Reviewed, UniProtKB/Swiss-Prot P0C0T7 (CPSB_STRAG)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase cpsB
    EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	cpsIaB

Organism

Streptococcus agalactiae

Taxonomic identifier

1311 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Dephosphorylates cpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the cpsB/capC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Tyrosine-protein phosphatase cpsB		PRO_0000057887

Sequences

	Sequence		Length	Mass (Da)
	P0C0T7-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 319CA48CCB310123	FASTA	243	28,600
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS 70 80 90 100 110 120 IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT 130 140 150 160 170 180 ALSNVLMLGI TPVVAHIERY NALENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF 190 200 210 220 230 240 KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI

References

[1]	McKinnon K., Chaffin D.O., Rubens C.E. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NT6 / Serotype VI.
[2]	McKinnon K., Chaffin D.O., Rubens C.E. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49446 / 3139 / CNCTC 1/82 / Serotype IV.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF337958 Genomic DNA. Translation: AAK11659.1. AF355776 Genomic DNA. Translation: AAK43603.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.3.48. 3065.
Family and domain databases
InterPro	IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view]
Pfam	PF02811. PHP. 1 hit. [Graphical view]
PIRSF	PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSB_STRAG

Accession

Primary (citable) accession number: P0C0T7
Secondary accession number(s): P0A365, Q9S0S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)