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P0C0R4 (LIP_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipase
EC=3.1.1.3
Alternative name(s):
Glycerol ester hydrolase
Gene names
Name:lip
Ordered Locus Names:SE_0281
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
   Biological processLipid degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular functiontriglyceride lipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Propeptide36 – 302267Removed in mature form By similarity
PRO_0000042994
Chain303 – 688386Lipase
PRO_0000042995

Sites

Active site4181Charge relay system By similarity
Active site6481Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C0R4 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 6C95DB3A78AF86F6

FASTA68877,343
        10         20         30         40         50         60 
MKTRQNKYSI RKFSVGASSI LIAALLFMGG GSAQAAEQQQ DKGTVENSTT QSIGDGNEKL 

        70         80         90        100        110        120 
SEQQSTQNKN VNEKSNVNSI TENESLHNET PKNEDWIQQQ KDSQNDNKSE SVVEQNKENE 

       130        140        150        160        170        180 
AFVQNHSEEK PQQEQVELEK HASENNQTLH SKAAQSNEDV KTKPSQLDNT AAKQEDSQKE 

       190        200        210        220        230        240 
NLSKQDTQSS KTTDLLRATA QNQSKDSQST EEINKEVNND TQQVTAKNDD AKVESFNLNS 

       250        260        270        280        290        300 
KEEPLKVDKQ ANPTTDKDKS SKNDKGSQDG LANLESNAVA TTNKQSKQQV SEKNEDQTNK 

       310        320        330        340        350        360 
SAKQKQYKNN DPIILVHGFN GFTDDINPSV LTHYWGGDKM NIRQDLEENG YEAYEASISA 

       370        380        390        400        410        420 
FGSNYDRAVE LYYYIKGGRV DYGAAHAAKY GHERYGKTYE GVYKDWKPGQ KIHLVGHSMG 

       430        440        450        460        470        480 
GQTIRQLEEL LRHGNPEEVE YQKQHGGEIS PLYQGGHDNM VSSITTLGTP HNGTHASDLL 

       490        500        510        520        530        540 
GNEAIVRQLA YDVGKMYGNK DSRVDFGLEH WGLKQKPNES YIQYVKRVQN SKLWKSKDSG 

       550        560        570        580        590        600 
LHDLTRDGAT DLNRKTSLNP NIVYKTYTGE STHKTLAGKQ KADLNMFLPF TITGNLIGKA 

       610        620        630        640        650        660 
KEKEWRENDG LVSVISSQHP FNQKYVEATD KNQKGVWQVT PTKHDWDHVD FVGQDSTDTK 

       670        680 
RTRDELQQFW HGLAEDLVQS EQLTSTNK

« Hide

References

[1]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015929 Genomic DNA. Translation: AAO03878.1.
RefSeqNP_763836.1. NC_004461.1.

3D structure databases

ProteinModelPortalP0C0R4.
SMRP0C0R4. Positions 307-686.
ModBaseSearch...

Protein-protein interaction databases

STRINGP0C0R4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000041051; EBSTAP00000039684; EBSTAG00000041049.
GeneID1058073.
GenomeReviewsGene locus SE_0281 in contig AE015929_GR.
KEGGsep:SE0281.
PATRIC19606357. VBIStaEpi113981_0257.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1075.
GeneTreeEBGT00050000023709.
HOGENOMHBG694146.
OMAYTGESTH.
ProtClustDBCLSK2752181.

Enzyme and pathway databases

BioCycSEPI176280:SE_0281-MONOMER.

Family and domain databases

InterProIPR005877. Gpos_YSIRK.
[Graphical view]
KOK01046.
PfamPF04650. YSIRK_signal. 1 hit.
[Graphical view]
TIGRFAMsTIGR01168. YSIRK_signal. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLIP_STAES
AccessionPrimary (citable) accession number: P0C0R4
Secondary accession number(s): Q02510
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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