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Protein

Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Gene

Litaf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Short name:
LPS-induced TNF-alpha factor homolog
Alternative name(s):
Estrogen-enhanced transcript protein 1
Short name:
Eet-1
Gene namesi
Name:Litaf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69294. Litaf.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular region Source: RGD
  • Golgi apparatus Source: UniProtKB
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB-KW
  • nucleoplasm Source: Ensembl
  • plasma membrane Source: Ensembl

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844421 – 161Lipopolysaccharide-induced tumor necrosis factor-alpha factor homologAdd BLAST161

Proteomic databases

PaxDbiP0C0T0.
PRIDEiP0C0T0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By estrogen in vagina, cervix, uterus and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000002520.
ExpressionAtlasiP0C0T0. baseline and differential.
GenevisibleiP0C0T0. RN.

Interactioni

Subunit structurei

Interacts with WWOX. Interacts with NEDD4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 159LITAFCuratedAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 134Membrane-binding amphipathic helixCuratedAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23WW-binding4

Domaini

The WW-binding motif mediates interaction with NEDD4 and WWOX.By similarity

Sequence similaritiesi

Belongs to the CDIP1/LITAF family.Curated

Phylogenomic databases

eggNOGiENOG410IVVU. Eukaryota.
ENOG41122PJ. LUCA.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039585.
HOVERGENiHBG006272.
InParanoidiP0C0T0.
KOiK19363.
OMAiHCHAEID.
OrthoDBiEOG091G0XNM.
PhylomeDBiP0C0T0.
TreeFamiTF313294.

Family and domain databases

InterProiView protein in InterPro
IPR006629. LITAF.
PfamiView protein in Pfam
PF10601. zf-LITAF-like. 1 hit.
SMARTiView protein in SMART
SM00714. LITAF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPGPYQAA AGPSVMPTAP PTYEETVGVN SYYPTPPAPQ PGPATGLITG
60 70 80 90 100
PDGKGMNPPS YYTQPVPVPN ANAIAVQTVY VQQPISFYDR PIQMCCPSCN
110 120 130 140 150
KMIVTQLSYN AGALTWLSCG SLCLLGCVAG CCFIPFCVDA LQDVDHYCPN
160
CKALLGTYKR L
Length:161
Mass (Da):17,030
Last modified:December 6, 2005 - v1
Checksum:i81DD842A4374F1FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53184 mRNA. No translation available.
RefSeqiNP_001099205.1. NM_001105735.2.
UniGeneiRn.6940.

Genome annotation databases

EnsembliENSRNOT00000003412; ENSRNOP00000003412; ENSRNOG00000002520.
GeneIDi65161.
KEGGirno:65161.
UCSCiRGD:69294. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53184 mRNA. No translation available.
RefSeqiNP_001099205.1. NM_001105735.2.
UniGeneiRn.6940.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003412.

Proteomic databases

PaxDbiP0C0T0.
PRIDEiP0C0T0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003412; ENSRNOP00000003412; ENSRNOG00000002520.
GeneIDi65161.
KEGGirno:65161.
UCSCiRGD:69294. rat.

Organism-specific databases

CTDi9516.
RGDi69294. Litaf.

Phylogenomic databases

eggNOGiENOG410IVVU. Eukaryota.
ENOG41122PJ. LUCA.
GeneTreeiENSGT00540000071542.
HOGENOMiHOG000039585.
HOVERGENiHBG006272.
InParanoidiP0C0T0.
KOiK19363.
OMAiHCHAEID.
OrthoDBiEOG091G0XNM.
PhylomeDBiP0C0T0.
TreeFamiTF313294.

Miscellaneous databases

PROiPR:P0C0T0.

Gene expression databases

BgeeiENSRNOG00000002520.
ExpressionAtlasiP0C0T0. baseline and differential.
GenevisibleiP0C0T0. RN.

Family and domain databases

InterProiView protein in InterPro
IPR006629. LITAF.
PfamiView protein in Pfam
PF10601. zf-LITAF-like. 1 hit.
SMARTiView protein in SMART
SM00714. LITAF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLITAF_RAT
AccessioniPrimary (citable) accession number: P0C0T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.