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Protein

Protein PB1-F2

Gene

PB1

Organism
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.UniRule annotation1 Publication

Miscellaneous

Is not encoded in all strains, and seems to be dispensable for replication.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Low pathogenicityUniRule annotation1

GO - Biological processi

Keywordsi

Biological processApoptosis, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host MAVS by virus, Inhibition of host RLR pathway by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Enzyme and pathway databases

ReactomeiR-HSA-168277. Influenza Virus Induced Apoptosis.
R-HSA-192823. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PB1-F2UniRule annotation
Gene namesi
Name:PB1UniRule annotation
OrganismiInfluenza A virus (strain A/Puerto Rico/8/1934 H1N1)
Taxonomic identifieri211044 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000170967 Componenti: Genome
  • UP000009255 Componenti: Genome
  • UP000109386 Componenti: Genome

Subcellular locationi

  • Host mitochondrion inner membrane UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication
  • Host cytoplasmhost cytosol UniRule annotation1 Publication

  • Note: Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Host mitochondrion, Host mitochondrion inner membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000787431 – 87Protein PB1-F2Add BLAST87

Interactioni

Subunit structurei

Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. Interacts with host MAVS.UniRule annotation1 Publication

Protein-protein interaction databases

IntActiP0C0U1. 15 interactors.

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 62Combined sources11
Helixi65 – 86Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HN8NMR-A50-87[»]
3BUYX-ray2.60C62-70[»]
ProteinModelPortaliP0C0U1.
SMRiP0C0U1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0U1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 87Mitochondrial targeting sequenceUniRule annotationAdd BLAST23

Sequence similaritiesi

Belongs to the influenza viruses PB1-F2 family.UniRule annotation

Phylogenomic databases

KOiK19397.
OrthoDBiVOG090001GF.

Family and domain databases

HAMAPiMF_04064. INFV_PB1F2. 1 hit.
InterProiView protein in InterPro
IPR021045. Flu_proapoptotic_PB1-F2.
PfamiView protein in Pfam
PF11986. PB1-F2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQEQDTPWI LSTGHISTQK RQDGQQTPKL EHRNSTRLMG HCQKTMNQVV
60 70 80
MPKQIVYWKQ WLSLRNPILV FLKTRVLKRW RLFSKHE
Length:87
Mass (Da):10,483
Last modified:December 6, 2005 - v1
Checksum:i832A7E34E350B454
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti22Q → E. 1
Natural varianti59 – 60KQ → RR. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02151 Genomic RNA. No translation available.
EF467819 Genomic RNA. Translation: ABO21707.1.
CY009450 Genomic RNA. Translation: ABD77684.1.
RefSeqiYP_418248.1. NC_002021.1.

Genome annotation databases

GeneIDi3802042.
KEGGivg:3802042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02151 Genomic RNA. No translation available.
EF467819 Genomic RNA. Translation: ABO21707.1.
CY009450 Genomic RNA. Translation: ABD77684.1.
RefSeqiYP_418248.1. NC_002021.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HN8NMR-A50-87[»]
3BUYX-ray2.60C62-70[»]
ProteinModelPortaliP0C0U1.
SMRiP0C0U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0C0U1. 15 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3802042.
KEGGivg:3802042.

Phylogenomic databases

KOiK19397.
OrthoDBiVOG090001GF.

Enzyme and pathway databases

ReactomeiR-HSA-168277. Influenza Virus Induced Apoptosis.
R-HSA-192823. Viral mRNA Translation.

Miscellaneous databases

EvolutionaryTraceiP0C0U1.

Family and domain databases

HAMAPiMF_04064. INFV_PB1F2. 1 hit.
InterProiView protein in InterPro
IPR021045. Flu_proapoptotic_PB1-F2.
PfamiView protein in Pfam
PF11986. PB1-F2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPB1F2_I34A1
AccessioniPrimary (citable) accession number: P0C0U1
Secondary accession number(s): A4GXH2, Q20N29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.