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P0C0W1 (RS22A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S22-A
Alternative name(s):
RP50
S24
YP58
YS22
Gene names
Name:RPS22A
Synonyms:RPS24, RPS24A
Ordered Locus Names:YJL190C
ORF Names:J0355
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.6

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01302_A.

Miscellaneous

Present with 40400 molecules/cell in log phase SD medium.

There are 2 genes for S22 in yeast.

Sequence similarities

Belongs to the ribosomal protein S8P family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5 Ref.7
Chain2 – 13012940S ribosomal protein S22-A HAMAP-Rule MF_01302_A
PRO_0000126623

Secondary structure

........................... 130
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0C0W1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: ED34BEF6A5442CC9

FASTA13014,626
        10         20         30         40         50         60 
MTRSSVLADA LNAINNAEKT GKRQVLIRPS SKVIIKFLQV MQKHGYIGEF EYIDDHRSGK 

        70         80         90        100        110        120 
IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG YVILTTSAGI MDHEEARRKH 

       130 
VSGKILGFVY 

« Hide

References

« Hide 'large scale' references
[1]"The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed."
Leer R.J., van Raamsdonk-Duin M.M.C., Kraakman P., Mager W.H., Planta R.J.
Nucleic Acids Res. 13:701-709(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
Purnelle B., Coster F., Goffeau A.
Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. expand/collapse author list , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
Otaka E., Higo K., Osawa S.
Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-44.
[6]"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
Planta R.J., Mager W.H.
Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE, SUBUNIT.
[7]"The action of N-terminal acetyltransferases on yeast ribosomal proteins."
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 4-130, ELECTRON MICROSCOPY.
[10]"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01962 Genomic DNA. Translation: CAA25998.1.
X77688 Genomic DNA. Translation: CAA54770.1.
Z49465 Genomic DNA. Translation: CAA89485.1.
BK006943 Genomic DNA. Translation: DAA08617.1.
PIRR4BY24. A23082.
RefSeqNP_012345.1. NM_001181623.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-H4-130[»]
1S1Helectron microscopy11.70H2-130[»]
3IZBelectron microscopy-H1-130[»]
3O2ZX-ray4.00O1-130[»]
3O30X-ray4.00O1-130[»]
3U5CX-ray3.00W1-130[»]
3U5GX-ray3.00W1-130[»]
4BYLelectron microscopy4.30W1-130[»]
4BYTelectron microscopy6.60W1-130[»]
ProteinModelPortalP0C0W1.
SMRP0C0W1. Positions 2-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33573. 132 interactions.
DIPDIP-5473N.
IntActP0C0W1. 36 interactions.
MINTMINT-479211.
STRING4932.YJL190C.

Proteomic databases

PeptideAtlasP0C0W1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYJL190C; YJL190C; YJL190C.
GeneID853249.
KEGGsce:YJL190C.

Organism-specific databases

SGDS000003726. RPS22A.

Phylogenomic databases

GeneTreeENSGT00390000003021.
HOGENOMHOG000204097.
KOK02957.
OMALPAKNFG.
OrthoDBEOG7RJQ47.

Enzyme and pathway databases

BioCycYEAST:G3O-31622-MONOMER.

Gene expression databases

GenevestigatorP0C0W1.

Family and domain databases

HAMAPMF_01302_A. Ribosomal_S8_A.
InterProIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERPTHR11758. PTHR11758. 1 hit.
PfamPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMSSF56047. SSF56047. 1 hit.
PROSITEPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0C0W1.
NextBio973490.

Entry information

Entry nameRS22A_YEAST
AccessionPrimary (citable) accession number: P0C0W1
Secondary accession number(s): D6VW01, P04648
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome X

Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references