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P0C0Q6 (SODM_STAES) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Mn/Fe]

EC=1.15.1.1
Gene names
Name:sodA
Ordered Locus Names:SE_1240
OrganismStaphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]
Taxonomic identifier176280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2. Ref.1

Cofactor

Binds 1 manganese or iron ion per subunit By similarity.

Subunit structure

Homodimer. Ref.1

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
   Biological processStress response
   LigandIron
Manganese
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Superoxide dismutase [Mn/Fe]
PRO_0000160077

Sites

Metal binding271Manganese or iron By similarity
Metal binding811Manganese or iron By similarity
Metal binding1611Manganese or iron By similarity
Metal binding1651Manganese or iron By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C0Q6 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: E25419284F3378DD

FASTA19922,722
        10         20         30         40         50         60 
MAFELPNLPY AYDALEPHID KQTMEIHHDK HHNTYVTKLN SAVEGTDLEA KSIEEIVANL 

        70         80         90        100        110        120 
DSVPSNIQTA VRNNGGGHLN HSLFWELLSP NSEEKGEVVD KIKEQWGSLD EFKKEFADKA 

       130        140        150        160        170        180 
AARFGSGWAW LVVNNGQLEI VTTPNQDNPI TEGKTPILGL DVWEHAYYLK YQNKRPDYIN 

       190 
AFWNVVNWEK VNELYNATK 

« Hide

References

« Hide 'large scale' references
[1]"The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci."
Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E.
J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYMATIC ACTIVITY, SUBUNIT.
[2]"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF410177 Genomic DNA. Translation: AAL09677.1.
AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeqNP_764795.1. NC_004461.1.

3D structure databases

ProteinModelPortalP0C0Q6.
SMRP0C0Q6. Positions 2-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176280.SE1240.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO04839; AAO04839; SE_1240.
GeneID1057028.
KEGGsep:SE1240.
PATRIC19608270. VBIStaEpi113981_1208.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0605.
KOK04564.
OMADYISAFW.
OrthoDBEOG63NMNT.
ProtClustDBCLSK884424.

Enzyme and pathway databases

BioCycSEPI176280:GCDG-1246-MONOMER.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODM_STAES
AccessionPrimary (citable) accession number: P0C0Q6
Secondary accession number(s): P0C0Q5, Q93CF4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 13, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families