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P0C0W9

- RL11A_YEAST

UniProt

P0C0W9 - RL11A_YEAST

Protein

60S ribosomal protein L11-A

Gene

RPL11A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Binds to 5S ribosomal RNA.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. ribosomal large subunit assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34242-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L11-A
    Alternative name(s):
    L16
    RP39
    YL22
    Gene namesi
    Name:RPL11A
    Synonyms:RP39A, RPL16A
    Ordered Locus Names:YPR102C
    ORF Names:P8283.14
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    SGDiS000006306. RPL11A.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: The SYO1/RPL11/RPL5 complex is transported into the nucleus by KAP104.

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 17417360S ribosomal protein L11-APRO_0000125104Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP0C0W9.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C0W9.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Forms a heterotrimeric complex with RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi36268. 45 interactions.
    DIPiDIP-4764N.
    IntActiP0C0W9. 22 interactions.
    MINTiMINT-8285559.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-J7-171[»]
    1S1Ielectron microscopy11.70J2-174[»]
    1VW8electron microscopy6.10K1-174[»]
    1VWUelectron microscopy6.10K1-174[»]
    3IZSelectron microscopy-E1-174[»]
    3J65electron microscopy8.70E1-174[»]
    3O58X-ray4.00K1-174[»]
    3O5HX-ray4.00K1-174[»]
    3U5EX-ray3.00J1-174[»]
    3U5IX-ray3.00J1-174[»]
    4BYNelectron microscopy4.30J2-174[»]
    4BYUelectron microscopy6.60J2-174[»]
    4CUWelectron microscopy3.70J1-174[»]
    ProteinModelPortaliP0C0W9.
    SMRiP0C0W9. Positions 6-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C0W9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L5P family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000013411.
    HOGENOMiHOG000231312.
    KOiK02868.
    OMAiEDTMAWF.
    OrthoDBiEOG7GBG86.

    Family and domain databases

    Gene3Di3.30.1440.10. 1 hit.
    InterProiIPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view]
    PANTHERiPTHR11994. PTHR11994. 1 hit.
    PfamiPF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMiSSF55282. SSF55282. 1 hit.
    PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C0W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAKAQNPMR DLKIEKLVLN ISVGESGDRL TRASKVLEQL SGQTPVQSKA    50
    RYTVRTFGIR RNEKIAVHVT VRGPKAEEIL ERGLKVKEYQ LRDRNFSATG 100
    NFGFGIDEHI DLGIKYDPSI GIFGMDFYVV MNRPGARVTR RKRCKGTVGN 150
    SHKTTKEDTV SWFKQKYDAD VLDK 174
    Length:174
    Mass (Da):19,720
    Last modified:January 23, 2007 - v2
    Checksum:i1E5C7D83541C6854
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121L → D AA sequence (PubMed:1544921)Curated
    Sequence conflicti25 – 251E → Q in CAA25515. (PubMed:6090215)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01029 Genomic DNA. Translation: CAA25515.1.
    U32445 Genomic DNA. Translation: AAB68072.1.
    AY693151 Genomic DNA. Translation: AAT93170.1.
    BK006949 Genomic DNA. Translation: DAA11516.1.
    PIRiS59767.
    RefSeqiNP_015427.1. NM_001184199.1.

    Genome annotation databases

    EnsemblFungiiYPR102C; YPR102C; YPR102C.
    GeneIDi856217.
    KEGGisce:YPR102C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01029 Genomic DNA. Translation: CAA25515.1 .
    U32445 Genomic DNA. Translation: AAB68072.1 .
    AY693151 Genomic DNA. Translation: AAT93170.1 .
    BK006949 Genomic DNA. Translation: DAA11516.1 .
    PIRi S59767.
    RefSeqi NP_015427.1. NM_001184199.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - J 7-171 [» ]
    1S1I electron microscopy 11.70 J 2-174 [» ]
    1VW8 electron microscopy 6.10 K 1-174 [» ]
    1VWU electron microscopy 6.10 K 1-174 [» ]
    3IZS electron microscopy - E 1-174 [» ]
    3J65 electron microscopy 8.70 E 1-174 [» ]
    3O58 X-ray 4.00 K 1-174 [» ]
    3O5H X-ray 4.00 K 1-174 [» ]
    3U5E X-ray 3.00 J 1-174 [» ]
    3U5I X-ray 3.00 J 1-174 [» ]
    4BYN electron microscopy 4.30 J 2-174 [» ]
    4BYU electron microscopy 6.60 J 2-174 [» ]
    4CUW electron microscopy 3.70 J 1-174 [» ]
    ProteinModelPortali P0C0W9.
    SMRi P0C0W9. Positions 6-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36268. 45 interactions.
    DIPi DIP-4764N.
    IntActi P0C0W9. 22 interactions.
    MINTi MINT-8285559.

    Proteomic databases

    PRIDEi P0C0W9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR102C ; YPR102C ; YPR102C .
    GeneIDi 856217.
    KEGGi sce:YPR102C.

    Organism-specific databases

    SGDi S000006306. RPL11A.

    Phylogenomic databases

    GeneTreei ENSGT00390000013411.
    HOGENOMi HOG000231312.
    KOi K02868.
    OMAi EDTMAWF.
    OrthoDBi EOG7GBG86.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34242-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0C0W9.
    NextBioi 981438.

    Gene expression databases

    Genevestigatori P0C0W9.

    Family and domain databases

    Gene3Di 3.30.1440.10. 1 hit.
    InterProi IPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view ]
    PANTHERi PTHR11994. PTHR11994. 1 hit.
    Pfami PF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMi SSF55282. SSF55282. 1 hit.
    PROSITEi PS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of the gene encoding yeast ribosomal protein L16."
      Leer R.J., van Raamsdonk-Duin M.M.C., Mager W.H., Planta R.J.
      FEBS Lett. 175:371-376(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-17, ACETYLATION AT SER-2 BY NATA.
    6. "Localization of Saccharomyces cerevisiae ribosomal protein L16 on the surface of 60 S ribosomal subunits by immunoelectron microscopy."
      Tsay Y.-F., Shankweiler G., Lake J., Woolford J.L. Jr.
      J. Biol. Chem. 269:7579-7586(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    7. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    8. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: INTERACTION WITH RPL5 AND SYO1, SUBCELLULAR LOCATION.
    13. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 7-171, ELECTRON MICROSCOPY.
    14. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    15. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    16. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL11A_YEAST
    AccessioniPrimary (citable) accession number: P0C0W9
    Secondary accession number(s): D6W4A0, P06380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 39000 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L11 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3