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Protein

Inactive dihydropteroate synthase 2

Gene

folP2

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193Characteristic for family members without dihydropteroate synthase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1157-MONOMER
BRENDAi2.5.1.15 3504

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dihydropteroate synthase 2
Short name:
DHPS 2
Alternative name(s):
Dihydropteroate pyrophosphorylase 2
Gene namesi
Name:folP2
Ordered Locus Names:ML1063
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1063

Pathology & Biotechi

Chemistry databases

DrugBankiDB00250 Dapsone

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682141 – 291Inactive dihydropteroate synthase 2Add BLAST291

Proteomic databases

PRIDEiP0C0X2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1063

Structurei

3D structure databases

ProteinModelPortaliP0C0X2
SMRiP0C0X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 272Pterin-bindingPROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the DHPS family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217509
KOiK00796
OMAiDPGHDFG
OrthoDBiPOG091H00BJ

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSMLCGRPV AADRQLIMAI VNRTPDSFYD RGATFSDEAA RAAAHRAVAE
60 70 80 90 100
GADVIDVGGV KAGPGQGVDV DTEIARLVPF IEWLRSAYTD LLISVDTWRA
110 120 130 140 150
EVARLACTAG ADLINDSWGG ADPAMHEVAA ELGAGLVCSH TGGALPRTRP
160 170 180 190 200
FRVSYGTTTR GVVDDVIRQV TAAAERAVAA GVTRDSVLVD PTHDFGKNTF
210 220 230 240 250
HGLLLLRHVD ELVKTGWPVL MSLSNKDFVG ETLGVGLTER LEGTLAATAL
260 270 280 290
AAAAGVRMFR VHEVVATRRV LEMVASIQGT RPPTRTVRGL A
Length:291
Mass (Da):30,851
Last modified:January 10, 2006 - v1
Checksum:i4243E35BB0E4C60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15180 Genomic DNA Translation: AAA62918.1
AL583920 Genomic DNA Translation: CAC31444.1
PIRiT45179
RefSeqiNP_301781.1, NC_002677.1
WP_010908105.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC31444; CAC31444; CAC31444
GeneIDi910150
KEGGimle:ML1063
PATRICifig|272631.5.peg.1909

Similar proteinsi

Entry informationi

Entry nameiDHPS2_MYCLE
AccessioniPrimary (citable) accession number: P0C0X2
Secondary accession number(s): P46812
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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