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P0C0W1

- RS22A_YEAST

UniProt

P0C0W1 - RS22A_YEAST

Protein

40S ribosomal protein S22-A

Gene

RPS22A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31622-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S22-A
    Alternative name(s):
    RP50
    S24
    YP58
    YS22
    Gene namesi
    Name:RPS22A
    Synonyms:RPS24, RPS24A
    Ordered Locus Names:YJL190C
    ORF Names:J0355
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome X

    Organism-specific databases

    SGDiS000003726. RPS22A.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 13012940S ribosomal protein S22-APRO_0000126623Add
    BLAST

    Proteomic databases

    PeptideAtlasiP0C0W1.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C0W1.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi33573. 132 interactions.
    DIPiDIP-5473N.
    IntActiP0C0W1. 36 interactions.
    MINTiMINT-479211.
    STRINGi4932.YJL190C.

    Structurei

    Secondary structure

    1
    130
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1914
    Beta strandi23 – 275
    Helixi32 – 4211
    Turni43 – 453
    Beta strandi50 – 534
    Beta strandi56 – 583
    Beta strandi60 – 645
    Beta strandi72 – 743
    Helixi85 – 939
    Beta strandi94 – 963
    Beta strandi97 – 993
    Beta strandi101 – 1066
    Beta strandi109 – 1124
    Helixi113 – 1197
    Beta strandi123 – 1297

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-H4-130[»]
    1S1Helectron microscopy11.70H2-130[»]
    1VW9electron microscopy6.10X1-130[»]
    1VWVelectron microscopy6.10X1-130[»]
    3IZBelectron microscopy-H1-130[»]
    3O2ZX-ray4.00O1-130[»]
    3O30X-ray4.00O1-130[»]
    3U5CX-ray3.00W1-130[»]
    3U5GX-ray3.00W1-130[»]
    4BYLelectron microscopy4.30W1-130[»]
    4BYTelectron microscopy6.60W1-130[»]
    4CUYelectron microscopy3.70W2-130[»]
    ProteinModelPortaliP0C0W1.
    SMRiP0C0W1. Positions 2-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0C0W1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S8P family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000003021.
    HOGENOMiHOG000204097.
    KOiK02957.
    OMAiLPAKNFG.
    OrthoDBiEOG7RJQ47.

    Family and domain databases

    HAMAPiMF_01302_A. Ribosomal_S8_A.
    InterProiIPR000630. Ribosomal_S8.
    [Graphical view]
    PANTHERiPTHR11758. PTHR11758. 1 hit.
    PfamiPF00410. Ribosomal_S8. 1 hit.
    [Graphical view]
    SUPFAMiSSF56047. SSF56047. 1 hit.
    PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C0W1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRSSVLADA LNAINNAEKT GKRQVLIRPS SKVIIKFLQV MQKHGYIGEF    50
    EYIDDHRSGK IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG 100
    YVILTTSAGI MDHEEARRKH VSGKILGFVY 130
    Length:130
    Mass (Da):14,626
    Last modified:January 23, 2007 - v2
    Checksum:iED34BEF6A5442CC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01962 Genomic DNA. Translation: CAA25998.1.
    X77688 Genomic DNA. Translation: CAA54770.1.
    Z49465 Genomic DNA. Translation: CAA89485.1.
    BK006943 Genomic DNA. Translation: DAA08617.1.
    PIRiA23082. R4BY24.
    RefSeqiNP_012345.1. NM_001181623.1.

    Genome annotation databases

    EnsemblFungiiYJL190C; YJL190C; YJL190C.
    GeneIDi853249.
    KEGGisce:YJL190C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01962 Genomic DNA. Translation: CAA25998.1 .
    X77688 Genomic DNA. Translation: CAA54770.1 .
    Z49465 Genomic DNA. Translation: CAA89485.1 .
    BK006943 Genomic DNA. Translation: DAA08617.1 .
    PIRi A23082. R4BY24.
    RefSeqi NP_012345.1. NM_001181623.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - H 4-130 [» ]
    1S1H electron microscopy 11.70 H 2-130 [» ]
    1VW9 electron microscopy 6.10 X 1-130 [» ]
    1VWV electron microscopy 6.10 X 1-130 [» ]
    3IZB electron microscopy - H 1-130 [» ]
    3O2Z X-ray 4.00 O 1-130 [» ]
    3O30 X-ray 4.00 O 1-130 [» ]
    3U5C X-ray 3.00 W 1-130 [» ]
    3U5G X-ray 3.00 W 1-130 [» ]
    4BYL electron microscopy 4.30 W 1-130 [» ]
    4BYT electron microscopy 6.60 W 1-130 [» ]
    4CUY electron microscopy 3.70 W 2-130 [» ]
    ProteinModelPortali P0C0W1.
    SMRi P0C0W1. Positions 2-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33573. 132 interactions.
    DIPi DIP-5473N.
    IntActi P0C0W1. 36 interactions.
    MINTi MINT-479211.
    STRINGi 4932.YJL190C.

    Proteomic databases

    PeptideAtlasi P0C0W1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YJL190C ; YJL190C ; YJL190C .
    GeneIDi 853249.
    KEGGi sce:YJL190C.

    Organism-specific databases

    SGDi S000003726. RPS22A.

    Phylogenomic databases

    GeneTreei ENSGT00390000003021.
    HOGENOMi HOG000204097.
    KOi K02957.
    OMAi LPAKNFG.
    OrthoDBi EOG7RJQ47.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31622-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0C0W1.
    NextBioi 973490.

    Gene expression databases

    Genevestigatori P0C0W1.

    Family and domain databases

    HAMAPi MF_01302_A. Ribosomal_S8_A.
    InterProi IPR000630. Ribosomal_S8.
    [Graphical view ]
    PANTHERi PTHR11758. PTHR11758. 1 hit.
    Pfami PF00410. Ribosomal_S8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56047. SSF56047. 1 hit.
    PROSITEi PS00053. RIBOSOMAL_S8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed."
      Leer R.J., van Raamsdonk-Duin M.M.C., Kraakman P., Mager W.H., Planta R.J.
      Nucleic Acids Res. 13:701-709(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
      Purnelle B., Coster F., Goffeau A.
      Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
      Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
      , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
      EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
      Otaka E., Higo K., Osawa S.
      Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-44.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 4-130, ELECTRON MICROSCOPY.
    10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS22A_YEAST
    AccessioniPrimary (citable) accession number: P0C0W1
    Secondary accession number(s): D6VW01, P04648
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 40400 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S22 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome X
      Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

    External Data

    Dasty 3