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Reviewed, UniProtKB/Swiss-Prot P0C0Q9 (GYRA_STAEP)

Last modified June 16, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA gyrase subunit A
    EC=5.99.1.3
Gene names
Name: gyrA
OrganismStaphylococcus epidermidis
Taxonomic identifier1282 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length94 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer.

Sequence similarities

Belongs to the topoisomerase gyrA/parC subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›94›94DNA gyrase subunit A
PRO_0000145258

Experimental info

Mutagenesis841S → F: Resistant to ciprofloxacin. Ref.1
Non-terminal residue941

Sequences

Sequence LengthMass (Da)Tools
P0C0Q9-1 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 72862CF17C045728

FASTA9410,723
        10         20         30         40         50         60 
MAELPQSRIN ERNITSEMRE SFLDYAMSVI VSRALPDVRD GLKPVHRRIL YGLNEQGMTP 

        70         80         90 
DKPYKKSARI VGDVMGKYHP HGDSSIYEAM VRMA 

« Hide

References

[1]"Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis."
Sreedharan S., Peterson L.R., Fisher L.M.
Antimicrob. Agents Chemother. 35:2151-2154(1991) [PubMed: 1662027] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF SER-84.

Cross-references

Sequence databases

S72603 Genomic DNA. Translation: AAB20672.1.
PIRA49832.

3D structure databases

HSSPHSSP built from PDB template 1AB4 based on UniProtKB P09097.
SMRP0C0Q9. Positions 31-94.
ModBaseSearch...

Enzyme and pathway databases

BRENDA5.99.1.3. 874.

Family and domain databases

InterProIPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
PfamPF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
ProDomPD000742. DNA_topoisoIV. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameGYRA_STAEP
AccessionPrimary (citable) accession number: P0C0Q9
Secondary accession number(s): P54112
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents