SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C0W1

- RS22A_YEAST

UniProt

P0C0W1 - RS22A_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

40S ribosomal protein S22-A

Gene
RPS22A, RPS24, RPS24A, YJL190C, J0355
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31622-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S22-A
Alternative name(s):
RP50
S24
YP58
YS22
Gene namesi
Name:RPS22A
Synonyms:RPS24, RPS24A
Ordered Locus Names:YJL190C
ORF Names:J0355
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

SGDiS000003726. RPS22A.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 13012940S ribosomal protein S22-AUniRule annotationPRO_0000126623Add
BLAST

Proteomic databases

PeptideAtlasiP0C0W1.

Expressioni

Gene expression databases

GenevestigatoriP0C0W1.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33573. 132 interactions.
DIPiDIP-5473N.
IntActiP0C0W1. 36 interactions.
MINTiMINT-479211.
STRINGi4932.YJL190C.

Structurei

Secondary structure

1
130
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1914
Beta strandi23 – 275
Helixi32 – 4211
Turni43 – 453
Beta strandi50 – 534
Beta strandi56 – 583
Beta strandi60 – 645
Beta strandi72 – 743
Helixi85 – 939
Beta strandi94 – 963
Beta strandi97 – 993
Beta strandi101 – 1066
Beta strandi109 – 1124
Helixi113 – 1197
Beta strandi123 – 1297

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-H4-130[»]
1S1Helectron microscopy11.70H2-130[»]
1VW9electron microscopy6.10X1-130[»]
1VWVelectron microscopy6.10X1-130[»]
3IZBelectron microscopy-H1-130[»]
3O2ZX-ray4.00O1-130[»]
3O30X-ray4.00O1-130[»]
3U5CX-ray3.00W1-130[»]
3U5GX-ray3.00W1-130[»]
4BYLelectron microscopy4.30W1-130[»]
4BYTelectron microscopy6.60W1-130[»]
4CUYelectron microscopy3.70W2-130[»]
ProteinModelPortaliP0C0W1.
SMRiP0C0W1. Positions 2-130.

Miscellaneous databases

EvolutionaryTraceiP0C0W1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
KOiK02957.
OMAiLPAKNFG.
OrthoDBiEOG7RJQ47.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0W1-1 [UniParc]FASTAAdd to Basket

« Hide

MTRSSVLADA LNAINNAEKT GKRQVLIRPS SKVIIKFLQV MQKHGYIGEF    50
EYIDDHRSGK IVVQLNGRLN KCGVISPRFN VKIGDIEKWT ANLLPARQFG 100
YVILTTSAGI MDHEEARRKH VSGKILGFVY 130
Length:130
Mass (Da):14,626
Last modified:January 23, 2007 - v2
Checksum:iED34BEF6A5442CC9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01962 Genomic DNA. Translation: CAA25998.1.
X77688 Genomic DNA. Translation: CAA54770.1.
Z49465 Genomic DNA. Translation: CAA89485.1.
BK006943 Genomic DNA. Translation: DAA08617.1.
PIRiA23082. R4BY24.
RefSeqiNP_012345.1. NM_001181623.1.

Genome annotation databases

EnsemblFungiiYJL190C; YJL190C; YJL190C.
GeneIDi853249.
KEGGisce:YJL190C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01962 Genomic DNA. Translation: CAA25998.1 .
X77688 Genomic DNA. Translation: CAA54770.1 .
Z49465 Genomic DNA. Translation: CAA89485.1 .
BK006943 Genomic DNA. Translation: DAA08617.1 .
PIRi A23082. R4BY24.
RefSeqi NP_012345.1. NM_001181623.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5X model - H 4-130 [» ]
1S1H electron microscopy 11.70 H 2-130 [» ]
1VW9 electron microscopy 6.10 X 1-130 [» ]
1VWV electron microscopy 6.10 X 1-130 [» ]
3IZB electron microscopy - H 1-130 [» ]
3O2Z X-ray 4.00 O 1-130 [» ]
3O30 X-ray 4.00 O 1-130 [» ]
3U5C X-ray 3.00 W 1-130 [» ]
3U5G X-ray 3.00 W 1-130 [» ]
4BYL electron microscopy 4.30 W 1-130 [» ]
4BYT electron microscopy 6.60 W 1-130 [» ]
4CUY electron microscopy 3.70 W 2-130 [» ]
ProteinModelPortali P0C0W1.
SMRi P0C0W1. Positions 2-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33573. 132 interactions.
DIPi DIP-5473N.
IntActi P0C0W1. 36 interactions.
MINTi MINT-479211.
STRINGi 4932.YJL190C.

Proteomic databases

PeptideAtlasi P0C0W1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL190C ; YJL190C ; YJL190C .
GeneIDi 853249.
KEGGi sce:YJL190C.

Organism-specific databases

SGDi S000003726. RPS22A.

Phylogenomic databases

GeneTreei ENSGT00390000003021.
HOGENOMi HOG000204097.
KOi K02957.
OMAi LPAKNFG.
OrthoDBi EOG7RJQ47.

Enzyme and pathway databases

BioCyci YEAST:G3O-31622-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

EvolutionaryTracei P0C0W1.
NextBioi 973490.

Gene expression databases

Genevestigatori P0C0W1.

Family and domain databases

HAMAPi MF_01302_A. Ribosomal_S8_A.
InterProi IPR000630. Ribosomal_S8.
[Graphical view ]
PANTHERi PTHR11758. PTHR11758. 1 hit.
Pfami PF00410. Ribosomal_S8. 1 hit.
[Graphical view ]
SUPFAMi SSF56047. SSF56047. 1 hit.
PROSITEi PS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed."
    Leer R.J., van Raamsdonk-Duin M.M.C., Kraakman P., Mager W.H., Planta R.J.
    Nucleic Acids Res. 13:701-709(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes."
    Purnelle B., Coster F., Goffeau A.
    Yeast 10:1235-1249(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
    Otaka E., Higo K., Osawa S.
    Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-44.
  6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 4-130, ELECTRON MICROSCOPY.
  10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.

Entry informationi

Entry nameiRS22A_YEAST
AccessioniPrimary (citable) accession number: P0C0W1
Secondary accession number(s): D6VW01, P04648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 40400 molecules/cell in log phase SD medium.
There are 2 genes for S22 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3

Similar proteinsi