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Protein

40S ribosomal protein S22-A

Gene

RPS22A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31622-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S22-A
Alternative name(s):
RP50
S24
YP58
YS22
Gene namesi
Name:RPS22A
Synonyms:RPS24, RPS24A
Ordered Locus Names:YJL190C
ORF Names:J0355
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL190C.
SGDiS000003726. RPS22A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001266232 – 13040S ribosomal protein S22-AAdd BLAST129

Proteomic databases

MaxQBiP0C0W1.
PRIDEiP0C0W1.
TopDownProteomicsiP0C0W1.

PTM databases

iPTMnetiP0C0W1.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33573. 64 interactors.
DIPiDIP-5473N.
IntActiP0C0W1. 37 interactors.
MINTiMINT-479211.

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 19Combined sources14
Beta strandi23 – 29Combined sources7
Helixi32 – 43Combined sources12
Beta strandi50 – 53Combined sources4
Beta strandi56 – 58Combined sources3
Beta strandi60 – 64Combined sources5
Beta strandi70 – 74Combined sources5
Helixi85 – 93Combined sources9
Beta strandi94 – 96Combined sources3
Beta strandi97 – 99Combined sources3
Beta strandi101 – 106Combined sources6
Beta strandi109 – 112Combined sources4
Helixi113 – 119Combined sources7
Beta strandi123 – 130Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-H4-130[»]
3J6Xelectron microscopy6.10221-130[»]
3J6Yelectron microscopy6.10221-130[»]
3J77electron microscopy6.20221-130[»]
3J78electron microscopy6.30221-130[»]
3V88X-ray3.00W1-130[»]
4U3MX-ray3.00D2/d22-130[»]
4U3NX-ray3.20D2/d22-130[»]
4U3UX-ray2.90D2/d22-130[»]
4U4NX-ray3.10D2/d22-130[»]
4U4OX-ray3.60D2/d22-130[»]
4U4QX-ray3.00D2/d22-130[»]
4U4RX-ray2.80D2/d22-130[»]
4U4UX-ray3.00D2/d22-130[»]
4U4YX-ray3.20D2/d22-130[»]
4U4ZX-ray3.10D2/d22-130[»]
4U50X-ray3.20D2/d22-130[»]
4U51X-ray3.20D2/d22-130[»]
4U52X-ray3.00D2/d22-130[»]
4U53X-ray3.30D2/d22-130[»]
4U55X-ray3.20D2/d22-130[»]
4U56X-ray3.45D2/d22-130[»]
4U6FX-ray3.10D2/d22-130[»]
4V4Belectron microscopy11.70AH2-130[»]
4V6Ielectron microscopy8.80AH1-130[»]
4V7RX-ray4.00AO/CO1-130[»]
4V88X-ray3.00AW/CW1-130[»]
4V8Yelectron microscopy4.30AW1-130[»]
4V8Zelectron microscopy6.60AW1-130[»]
4V92electron microscopy3.70W2-130[»]
5DATX-ray3.15D22-130[»]
d22-130[»]
5DC3X-ray3.25D2/d22-130[»]
5FCIX-ray3.40D2/d22-130[»]
5FCJX-ray3.10D2/d22-130[»]
5I4LX-ray3.10D2/d22-130[»]
5JPQelectron microscopy7.30z1-130[»]
5JUOelectron microscopy4.00TB1-130[»]
5JUPelectron microscopy3.50TB1-130[»]
5JUSelectron microscopy4.20TB1-130[»]
5JUTelectron microscopy4.00TB1-130[»]
5JUUelectron microscopy4.00TB1-130[»]
ProteinModelPortaliP0C0W1.
SMRiP0C0W1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0W1.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8P family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
InParanoidiP0C0W1.
KOiK02957.
OMAiSHITNSE.
OrthoDBiEOG092C5DJJ.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A. 1 hit.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSSVLADA LNAINNAEKT GKRQVLIRPS SKVIIKFLQV MQKHGYIGEF
60 70 80 90 100
EYIDDHRSGK IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG
110 120 130
YVILTTSAGI MDHEEARRKH VSGKILGFVY
Length:130
Mass (Da):14,626
Last modified:January 23, 2007 - v2
Checksum:iED34BEF6A5442CC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01962 Genomic DNA. Translation: CAA25998.1.
X77688 Genomic DNA. Translation: CAA54770.1.
Z49465 Genomic DNA. Translation: CAA89485.1.
BK006943 Genomic DNA. Translation: DAA08617.1.
PIRiA23082. R4BY24.
RefSeqiNP_012345.1. NM_001181623.1.

Genome annotation databases

EnsemblFungiiYJL190C; YJL190C; YJL190C.
GeneIDi853249.
KEGGisce:YJL190C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01962 Genomic DNA. Translation: CAA25998.1.
X77688 Genomic DNA. Translation: CAA54770.1.
Z49465 Genomic DNA. Translation: CAA89485.1.
BK006943 Genomic DNA. Translation: DAA08617.1.
PIRiA23082. R4BY24.
RefSeqiNP_012345.1. NM_001181623.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-H4-130[»]
3J6Xelectron microscopy6.10221-130[»]
3J6Yelectron microscopy6.10221-130[»]
3J77electron microscopy6.20221-130[»]
3J78electron microscopy6.30221-130[»]
3V88X-ray3.00W1-130[»]
4U3MX-ray3.00D2/d22-130[»]
4U3NX-ray3.20D2/d22-130[»]
4U3UX-ray2.90D2/d22-130[»]
4U4NX-ray3.10D2/d22-130[»]
4U4OX-ray3.60D2/d22-130[»]
4U4QX-ray3.00D2/d22-130[»]
4U4RX-ray2.80D2/d22-130[»]
4U4UX-ray3.00D2/d22-130[»]
4U4YX-ray3.20D2/d22-130[»]
4U4ZX-ray3.10D2/d22-130[»]
4U50X-ray3.20D2/d22-130[»]
4U51X-ray3.20D2/d22-130[»]
4U52X-ray3.00D2/d22-130[»]
4U53X-ray3.30D2/d22-130[»]
4U55X-ray3.20D2/d22-130[»]
4U56X-ray3.45D2/d22-130[»]
4U6FX-ray3.10D2/d22-130[»]
4V4Belectron microscopy11.70AH2-130[»]
4V6Ielectron microscopy8.80AH1-130[»]
4V7RX-ray4.00AO/CO1-130[»]
4V88X-ray3.00AW/CW1-130[»]
4V8Yelectron microscopy4.30AW1-130[»]
4V8Zelectron microscopy6.60AW1-130[»]
4V92electron microscopy3.70W2-130[»]
5DATX-ray3.15D22-130[»]
d22-130[»]
5DC3X-ray3.25D2/d22-130[»]
5FCIX-ray3.40D2/d22-130[»]
5FCJX-ray3.10D2/d22-130[»]
5I4LX-ray3.10D2/d22-130[»]
5JPQelectron microscopy7.30z1-130[»]
5JUOelectron microscopy4.00TB1-130[»]
5JUPelectron microscopy3.50TB1-130[»]
5JUSelectron microscopy4.20TB1-130[»]
5JUTelectron microscopy4.00TB1-130[»]
5JUUelectron microscopy4.00TB1-130[»]
ProteinModelPortaliP0C0W1.
SMRiP0C0W1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33573. 64 interactors.
DIPiDIP-5473N.
IntActiP0C0W1. 37 interactors.
MINTiMINT-479211.

PTM databases

iPTMnetiP0C0W1.

Proteomic databases

MaxQBiP0C0W1.
PRIDEiP0C0W1.
TopDownProteomicsiP0C0W1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL190C; YJL190C; YJL190C.
GeneIDi853249.
KEGGisce:YJL190C.

Organism-specific databases

EuPathDBiFungiDB:YJL190C.
SGDiS000003726. RPS22A.

Phylogenomic databases

GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
InParanoidiP0C0W1.
KOiK02957.
OMAiSHITNSE.
OrthoDBiEOG092C5DJJ.

Enzyme and pathway databases

BioCyciYEAST:G3O-31622-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP0C0W1.
PROiP0C0W1.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A. 1 hit.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS22A_YEAST
AccessioniPrimary (citable) accession number: P0C0W1
Secondary accession number(s): D6VW01, P04648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 40400 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for S22 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.