Reviewed, UniProtKB/Swiss-Prot P0C0Y5 (MTDH_CLAHE)

Names and origin

Protein names	Recommended name:     Probable NADP-dependent mannitol dehydrogenase       Short name=MtDH     EC=1.1.1.138 Alternative name(s):     Mannitol 2-dehydrogenase [NADP+]     Allergen=Cla h 8
Organism	Cladosporium herbarum (Davidiella tassiana)
Taxonomic identifier	29918 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Dothideomycetidae › Capnodiales › Davidiellaceae › Davidiella

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-mannitol + NADP+ = D-fructose + NADPH.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Disease	Allergen
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro mannitol 2-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable NADP-dependent mannitol dehydrogenase		PRO_0000054728
Regions
	Nucleotide binding	30 – 55	26	NADP By similarity
	Nucleotide binding	161 – 180	20	NADP By similarity
Sites
	Active site	175	1	Proton acceptor By similarity
	Binding site	160	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C0Y5-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 4CF5EA012D71D446	FASTA	267	28,464
	10 20 30 40 50 60 MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA ITYASRAQGA 70 80 90 100 110 120 EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG QIDAFIANAG ATADSGILDG 130 140 150 160 170 180 SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER GTGSLVITAS MSGHIANFPQ EQTSYNVAKA 190 200 210 220 230 240 GCIHMARSLA NEWRDFARVN SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG 250 260 AYVYFASDAS TYTTGADLLI DGGYTTR

References

[1]	"Cladosporium herbarum NADP-dependent mannitol dehydrogenase, a major allergen." Denk U., Schneider P., Breitenbach M., Richter K., Radauer C., Teige M., Simon-Nobbe B. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 280202-Berlin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY191816 mRNA. Translation: AAO91801.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.138. 279238. 1.1.2.2. 279238.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTDH_CLAHE

Accession

Primary (citable) accession number: P0C0Y5
Secondary accession number(s): Q2TV79

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)