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Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB.By similarity

Pathwayi: capsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
Biological processCapsule biogenesis/degradation, Exopolysaccharide synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00934

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Synonyms:cpsIaD
OrganismiStreptococcus agalactiae
Taxonomic identifieri1311 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002172371 – 229Tyrosine-protein kinase CpsDAdd BLAST229

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP0C0T9

Structurei

3D structure databases

ProteinModelPortaliP0C0T9
SMRiP0C0T9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.Curated

Phylogenomic databases

eggNOGiENOG4105D75 Bacteria
COG0489 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR025669 AAA_dom
IPR005702 EPS_synthesis
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13614 AAA_31, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01007 eps_fam, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS
60 70 80 90 100
TTSTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA
110 120 130 140 150
DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII
160 170 180 190 200
IDTPPIGLVV DAAIIASACD GFVLVTQAGR IKRNYVEKAK EQMEQSGSKF
210 220
LGIILNKVNE SVATYGDYGN YGKRDRKRK
Length:229
Mass (Da):25,053
Last modified:December 6, 2005 - v1
Checksum:iAD8133B41ECAC237
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti54T → I in strain: CNTC 1/82. 1
Natural varianti167S → N in strain: CNTC 1/82. 1
Natural varianti173V → I in strain: CNTC 1/82. 1
Natural varianti219G → GDYG in strain: CNTC 1/82. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337958 Genomic DNA Translation: AAK11661.1
AF355776 Genomic DNA Translation: AAK43605.1
RefSeqiWP_000197406.1, NZ_MBLL01000044.1
WP_000197418.1, NZ_CP021868.1

Similar proteinsi

Entry informationi

Entry nameiCPSD_STRAG
AccessioniPrimary (citable) accession number: P0C0T9
Secondary accession number(s): Q93TJ2, Q9ALX5, Q9S0S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health