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Protein

Probable NADP-dependent mannitol dehydrogenase

Gene
N/A
Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannitol + NADP+ = D-fructose + NADPH.1 Publication

Kineticsi

  1. KM=474 mM for D-fructose1 Publication
  2. KM=18.7 µM for NADPH1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei159SubstrateBy similarity1
    Active sitei174Proton acceptorBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi29 – 54NADPBy similarityAdd BLAST26
    Nucleotide bindingi160 – 179NADPBy similarityAdd BLAST20

    GO - Molecular functioni

    Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BRENDAi1.1.1.138 267

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)
    Short name:
    MtDH
    Alternative name(s):
    Mannitol 2-dehydrogenase [NADP(+)]
    Allergen: Alt a 8
    OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
    Taxonomic identifieri5599 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei22 Alt a 8
    3065 Alt a 8.0101

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000547271 – 266Probable NADP-dependent mannitol dehydrogenaseAdd BLAST266

    Proteomic databases

    PRIDEiP0C0Y4

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0Y4
    SMRiP0C0Y4
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK17742

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR002347 SDR_fam
    PRINTSiPR00081 GDHRDH
    PR00080 SDRFAMILY
    SUPFAMiSSF51735 SSF51735, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P0C0Y4-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MPISVPQATE LKDLFSLKGK VVIVTGASGP TGIGTEAARG CAEYGADLAI
    60 70 80 90 100
    TYNSRAEGAE KNAKEMSEKY GVKVKAYKCQ VNEYAQCEKL VQDVIKDFGK
    110 120 130 140 150
    VDVFIANAGK TADNGILDAT VEQWNEVIQT DLTGTFNCAR AVGLHFRERK
    160 170 180 190 200
    TGSLVITSSM SGHIANFPQE QASYNVAKAG CIHLAKSLAN EWRDFARVNS
    210 220 230 240 250
    ISPGYIDTGL SDFVPQDIQK LWHSMIPMGR DAKATELKGA YVYFASDASS
    260
    YCTGSDLLID GGYCVR
    Length:266
    Mass (Da):28,735
    Last modified:October 31, 2006 - v2
    Checksum:i96CC180295A38901
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti4S → T in AAO91800 (PubMed:17177674).Curated1

    Mass spectrometryi

    Molecular mass is 28618 Da from positions 1 - 266. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY191815 mRNA Translation: AAO91800.1
    AF541874 Genomic DNA Translation: AAN28666.1
    RefSeqiXP_018388094.1, XM_018534204.1

    Genome annotation databases

    GeneIDi29119798
    KEGGiaalt:CC77DRAFT_931278

    Similar proteinsi

    Entry informationi

    Entry nameiMTDH_ALTAL
    AccessioniPrimary (citable) accession number: P0C0Y4
    Secondary accession number(s): Q2TV80, Q8J231
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: October 31, 2006
    Last modified: May 23, 2018
    This is version 50 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

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