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Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus agalactiae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mn2+By similarity

Pathwayi

GO - Molecular functioni

  1. manganese ion binding Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:cpsIaB
OrganismiStreptococcus agalactiae
Taxonomic identifieri1311 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057887Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0C0T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.Curated

Phylogenomic databases

eggNOGiCOG4464.
KOiK01104.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET
60 70 80 90 100
PEDIIFKNFS IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN
110 120 130 140 150
NTKFALIEFS MQTSWKDIHT ALSNVLMLGI TPVVAHIERY NALENQKERV
160 170 180 190 200
KEIINMGCYT QINSSHILKQ KLFNDKHKRF KKRARYFLEE NLVHFVASDM
210 220 230 240
HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI
Length:243
Mass (Da):28,600
Last modified:December 6, 2005 - v1
Checksum:i319CA48CCB310123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337958 Genomic DNA. Translation: AAK11659.1.
AF355776 Genomic DNA. Translation: AAK43603.1.
RefSeqiWP_000565383.1. NZ_JPOV01000001.1.
YP_007968738.1. NC_021195.1.

Genome annotation databases

GeneIDi15485505.
KEGGisagl:GBS222_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337958 Genomic DNA. Translation: AAK11659.1.
AF355776 Genomic DNA. Translation: AAK43603.1.
RefSeqiWP_000565383.1. NZ_JPOV01000001.1.
YP_007968738.1. NC_021195.1.

3D structure databases

ProteinModelPortaliP0C0T7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15485505.
KEGGisagl:GBS222_1004.

Phylogenomic databases

eggNOGiCOG4464.
KOiK01104.

Enzyme and pathway databases

UniPathwayiUPA00934.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NT6 / Serotype VI.
  2. McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

Entry informationi

Entry nameiCPSB_STRAG
AccessioniPrimary (citable) accession number: P0C0T7
Secondary accession number(s): P0A365, Q9S0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.