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P0C0Q6

- SODM_STAES

UniProt

P0C0Q6 - SODM_STAES

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Protein
Superoxide dismutase [Mn/Fe]
Gene
sodA, SE_1240
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Binds 1 manganese or iron ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese or iron By similarity
Metal bindingi81 – 811Manganese or iron By similarity
Metal bindingi161 – 1611Manganese or iron By similarity
Metal bindingi165 – 1651Manganese or iron By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Iron, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:SE_1240
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Superoxide dismutase [Mn/Fe]
PRO_0000160077Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi176280.SE1240.

Structurei

3D structure databases

ProteinModelPortaliP0C0Q6.
SMRiP0C0Q6. Positions 2-196.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiTIFWQIM.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0Q6-1 [UniParc]FASTAAdd to Basket

« Hide

MAFELPNLPY AYDALEPHID KQTMEIHHDK HHNTYVTKLN SAVEGTDLEA    50
KSIEEIVANL DSVPSNIQTA VRNNGGGHLN HSLFWELLSP NSEEKGEVVD 100
KIKEQWGSLD EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPI 150
TEGKTPILGL DVWEHAYYLK YQNKRPDYIN AFWNVVNWEK VNELYNATK 199
Length:199
Mass (Da):22,722
Last modified:November 22, 2005 - v1
Checksum:iE25419284F3378DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1.
AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeqiNP_764795.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04839; AAO04839; SE_1240.
GeneIDi1057028.
KEGGisep:SE1240.
PATRICi19608270. VBIStaEpi113981_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1 .
AE015929 Genomic DNA. Translation: AAO04839.1 .
RefSeqi NP_764795.1. NC_004461.1.

3D structure databases

ProteinModelPortali P0C0Q6.
SMRi P0C0Q6. Positions 2-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04839 ; AAO04839 ; SE_1240 .
GeneIDi 1057028.
KEGGi sep:SE1240.
PATRICi 19608270. VBIStaEpi113981_1208.

Phylogenomic databases

eggNOGi COG0605.
KOi K04564.
OMAi TIFWQIM.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1246-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci."
    Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E.
    J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYMATIC ACTIVITY, SUBUNIT.
  2. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiSODM_STAES
AccessioniPrimary (citable) accession number: P0C0Q6
Secondary accession number(s): P0C0Q5, Q93CF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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