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P0C0T9

- CPSD_STRAG

UniProt

P0C0T9 - CPSD_STRAG

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Protein
Tyrosine-protein kinase CpsD
Gene
cpsD, cpsIaD
Organism
Streptococcus agalactiae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Dephosphorylated and activated by CpsB By similarity.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. enzyme regulator activity Source: InterPro
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase CpsD (EC:2.7.10.2)
Gene namesi
Name:cpsD
Synonyms:cpsIaD
OrganismiStreptococcus agalactiae
Taxonomic identifieri1311 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Tyrosine-protein kinase CpsD
PRO_0000217237Add
BLAST

Post-translational modificationi

Autophosphorylated By similarity.

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP0C0T9.

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsD/CapB family.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0T9-1 [UniParc]FASTAAdd to Basket

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MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS    50
TTSTSLALSL AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA 100
DLGDIICETN VPRLMVVPSG KVPPNPTALL QNAYFNKMIE AIKNIFDYII 150
IDTPPIGLVV DAAIIASACD GFVLVTQAGR IKRNYVEKAK EQMEQSGSKF 200
LGIILNKVNE SVATYGDYGN YGKRDRKRK 229
Length:229
Mass (Da):25,053
Last modified:December 6, 2005 - v1
Checksum:iAD8133B41ECAC237
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541T → I in strain: CNTC 1/82.
Natural varianti167 – 1671S → N in strain: CNTC 1/82.
Natural varianti173 – 1731V → I in strain: CNTC 1/82.
Natural varianti219 – 2191G → GDYG in strain: CNTC 1/82.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337958 Genomic DNA. Translation: AAK11661.1.
AF355776 Genomic DNA. Translation: AAK43605.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337958 Genomic DNA. Translation: AAK11661.1 .
AF355776 Genomic DNA. Translation: AAK43605.1 .

3D structure databases

ProteinModelPortali P0C0T9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00934 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13614. AAA_31. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01007. eps_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NT6 / Serotype VI.
  2. McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

Entry informationi

Entry nameiCPSD_STRAG
AccessioniPrimary (citable) accession number: P0C0T9
Secondary accession number(s): Q93TJ2, Q9ALX5, Q9S0S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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