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Protein

Probable G-protein coupled receptor 139

Gene

Gpr139

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 139
Alternative name(s):
G(q)-coupled orphan receptor GPRg1
Gene namesi
Name:Gpr139
Synonyms:Gprg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1311729. Gpr139.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 57CytoplasmicSequence analysisAdd BLAST15
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 94ExtracellularSequence analysisAdd BLAST16
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 140CytoplasmicSequence analysisAdd BLAST25
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 173ExtracellularSequence analysisAdd BLAST12
Transmembranei174 – 194Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini195 – 220CytoplasmicSequence analysisAdd BLAST26
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 260ExtracellularSequence analysisAdd BLAST19
Transmembranei261 – 281Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini282 – 345CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696171 – 345Probable G-protein coupled receptor 139Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C0W8.
PRIDEiP0C0W8.

PTM databases

PhosphoSitePlusiP0C0W8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000023863.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037722.

Structurei

3D structure databases

ProteinModelPortaliP0C0W8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiP0C0W8.
KOiK08428.
OMAiNLWTEDY.
OrthoDBiEOG091G0HIF.
PhylomeDBiP0C0W8.
TreeFamiTF334275.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTHAHLAA NSSACGLGFV PVVYYSFLLC LGLPANILTV IILSQLVARR
60 70 80 90 100
QKSSYNYLLA LAAADILVLF FIVFVDFLLE DFILTMQMPP IPDKIIEVLE
110 120 130 140 150
FSSIHTSIWI TVPLTVDRYI AVCHPLKYHT VSYPARTRKV ILSVYITCFL
160 170 180 190 200
TSIPYYWWPN IWTEDYISTS MHHVLVWIHC FTVYLVPCSI FFILNSIIVY
210 220 230 240 250
KLRRKSNFRL RGYSTGKTTA ILFTITSIFA TLWAPRIIMI LYHLYGAPIQ
260 270 280 290 300
NPWLVHIMLD VANMLALLNT AINFFLYCFI SKRFRTMAAA TLKALFKCQK
310 320 330 340
QPVQFYTNHN FSITSSPWIS PANSHCIKML VYQYDKHGKP IKVSP
Length:345
Mass (Da):39,742
Last modified:January 10, 2006 - v1
Checksum:i270D568005EB6031
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196531 mRNA. Translation: BAD97442.1.
RefSeqiNP_001019412.1. NM_001024241.1.
UniGeneiRn.215835.

Genome annotation databases

EnsembliENSRNOT00000032796; ENSRNOP00000037722; ENSRNOG00000023863.
GeneIDi293545.
KEGGirno:293545.
UCSCiRGD:1311729. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196531 mRNA. Translation: BAD97442.1.
RefSeqiNP_001019412.1. NM_001024241.1.
UniGeneiRn.215835.

3D structure databases

ProteinModelPortaliP0C0W8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037722.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP0C0W8.

Proteomic databases

PaxDbiP0C0W8.
PRIDEiP0C0W8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032796; ENSRNOP00000037722; ENSRNOG00000023863.
GeneIDi293545.
KEGGirno:293545.
UCSCiRGD:1311729. rat.

Organism-specific databases

CTDi124274.
RGDi1311729. Gpr139.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiP0C0W8.
KOiK08428.
OMAiNLWTEDY.
OrthoDBiEOG091G0HIF.
PhylomeDBiP0C0W8.
TreeFamiTF334275.

Miscellaneous databases

PROiP0C0W8.

Gene expression databases

BgeeiENSRNOG00000023863.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP139_RAT
AccessioniPrimary (citable) accession number: P0C0W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.