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P0C0X1

- DHPS1_MYCLE

UniProt

P0C0X1 - DHPS1_MYCLE

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Protein

Dihydropteroate synthase 1

Gene

folP1

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity).By similarity

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131MagnesiumBy similarity
Binding sitei21 – 211SubstrateBy similarity
Binding sitei86 – 861SubstrateBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Binding sitei177 – 1771SubstrateBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei253 – 2531SubstrateBy similarity
Binding sitei255 – 2551SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase 1 (EC:2.5.1.15)
Short name:
DHPS 1
Alternative name(s):
Dihydropteroate pyrophosphorylase 1
Gene namesi
Name:folP1
Synonyms:folP
Ordered Locus Names:ML0224
ORF Names:MLCB2548.07c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0224.

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Dihydropteroate synthase 1PRO_0000168213Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272631.ML0224.

Structurei

3D structure databases

ProteinModelPortaliP0C0X1.
SMRiP0C0X1. Positions 5-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 265260Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217509.
KOiK00796.
OMAiDCWISVD.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0X1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLAPVQVIG VLNVTDNSFS DGGRYLDPDD AVQHGLAMVA EGAAIVDVGG
60 70 80 90 100
ESTRPGAIRT DPRVELSRIV PVVKELAAQG ITVSIDTTRA DVARAALQSG
110 120 130 140 150
ARIVNDVSGG RADPAMAPLV AEAGVAWVLM HWRLMSAERP YEAPNYRDVV
160 170 180 190 200
AEVRADLLAG VDQAVAAGVD PGSLVIDPGL GFAKTGQHNW ALLNALPELV
210 220 230 240 250
ATGVPILLGA SRKRFLGRLL AGADGAVRPP DGRETATAVI SALAALHGAW
260 270 280
GVRVHDVRAS VDALKVVGAW LHAGPQIEKV RCDG
Length:284
Mass (Da):29,448
Last modified:January 10, 2006 - v1
Checksum:iA576FF46C16AC826
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531T → A in BAA84081. (PubMed:10474189)Curated
Sequence conflicti53 – 531T → I in BAA84080. (PubMed:10474189)Curated
Sequence conflicti53 – 531T → I in BAA84079. (PubMed:10474189)Curated
Sequence conflicti55 – 551P → L in BAA84078. (PubMed:10474189)Curated
Sequence conflicti55 – 551P → L in BAA84077. (PubMed:10474189)Curated
Sequence conflicti55 – 551P → L in BAA84076. (PubMed:10474189)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028658 Genomic DNA. Translation: BAA84076.1.
AB028659 Genomic DNA. Translation: BAA84077.1.
AB028660 Genomic DNA. Translation: BAA84078.1.
AB028661 Genomic DNA. Translation: BAA84079.1.
AB028662 Genomic DNA. Translation: BAA84080.1.
AB028663 Genomic DNA. Translation: BAA84081.1.
AB028656 Genomic DNA. Translation: BAA84074.1.
AB028657 Genomic DNA. Translation: BAA84075.1.
AF117618 Genomic DNA. Translation: AAF06725.1.
AL023093 Genomic DNA. Translation: CAA18794.1.
AL583917 Genomic DNA. Translation: CAC29732.1.
PIRiH86936.
RefSeqiNP_301284.1. NC_002677.1.
WP_010907608.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29732; CAC29732; CAC29732.
GeneIDi908646.
KEGGimle:ML0224.
PATRICi18050810. VBIMycLep78757_0356.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028658 Genomic DNA. Translation: BAA84076.1 .
AB028659 Genomic DNA. Translation: BAA84077.1 .
AB028660 Genomic DNA. Translation: BAA84078.1 .
AB028661 Genomic DNA. Translation: BAA84079.1 .
AB028662 Genomic DNA. Translation: BAA84080.1 .
AB028663 Genomic DNA. Translation: BAA84081.1 .
AB028656 Genomic DNA. Translation: BAA84074.1 .
AB028657 Genomic DNA. Translation: BAA84075.1 .
AF117618 Genomic DNA. Translation: AAF06725.1 .
AL023093 Genomic DNA. Translation: CAA18794.1 .
AL583917 Genomic DNA. Translation: CAC29732.1 .
PIRi H86936.
RefSeqi NP_301284.1. NC_002677.1.
WP_010907608.1. NC_002677.1.

3D structure databases

ProteinModelPortali P0C0X1.
SMRi P0C0X1. Positions 5-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0224.

Chemistry

ChEMBLi CHEMBL2362993.
DrugBanki DB00250. Dapsone.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29732 ; CAC29732 ; CAC29732 .
GeneIDi 908646.
KEGGi mle:ML0224.
PATRICi 18050810. VBIMycLep78757_0356.

Organism-specific databases

Lepromai ML0224.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217509.
KOi K00796.
OMAi DCWISVD.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene."
    Kai M., Matsuoka M., Nakata N., Maeda S., Gidoh M., Maeda Y., Hashimoto K., Kobayashi K., Kashiwabara Y.
    FEMS Microbiol. Lett. 177:231-235(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli."
    Nopponpunth V., Sirawaraporn W., Greene P.J., Santi D.V.
    J. Bacteriol. 181:6814-6821(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiDHPS1_MYCLE
AccessioniPrimary (citable) accession number: P0C0X1
Secondary accession number(s): O69530
, P46812, Q9R2Q6, Q9R2U9, Q9S0T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3