P0C0X3 (TFB5_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA polymerase II transcription factor B subunit 5

Alternative name(s):
General transcription and DNA repair factor IIH subunit 5
Short name=TFIIH subunit 5

Gene names

Name:	TFB5
ORF Names:	CaO19.11919.1, CaO19.4439.1

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	69 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the general transcription and DNA repair factor IIH (TFIIH), which is essential for both basal and activated transcription, as well as for nucleotide excision repair (NER) of DNA. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits By similarity.
Subunit structure	Component of the core TFIIH complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the TFB5 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide-excision repair Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	core TFIIH complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 69	69	RNA polymerase II transcription factor B subunit 5		PRO_0000119278

Sequences

	Sequence		Length	Mass (Da)
	P0C0X3 [UniParc]. Last modified January 10, 2006. Version 1. Checksum: FB2E15632254DA25	FASTA	69	7,767
	10 20 30 40 50 60 MLVASKGVLV QCDPSIKALI IQIDSSSSGI ILEELDETHL LIQHDKVNFV KSELNRLLSK NIYNPFEEE

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000111 Genomic DNA. No translation available. AACQ01000115 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P0C0X3.
SMR	P0C0X3. Positions 4-65.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAF0007011.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
CGD	CAF0007011. orf19.4439.1.
Phylogenomic databases
eggNOG	NOG148452.
Family and domain databases
Gene3D	3.30.70.1220. 1 hit.
InterPro	IPR009400. TFIIH_TTDA/Tfb5. [Graphical view]
Pfam	PF06331. Tbf5. 1 hit. [Graphical view]
SUPFAM	SSF142897. SSF142897. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TFB5_CANAL

Accession

Primary (citable) accession number: P0C0X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program