeCladosporium

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2485. Cla h 8.
3207. Cla h 8.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547281 – 267Probable NADP-dependent mannitol dehydrogenaseAdd BLAST267

Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 16Combined sources5
Beta strandi22 – 25Combined sources4
Beta strandi30 – 33Combined sources4
Helixi34 – 44Combined sources11
Beta strandi48 – 51Combined sources4
Beta strandi53 – 58Combined sources6
Helixi59 – 71Combined sources13
Beta strandi75 – 79Combined sources5
Helixi85 – 98Combined sources14
Beta strandi103 – 107Combined sources5
Turni117 – 119Combined sources3
Helixi122 – 132Combined sources11
Helixi134 – 150Combined sources17
Beta strandi154 – 158Combined sources5
Helixi161 – 163Combined sources3
Beta strandi168 – 170Combined sources3
Helixi173 – 192Combined sources20
Turni193 – 196Combined sources4
Beta strandi198 – 204Combined sources7
Beta strandi206 – 210Combined sources5
Helixi212 – 214Combined sources3
Helixi217 – 224Combined sources8
Helixi236 – 246Combined sources11
Helixi248 – 250Combined sources3
Beta strandi257 – 261Combined sources5
Helixi264 – 266Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GDFX-ray2.50A/B/C/D1-267[»]
3GDGX-ray2.30A/B/C/D1-267[»]
ProteinModelPortaliP0C0Y5.
SMRiP0C0Y5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0Y5.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA
60 70 80 90 100
ITYASRAQGA EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG
110 120 130 140 150
QIDAFIANAG ATADSGILDG SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER
160 170 180 190 200
GTGSLVITAS MSGHIANFPQ EQTSYNVAKA GCIHMARSLA NEWRDFARVN
210 220 230 240 250
SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG AYVYFASDAS
260
TYTTGADLLI DGGYTTR
Length:267
Mass (Da):28,464
Last modified:January 24, 2006 - v1
Checksum:i4CF5EA012D71D446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191816 mRNA. Translation: AAO91801.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191816 mRNA. Translation: AAO91801.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GDFX-ray2.50A/B/C/D1-267[»]
3GDGX-ray2.30A/B/C/D1-267[»]
ProteinModelPortaliP0C0Y5.
SMRiP0C0Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2485. Cla h 8.
3207. Cla h 8.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.138. 7286.

Miscellaneous databases

EvolutionaryTraceiP0C0Y5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTDH_DAVTA
AccessioniPrimary (citable) accession number: P0C0Y5
Secondary accession number(s): Q2TV79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.