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Protein

60S ribosomal protein L11-A

Gene

RPL11A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to 5S ribosomal RNA.

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34242-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11-A
Alternative name(s):
L16
RP39
YL22
Gene namesi
Name:RPL11A
Synonyms:RP39A, RPL16A
Ordered Locus Names:YPR102C
ORF Names:P8283.14
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR102C.
SGDiS000006306. RPL11A.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: The SYO1/RPL11/RPL5 complex is transported into the nucleus by KAP104.

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001251042 – 17460S ribosomal protein L11-AAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources2 Publications1
Modified residuei75N6,N6,N6-trimethyllysine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.2 Publications

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiP0C0W9.
PRIDEiP0C0W9.

PTM databases

iPTMnetiP0C0W9.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Forms a heterotrimeric complex with RPL5 and SYO1. Interaction of this complex with KAP104 allows the nuclear import of the heterotrimer.1 Publication

Protein-protein interaction databases

BioGridi36268. 45 interactors.
DIPiDIP-4764N.
IntActiP0C0W9. 25 interactors.
MINTiMINT-8285559.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-J7-171[»]
3J6Xelectron microscopy6.10511-174[»]
3J6Yelectron microscopy6.10511-174[»]
3J77electron microscopy6.20611-174[»]
3J78electron microscopy6.30611-174[»]
3JCTelectron microscopy3.08J1-174[»]
4V4Belectron microscopy11.70BJ2-174[»]
4V6Ielectron microscopy8.80BE1-174[»]
4V7Felectron microscopy8.70E1-174[»]
4V7RX-ray4.00BK/DK1-174[»]
4V88X-ray3.00BJ/DJ1-174[»]
4V8Yelectron microscopy4.30BJ2-174[»]
4V8Zelectron microscopy6.60BJ2-174[»]
4V91electron microscopy3.70J1-174[»]
5APNelectron microscopy3.91J1-174[»]
5APOelectron microscopy3.41J1-174[»]
5FCIX-ray3.40M1/m12-174[»]
5FCJX-ray3.10M1/m12-174[»]
5FL8electron microscopy9.50J1-174[»]
5GAKelectron microscopy3.88M1-174[»]
5JUOelectron microscopy4.00O1-174[»]
5JUPelectron microscopy3.50O1-174[»]
5JUSelectron microscopy4.20O1-174[»]
5JUTelectron microscopy4.00O1-174[»]
5JUUelectron microscopy4.00O1-174[»]
ProteinModelPortaliP0C0W9.
SMRiP0C0W9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0W9.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000013411.
HOGENOMiHOG000231312.
InParanoidiP0C0W9.
KOiK02868.
OMAiNPMKELK.
OrthoDBiEOG092C53PI.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKAQNPMR DLKIEKLVLN ISVGESGDRL TRASKVLEQL SGQTPVQSKA
60 70 80 90 100
RYTVRTFGIR RNEKIAVHVT VRGPKAEEIL ERGLKVKEYQ LRDRNFSATG
110 120 130 140 150
NFGFGIDEHI DLGIKYDPSI GIFGMDFYVV MNRPGARVTR RKRCKGTVGN
160 170
SHKTTKEDTV SWFKQKYDAD VLDK
Length:174
Mass (Da):19,720
Last modified:January 23, 2007 - v2
Checksum:i1E5C7D83541C6854
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → D AA sequence (PubMed:1544921).Curated1
Sequence conflicti25E → Q in CAA25515 (PubMed:6090215).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01029 Genomic DNA. Translation: CAA25515.1.
U32445 Genomic DNA. Translation: AAB68072.1.
AY693151 Genomic DNA. Translation: AAT93170.1.
BK006949 Genomic DNA. Translation: DAA11516.1.
PIRiS59767.
RefSeqiNP_015427.1. NM_001184199.1.

Genome annotation databases

EnsemblFungiiYPR102C; YPR102C; YPR102C.
GeneIDi856217.
KEGGisce:YPR102C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01029 Genomic DNA. Translation: CAA25515.1.
U32445 Genomic DNA. Translation: AAB68072.1.
AY693151 Genomic DNA. Translation: AAT93170.1.
BK006949 Genomic DNA. Translation: DAA11516.1.
PIRiS59767.
RefSeqiNP_015427.1. NM_001184199.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-J7-171[»]
3J6Xelectron microscopy6.10511-174[»]
3J6Yelectron microscopy6.10511-174[»]
3J77electron microscopy6.20611-174[»]
3J78electron microscopy6.30611-174[»]
3JCTelectron microscopy3.08J1-174[»]
4V4Belectron microscopy11.70BJ2-174[»]
4V6Ielectron microscopy8.80BE1-174[»]
4V7Felectron microscopy8.70E1-174[»]
4V7RX-ray4.00BK/DK1-174[»]
4V88X-ray3.00BJ/DJ1-174[»]
4V8Yelectron microscopy4.30BJ2-174[»]
4V8Zelectron microscopy6.60BJ2-174[»]
4V91electron microscopy3.70J1-174[»]
5APNelectron microscopy3.91J1-174[»]
5APOelectron microscopy3.41J1-174[»]
5FCIX-ray3.40M1/m12-174[»]
5FCJX-ray3.10M1/m12-174[»]
5FL8electron microscopy9.50J1-174[»]
5GAKelectron microscopy3.88M1-174[»]
5JUOelectron microscopy4.00O1-174[»]
5JUPelectron microscopy3.50O1-174[»]
5JUSelectron microscopy4.20O1-174[»]
5JUTelectron microscopy4.00O1-174[»]
5JUUelectron microscopy4.00O1-174[»]
ProteinModelPortaliP0C0W9.
SMRiP0C0W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36268. 45 interactors.
DIPiDIP-4764N.
IntActiP0C0W9. 25 interactors.
MINTiMINT-8285559.

PTM databases

iPTMnetiP0C0W9.

Proteomic databases

MaxQBiP0C0W9.
PRIDEiP0C0W9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR102C; YPR102C; YPR102C.
GeneIDi856217.
KEGGisce:YPR102C.

Organism-specific databases

EuPathDBiFungiDB:YPR102C.
SGDiS000006306. RPL11A.

Phylogenomic databases

GeneTreeiENSGT00390000013411.
HOGENOMiHOG000231312.
InParanoidiP0C0W9.
KOiK02868.
OMAiNPMKELK.
OrthoDBiEOG092C53PI.

Enzyme and pathway databases

BioCyciYEAST:G3O-34242-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL16A. yeast.
EvolutionaryTraceiP0C0W9.
PROiP0C0W9.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR031309. Ribosomal_L5_C.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
IPR031310. Ribosomal_L5_N.
[Graphical view]
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL11A_YEAST
AccessioniPrimary (citable) accession number: P0C0W9
Secondary accession number(s): D6W4A0, P06380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 39000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L11 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.