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Reviewed, UniProtKB/Swiss-Prot P0C0Y5 (MTDH_CLAHE)

Last modified June 16, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable NADP-dependent mannitol dehydrogenase
      Short name=MtDH
    EC=1.1.1.138
Alternative name(s):
    Mannitol 2-dehydrogenase [NADP+]
    Allergen=Cla h 8
OrganismCladosporium herbarum (Davidiella tassiana)
Taxonomic identifier29918 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesDavidiellaceaeDavidiella

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

D-mannitol + NADP+ = D-fructose + NADPH.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   DiseaseAllergen
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Probable NADP-dependent mannitol dehydrogenase
PRO_0000054728

Regions

Nucleotide binding30 – 5526NADP By similarity
Nucleotide binding161 – 18020NADP By similarity

Sites

Active site1751Proton acceptor By similarity
Binding site1601Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C0Y5-1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 4CF5EA012D71D446

FASTA26728,464
        10         20         30         40         50         60 
MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA ITYASRAQGA 

        70         80         90        100        110        120 
EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG QIDAFIANAG ATADSGILDG 

       130        140        150        160        170        180 
SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER GTGSLVITAS MSGHIANFPQ EQTSYNVAKA 

       190        200        210        220        230        240 
GCIHMARSLA NEWRDFARVN SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG 

       250        260 
AYVYFASDAS TYTTGADLLI DGGYTTR 

« Hide

References

[1]"Cladosporium herbarum NADP-dependent mannitol dehydrogenase, a major allergen."
Denk U., Schneider P., Breitenbach M., Richter K., Radauer C., Teige M., Simon-Nobbe B.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 280202-Berlin.

Cross-references

Sequence databases

AY191816 mRNA. Translation: AAO91801.1.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.138. 279238.
1.1.2.2. 279238.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PROSITEPS00061. ADH_SHORT. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTDH_CLAHE
AccessionPrimary (citable) accession number: P0C0Y5
Secondary accession number(s): Q2TV79
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Allergens

Nomenclature of allergens and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents