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Protein

Probable NADP-dependent mannitol dehydrogenase

Gene
N/A
Organism
Davidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannitol + NADP+ = D-fructose + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei160 – 1601SubstrateBy similarity
Active sitei175 – 1751Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 5526NADPBy similarityAdd
BLAST
Nucleotide bindingi161 – 18020NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.1.1.138. 7286.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)
Short name:
MtDH
Alternative name(s):
Mannitol 2-dehydrogenase [NADP(+)]
Allergen: Cla h 8
OrganismiDavidiella tassiana (Mycosphaerella tassiana) (Cladosporium herbarum)
Taxonomic identifieri29918 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesDothideomycetidaeCapnodialesCladosporiaceaeCladosporium

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2485. Cla h 8.
3207. Cla h 8.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Probable NADP-dependent mannitol dehydrogenasePRO_0000054728Add
BLAST

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 165Combined sources
Beta strandi22 – 254Combined sources
Beta strandi30 – 334Combined sources
Helixi34 – 4411Combined sources
Beta strandi48 – 514Combined sources
Beta strandi53 – 586Combined sources
Helixi59 – 7113Combined sources
Beta strandi75 – 795Combined sources
Helixi85 – 9814Combined sources
Beta strandi103 – 1075Combined sources
Turni117 – 1193Combined sources
Helixi122 – 13211Combined sources
Helixi134 – 15017Combined sources
Beta strandi154 – 1585Combined sources
Helixi161 – 1633Combined sources
Beta strandi168 – 1703Combined sources
Helixi173 – 19220Combined sources
Turni193 – 1964Combined sources
Beta strandi198 – 2047Combined sources
Beta strandi206 – 2105Combined sources
Helixi212 – 2143Combined sources
Helixi217 – 2248Combined sources
Helixi236 – 24611Combined sources
Helixi248 – 2503Combined sources
Beta strandi257 – 2615Combined sources
Helixi264 – 2663Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GDFX-ray2.50A/B/C/D1-267[»]
3GDGX-ray2.30A/B/C/D1-267[»]
ProteinModelPortaliP0C0Y5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0Y5.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA
60 70 80 90 100
ITYASRAQGA EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG
110 120 130 140 150
QIDAFIANAG ATADSGILDG SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER
160 170 180 190 200
GTGSLVITAS MSGHIANFPQ EQTSYNVAKA GCIHMARSLA NEWRDFARVN
210 220 230 240 250
SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG AYVYFASDAS
260
TYTTGADLLI DGGYTTR
Length:267
Mass (Da):28,464
Last modified:January 24, 2006 - v1
Checksum:i4CF5EA012D71D446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191816 mRNA. Translation: AAO91801.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191816 mRNA. Translation: AAO91801.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GDFX-ray2.50A/B/C/D1-267[»]
3GDGX-ray2.30A/B/C/D1-267[»]
ProteinModelPortaliP0C0Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2485. Cla h 8.
3207. Cla h 8.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.1.1.138. 7286.

Miscellaneous databases

EvolutionaryTraceiP0C0Y5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 3 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTDH_DAVTA
AccessioniPrimary (citable) accession number: P0C0Y5
Secondary accession number(s): Q2TV79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.