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P0C0W1 (RS22A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S22-A
Alternative name(s):
RP50
S24
YP58
YS22
Gene names
Name:RPS22A
Synonyms:RPS24, RPS24A
Ordered Locus Names:YJL190C
ORF Names:J0355
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.6

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01302_A.

Miscellaneous

Present with 40400 molecules/cell in log phase SD medium.

There are 2 genes for S22 in yeast.

Sequence similarities

Belongs to the ribosomal protein S8P family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5 Ref.7
Chain2 – 13012940S ribosomal protein S22-A HAMAP-Rule MF_01302_A
PRO_0000126623

Secondary structure

........................... 130
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C0W1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: ED34BEF6A5442CC9

FASTA13014,626
        10         20         30         40         50         60 
MTRSSVLADA LNAINNAEKT GKRQVLIRPS SKVIIKFLQV MQKHGYIGEF EYIDDHRSGK 

        70         80         90        100        110        120 
IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG YVILTTSAGI MDHEEARRKH 

       130 
VSGKILGFVY 

« Hide

References

« Hide 'large scale' references
[1]"The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed."
Leer R.J., van Raamsdonk-Duin M.M.C., Kraakman P., Mager W.H., Planta R.J.
Nucleic Acids Res. 13:701-709(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
Purnelle B., Coster F., Goffeau A.
Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
Otaka E., Higo K., Osawa S.
Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-44.
[6]"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
Planta R.J., Mager W.H.
Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE, SUBUNIT.
[7]"The action of N-terminal acetyltransferases on yeast ribosomal proteins."
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 4-130, ELECTRON MICROSCOPY.
[10]"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01962 Genomic DNA. Translation: CAA25998.1.
X77688 Genomic DNA. Translation: CAA54770.1.
Z49465 Genomic DNA. Translation: CAA89485.1.
BK006943 Genomic DNA. Translation: DAA08617.1.
PIRR4BY24. A23082.
RefSeqNP_012345.1. NM_001181623.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-H4-130[»]
1S1Helectron microscopy11.70H2-130[»]
3IZBelectron microscopy-H1-130[»]
3O2ZX-ray4.00O1-130[»]
3O30X-ray4.00O1-130[»]
3U5CX-ray3.00W1-130[»]
3U5GX-ray3.00W1-130[»]
4BYLelectron microscopy4.30W1-130[»]
4BYTelectron microscopy6.60W1-130[»]
ProteinModelPortalP0C0W1.
SMRP0C0W1. Positions 2-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33573. 132 interactions.
DIPDIP-5473N.
IntActP0C0W1. 36 interactions.
MINTMINT-479211.
STRING4932.YJL190C.

Proteomic databases

PeptideAtlasP0C0W1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL190C; YJL190C; YJL190C.
GeneID853249.
KEGGsce:YJL190C.

Organism-specific databases

SGDS000003726. RPS22A.

Phylogenomic databases

GeneTreeENSGT00390000003021.
HOGENOMHOG000204097.
KOK02957.
OMALPAKNFG.
OrthoDBEOG7RJQ47.

Enzyme and pathway databases

BioCycYEAST:G3O-31622-MONOMER.

Gene expression databases

GenevestigatorP0C0W1.

Family and domain databases

HAMAPMF_01302_A. Ribosomal_S8_A.
InterProIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERPTHR11758. PTHR11758. 1 hit.
PfamPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMSSF56047. SSF56047. 1 hit.
PROSITEPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0C0W1.
NextBio973490.

Entry information

Entry nameRS22A_YEAST
AccessionPrimary (citable) accession number: P0C0W1
Secondary accession number(s): D6VW01, P04648
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references