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Protein

Protein PB1-F2

Gene

PB1

Organism
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.UniRule annotation1 Publication

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Low pathogenicityUniRule annotation1

GO - Biological processi

  • active induction of host immune response by virus Source: Reactome
  • modulation by virus of host apoptotic process Source: UniProtKB-KW
  • negative regulation of interferon-beta secretion Source: CACAO
  • suppression by virus of host MAVS activity Source: UniProtKB

Keywordsi

Biological processApoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Enzyme and pathway databases

ReactomeiR-HSA-168277 Influenza Virus Induced Apoptosis
R-HSA-192823 Viral mRNA Translation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PB1-F2UniRule annotation
Gene namesi
Name:PB1UniRule annotation
OrganismiInfluenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Taxonomic identifieri211044 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000170967 Componenti: Genome
  • UP000009255 Componenti: Genome

Subcellular locationi

  • Host mitochondrion inner membrane UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication
  • host cytosol UniRule annotation1 Publication
  • Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000787431 – 87Protein PB1-F2Add BLAST87

Interactioni

Subunit structurei

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.UniRule annotation1 Publication

Protein-protein interaction databases

IntActiP0C0U1, 15 interactors

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 62Combined sources11
Helixi65 – 86Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HN8NMR-A50-87[»]
3BUYX-ray2.60C62-70[»]
ProteinModelPortaliP0C0U1
SMRiP0C0U1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0U1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 87Mitochondrial targeting sequenceUniRule annotationAdd BLAST23

Sequence similaritiesi

Belongs to the influenza viruses PB1-F2 family.UniRule annotation

Phylogenomic databases

KOiK19397
OrthoDBiVOG090001GF

Family and domain databases

HAMAPiMF_04064 INFV_PB1F2, 1 hit
InterProiView protein in InterPro
IPR021045 Flu_proapoptotic_PB1-F2
PfamiView protein in Pfam
PF11986 PB1-F2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQEQDTPWI LSTGHISTQK RQDGQQTPKL EHRNSTRLMG HCQKTMNQVV
60 70 80
MPKQIVYWKQ WLSLRNPILV FLKTRVLKRW RLFSKHE
Length:87
Mass (Da):10,483
Last modified:December 6, 2005 - v1
Checksum:i832A7E34E350B454
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti22Q → E. 1
Natural varianti59 – 60KQ → RR. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02151 Genomic RNA No translation available.
EF467819 Genomic RNA Translation: ABO21707.1
CY009450 Genomic RNA Translation: ABD77684.1
RefSeqiYP_418248.1, NC_002021.1

Genome annotation databases

GeneIDi3802042
KEGGivg:3802042

Similar proteinsi

Entry informationi

Entry nameiPB1F2_I34A1
AccessioniPrimary (citable) accession number: P0C0U1
Secondary accession number(s): A4GXH2, Q20N29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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