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Protein

Inactive dihydropteroate synthase 2

Gene

folP2

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has very low affinity for the DHPS substrate 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei193Characteristic for family members without dihydropteroate synthase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi2.5.1.15. 3504.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dihydropteroate synthase 2
Short name:
DHPS 2
Alternative name(s):
Dihydropteroate pyrophosphorylase 2
Gene namesi
Name:folP2
Ordered Locus Names:ML1063
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1063.

Pathology & Biotechi

Chemistry databases

DrugBankiDB00250. Dapsone.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682141 – 291Inactive dihydropteroate synthase 2Add BLAST291

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML1063.

Structurei

3D structure databases

ProteinModelPortaliP0C0X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 272Pterin-bindingPROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
HOGENOMiHOG000217509.
KOiK00796.
OMAiFYDGGRN.
OrthoDBiPOG091H00BJ.

Family and domain databases

CDDicd00739. DHPS. 1 hit.
Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSMLCGRPV AADRQLIMAI VNRTPDSFYD RGATFSDEAA RAAAHRAVAE
60 70 80 90 100
GADVIDVGGV KAGPGQGVDV DTEIARLVPF IEWLRSAYTD LLISVDTWRA
110 120 130 140 150
EVARLACTAG ADLINDSWGG ADPAMHEVAA ELGAGLVCSH TGGALPRTRP
160 170 180 190 200
FRVSYGTTTR GVVDDVIRQV TAAAERAVAA GVTRDSVLVD PTHDFGKNTF
210 220 230 240 250
HGLLLLRHVD ELVKTGWPVL MSLSNKDFVG ETLGVGLTER LEGTLAATAL
260 270 280 290
AAAAGVRMFR VHEVVATRRV LEMVASIQGT RPPTRTVRGL A
Length:291
Mass (Da):30,851
Last modified:January 10, 2006 - v1
Checksum:i4243E35BB0E4C60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15180 Genomic DNA. Translation: AAA62918.1.
AL583920 Genomic DNA. Translation: CAC31444.1.
PIRiT45179.
RefSeqiNP_301781.1. NC_002677.1.
WP_010908105.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31444; CAC31444; CAC31444.
GeneIDi910150.
KEGGimle:ML1063.
PATRICi18053928. VBIMycLep78757_1909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15180 Genomic DNA. Translation: AAA62918.1.
AL583920 Genomic DNA. Translation: CAC31444.1.
PIRiT45179.
RefSeqiNP_301781.1. NC_002677.1.
WP_010908105.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP0C0X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1063.

Chemistry databases

DrugBankiDB00250. Dapsone.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31444; CAC31444; CAC31444.
GeneIDi910150.
KEGGimle:ML1063.
PATRICi18053928. VBIMycLep78757_1909.

Organism-specific databases

LepromaiML1063.

Phylogenomic databases

eggNOGiENOG4105EEI. Bacteria.
COG0294. LUCA.
HOGENOMiHOG000217509.
KOiK00796.
OMAiFYDGGRN.
OrthoDBiPOG091H00BJ.

Enzyme and pathway databases

BRENDAi2.5.1.15. 3504.

Family and domain databases

CDDicd00739. DHPS. 1 hit.
Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding_dom.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHPS2_MYCLE
AccessioniPrimary (citable) accession number: P0C0X2
Secondary accession number(s): P46812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.