P0C0T9 (CPSD_STRAG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase CpsD
EC=2.7.10.2

Gene names

Name:	cpsD
Synonyms:	cpsIaD

Organism

Streptococcus agalactiae

Taxonomic identifier

1311 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Enzyme regulation	Dephosphorylated and activated by CpsB By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the CpsD/CapB family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of catalytic activity Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW enzyme regulator activity Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Tyrosine-protein kinase CpsD		PRO_0000217237
Natural variations
	Natural variant	54	1	T → I in strain: CNTC 1/82.
	Natural variant	167	1	S → N in strain: CNTC 1/82.
	Natural variant	173	1	V → I in strain: CNTC 1/82.
	Natural variant	219	1	G → GDYG in strain: CNTC 1/82.

Sequences

	Sequence		Length	Mass (Da)
	P0C0T9 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: AD8133B41ECAC237	FASTA	229	25,053
	10 20 30 40 50 60 MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS TTSTSLALSL 70 80 90 100 110 120 AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA DLGDIICETN VPRLMVVPSG 130 140 150 160 170 180 KVPPNPTALL QNAYFNKMIE AIKNIFDYII IDTPPIGLVV DAAIIASACD GFVLVTQAGR 190 200 210 220 IKRNYVEKAK EQMEQSGSKF LGIILNKVNE SVATYGDYGN YGKRDRKRK

References

[1]	McKinnon K., Chaffin D.O., Rubens C.E. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NT6 / Serotype VI.
[2]	McKinnon K., Chaffin D.O., Rubens C.E. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF337958 Genomic DNA. Translation: AAK11661.1. AF355776 Genomic DNA. Translation: AAK43605.1.
3D structure databases
ProteinModelPortal	P0C0T9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00934.
Family and domain databases
InterPro	IPR025669. AAA_dom. IPR005702. EPS_synthesis. [Graphical view]
Pfam	PF13614. AAA_31. 1 hit. [Graphical view]
TIGRFAMs	TIGR01007. eps_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSD_STRAG

Accession

Primary (citable) accession number: P0C0T9
Secondary accession number(s): Q93TJ2, Q9ALX5, Q9S0S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	January 9, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program