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P0C0X1

- DHPS1_MYCLE

UniProt

P0C0X1 - DHPS1_MYCLE

Protein

Dihydropteroate synthase 1

Gene

folP1

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.By similarity

    Catalytic activityi

    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Cofactori

    Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131MagnesiumBy similarity
    Binding sitei21 – 211SubstrateBy similarity
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei105 – 1051SubstrateBy similarity
    Binding sitei177 – 1771SubstrateBy similarity
    Binding sitei213 – 2131SubstrateBy similarity
    Binding sitei253 – 2531SubstrateBy similarity
    Binding sitei255 – 2551SubstrateBy similarity

    GO - Molecular functioni

    1. dihydropteroate synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. response to antibiotic Source: UniProtKB-KW
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Antibiotic resistance, Folate biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydropteroate synthase 1 (EC:2.5.1.15)
    Short name:
    DHPS 1
    Alternative name(s):
    Dihydropteroate pyrophosphorylase 1
    Gene namesi
    Name:folP1
    Synonyms:folP
    Ordered Locus Names:ML0224
    ORF Names:MLCB2548.07c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0224.

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Dihydropteroate synthase 1PRO_0000168213Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi272631.ML0224.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0X1.
    SMRiP0C0X1. Positions 5-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 265260Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DHPS family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    HOGENOMiHOG000217509.
    KOiK00796.
    OMAiDCWISVD.
    OrthoDBiEOG67T5P5.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C0X1-1 [UniParc]FASTAAdd to Basket

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    MSLAPVQVIG VLNVTDNSFS DGGRYLDPDD AVQHGLAMVA EGAAIVDVGG    50
    ESTRPGAIRT DPRVELSRIV PVVKELAAQG ITVSIDTTRA DVARAALQSG 100
    ARIVNDVSGG RADPAMAPLV AEAGVAWVLM HWRLMSAERP YEAPNYRDVV 150
    AEVRADLLAG VDQAVAAGVD PGSLVIDPGL GFAKTGQHNW ALLNALPELV 200
    ATGVPILLGA SRKRFLGRLL AGADGAVRPP DGRETATAVI SALAALHGAW 250
    GVRVHDVRAS VDALKVVGAW LHAGPQIEKV RCDG 284
    Length:284
    Mass (Da):29,448
    Last modified:January 10, 2006 - v1
    Checksum:iA576FF46C16AC826
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531T → A in BAA84081. (PubMed:10474189)Curated
    Sequence conflicti53 – 531T → I in BAA84080. (PubMed:10474189)Curated
    Sequence conflicti53 – 531T → I in BAA84079. (PubMed:10474189)Curated
    Sequence conflicti55 – 551P → L in BAA84078. (PubMed:10474189)Curated
    Sequence conflicti55 – 551P → L in BAA84077. (PubMed:10474189)Curated
    Sequence conflicti55 – 551P → L in BAA84076. (PubMed:10474189)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028658 Genomic DNA. Translation: BAA84076.1.
    AB028659 Genomic DNA. Translation: BAA84077.1.
    AB028660 Genomic DNA. Translation: BAA84078.1.
    AB028661 Genomic DNA. Translation: BAA84079.1.
    AB028662 Genomic DNA. Translation: BAA84080.1.
    AB028663 Genomic DNA. Translation: BAA84081.1.
    AB028656 Genomic DNA. Translation: BAA84074.1.
    AB028657 Genomic DNA. Translation: BAA84075.1.
    AF117618 Genomic DNA. Translation: AAF06725.1.
    AL023093 Genomic DNA. Translation: CAA18794.1.
    AL583917 Genomic DNA. Translation: CAC29732.1.
    PIRiH86936.
    RefSeqiNP_301284.1. NC_002677.1.
    WP_010907608.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29732; CAC29732; CAC29732.
    GeneIDi908646.
    KEGGimle:ML0224.
    PATRICi18050810. VBIMycLep78757_0356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028658 Genomic DNA. Translation: BAA84076.1 .
    AB028659 Genomic DNA. Translation: BAA84077.1 .
    AB028660 Genomic DNA. Translation: BAA84078.1 .
    AB028661 Genomic DNA. Translation: BAA84079.1 .
    AB028662 Genomic DNA. Translation: BAA84080.1 .
    AB028663 Genomic DNA. Translation: BAA84081.1 .
    AB028656 Genomic DNA. Translation: BAA84074.1 .
    AB028657 Genomic DNA. Translation: BAA84075.1 .
    AF117618 Genomic DNA. Translation: AAF06725.1 .
    AL023093 Genomic DNA. Translation: CAA18794.1 .
    AL583917 Genomic DNA. Translation: CAC29732.1 .
    PIRi H86936.
    RefSeqi NP_301284.1. NC_002677.1.
    WP_010907608.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P0C0X1.
    SMRi P0C0X1. Positions 5-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0224.

    Chemistry

    ChEMBLi CHEMBL2362993.
    DrugBanki DB00250. Dapsone.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29732 ; CAC29732 ; CAC29732 .
    GeneIDi 908646.
    KEGGi mle:ML0224.
    PATRICi 18050810. VBIMycLep78757_0356.

    Organism-specific databases

    Lepromai ML0224.

    Phylogenomic databases

    eggNOGi COG0294.
    HOGENOMi HOG000217509.
    KOi K00796.
    OMAi DCWISVD.
    OrthoDBi EOG67T5P5.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00156 .

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene."
      Kai M., Matsuoka M., Nakata N., Maeda S., Gidoh M., Maeda Y., Hashimoto K., Kobayashi K., Kashiwabara Y.
      FEMS Microbiol. Lett. 177:231-235(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli."
      Nopponpunth V., Sirawaraporn W., Greene P.J., Santi D.V.
      J. Bacteriol. 181:6814-6821(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiDHPS1_MYCLE
    AccessioniPrimary (citable) accession number: P0C0X1
    Secondary accession number(s): O69530
    , P46812, Q9R2Q6, Q9R2U9, Q9S0T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3