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P0C0T9

- CPSD_STRAG

UniProt

P0C0T9 - CPSD_STRAG

Protein

Tyrosine-protein kinase CpsD

Gene

cpsD

Organism
Streptococcus agalactiae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

    Enzyme regulationi

    Dephosphorylated and activated by CpsB.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. enzyme regulator activity Source: InterPro
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Exopolysaccharide synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase CpsD (EC:2.7.10.2)
    Gene namesi
    Name:cpsD
    Synonyms:cpsIaD
    OrganismiStreptococcus agalactiae
    Taxonomic identifieri1311 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Tyrosine-protein kinase CpsDPRO_0000217237Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CpsD/CapB family.Curated

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13614. AAA_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01007. eps_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C0T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS    50
    TTSTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA 100
    DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII 150
    IDTPPIGLVV DAAIIASACD GFVLVTQAGR IKRNYVEKAK EQMEQSGSKF 200
    LGIILNKVNE SVATYGDYGN YGKRDRKRK 229
    Length:229
    Mass (Da):25,053
    Last modified:December 6, 2005 - v1
    Checksum:iAD8133B41ECAC237
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541T → I in strain: CNTC 1/82.
    Natural varianti167 – 1671S → N in strain: CNTC 1/82.
    Natural varianti173 – 1731V → I in strain: CNTC 1/82.
    Natural varianti219 – 2191G → GDYG in strain: CNTC 1/82.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337958 Genomic DNA. Translation: AAK11661.1.
    AF355776 Genomic DNA. Translation: AAK43605.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337958 Genomic DNA. Translation: AAK11661.1 .
    AF355776 Genomic DNA. Translation: AAK43605.1 .

    3D structure databases

    ProteinModelPortali P0C0T9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00934 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR005702. EPS_synthesis.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13614. AAA_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01007. eps_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. McKinnon K., Chaffin D.O., Rubens C.E.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NT6 / Serotype VI.
    2. McKinnon K., Chaffin D.O., Rubens C.E.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

    Entry informationi

    Entry nameiCPSD_STRAG
    AccessioniPrimary (citable) accession number: P0C0T9
    Secondary accession number(s): Q93TJ2, Q9ALX5, Q9S0S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3