P0C0Q6 (SODM_STAES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn/Fe]
EC=1.15.1.1

Gene names

Name:	sodA
Ordered Locus Names:	SE_1240

Organism

Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP]

Taxonomic identifier

176280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2. Ref.1
Cofactor	Binds 1 manganese or iron ion per subunit By similarity.
Subunit structure	Homodimer. Ref.1
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Biological process	Stress response
Ligand	Iron Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Superoxide dismutase [Mn/Fe]		PRO_0000160077
Sites
	Metal binding	27	1	Manganese or iron By similarity
	Metal binding	81	1	Manganese or iron By similarity
	Metal binding	161	1	Manganese or iron By similarity
	Metal binding	165	1	Manganese or iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C0Q6 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: E25419284F3378DD	FASTA	199	22,722
	10 20 30 40 50 60 MAFELPNLPY AYDALEPHID KQTMEIHHDK HHNTYVTKLN SAVEGTDLEA KSIEEIVANL 70 80 90 100 110 120 DSVPSNIQTA VRNNGGGHLN HSLFWELLSP NSEEKGEVVD KIKEQWGSLD EFKKEFADKA 130 140 150 160 170 180 AARFGSGWAW LVVNNGQLEI VTTPNQDNPI TEGKTPILGL DVWEHAYYLK YQNKRPDYIN 190 AFWNVVNWEK VNELYNATK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci." Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E. J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYMATIC ACTIVITY, SUBUNIT.
[2]	"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 12228.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF410177 Genomic DNA. Translation: AAL09677.1. AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeq	NP_764795.1. NC_004461.1.
3D structure databases
ProteinModelPortal	P0C0Q6.
SMR	P0C0Q6. Positions 2-196.
ModBase	Search...
Protein-protein interaction databases
STRING	176280.SE1240.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO04839; AAO04839; SE_1240.
GeneID	1057028.
KEGG	sep:SE1240.
PATRIC	19608270. VBIStaEpi113981_1208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0605.
KO	K04564.
OMA	ETMTIHH.
ProtClustDB	CLSK884424.
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM_STAES

Accession

Primary (citable) accession number: P0C0Q6
Secondary accession number(s): P0C0Q5, Q93CF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program