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P0C0T9 (CPSD_STRAG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase CpsD

EC=2.7.10.2
Gene names
Name:cpsD
Synonyms:cpsIaD
OrganismStreptococcus agalactiae
Taxonomic identifier1311 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of capsular polysaccharide biosynthesis. Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation. May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulation

Dephosphorylated and activated by CpsB By similarity.

Pathway

Capsule biogenesis; capsule polysaccharide biosynthesis.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the CpsD/CapB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Tyrosine-protein kinase CpsD
PRO_0000217237

Natural variations

Natural variant541T → I in strain: CNTC 1/82.
Natural variant1671S → N in strain: CNTC 1/82.
Natural variant1731V → I in strain: CNTC 1/82.
Natural variant2191G → GDYG in strain: CNTC 1/82.

Sequences

Sequence LengthMass (Da)Tools
P0C0T9 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: AD8133B41ECAC237

FASTA22925,053
        10         20         30         40         50         60 
MTRLEIVDSK LRQAKKTEEY FNAIRTNIQF SGKENKILAI TSVREGEGKS TTSTSLALSL 

        70         80         90        100        110        120 
AQAGFKTLLI DADTRNSVMS GTFKATGTIK GLTNYLSGNA DLGDIICETN VPRLMVVPSG 

       130        140        150        160        170        180 
KVPPNPTALL QNAYFNKMIE AIKNIFDYII IDTPPIGLVV DAAIIASACD GFVLVTQAGR 

       190        200        210        220 
IKRNYVEKAK EQMEQSGSKF LGIILNKVNE SVATYGDYGN YGKRDRKRK 

« Hide

References

[1]McKinnon K., Chaffin D.O., Rubens C.E.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NT6 / Serotype VI.
[2]McKinnon K., Chaffin D.O., Rubens C.E.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF337958 Genomic DNA. Translation: AAK11661.1.
AF355776 Genomic DNA. Translation: AAK43605.1.

3D structure databases

ProteinModelPortalP0C0T9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00934.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13614. AAA_31. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01007. eps_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPSD_STRAG
AccessionPrimary (citable) accession number: P0C0T9
Secondary accession number(s): Q93TJ2, Q9ALX5, Q9S0S7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways