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P0C0Q6

- SODM_STAES

UniProt

P0C0Q6 - SODM_STAES

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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Binds 1 manganese or iron ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese or ironBy similarity
Metal bindingi81 – 811Manganese or ironBy similarity
Metal bindingi161 – 1611Manganese or ironBy similarity
Metal bindingi165 – 1651Manganese or ironBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

Iron, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSEPI176280:GCDG-1246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:SE_1240
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Superoxide dismutase [Mn/Fe]PRO_0000160077Add
BLAST

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi176280.SE1240.

Structurei

3D structure databases

ProteinModelPortaliP0C0Q6.
SMRiP0C0Q6. Positions 2-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiTIFWQIM.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFELPNLPY AYDALEPHID KQTMEIHHDK HHNTYVTKLN SAVEGTDLEA
60 70 80 90 100
KSIEEIVANL DSVPSNIQTA VRNNGGGHLN HSLFWELLSP NSEEKGEVVD
110 120 130 140 150
KIKEQWGSLD EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPI
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIN AFWNVVNWEK VNELYNATK
Length:199
Mass (Da):22,722
Last modified:November 22, 2005 - v1
Checksum:iE25419284F3378DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1.
AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeqiNP_764795.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04839; AAO04839; SE_1240.
GeneIDi1057028.
KEGGisep:SE1240.
PATRICi19608270. VBIStaEpi113981_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1 .
AE015929 Genomic DNA. Translation: AAO04839.1 .
RefSeqi NP_764795.1. NC_004461.1.

3D structure databases

ProteinModelPortali P0C0Q6.
SMRi P0C0Q6. Positions 2-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176280.SE1240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO04839 ; AAO04839 ; SE_1240 .
GeneIDi 1057028.
KEGGi sep:SE1240.
PATRICi 19608270. VBIStaEpi113981_1208.

Phylogenomic databases

eggNOGi COG0605.
KOi K04564.
OMAi TIFWQIM.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci SEPI176280:GCDG-1246-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The superoxide dismutase gene sodM is unique to Staphylococcus aureus: absence of sodM in coagulase-negative staphylococci."
    Wright Valderas M., Gatson J.W., Wreyford N., Hart M.E.
    J. Bacteriol. 184:2465-2472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ENZYMATIC ACTIVITY, SUBUNIT.
  2. "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)."
    Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.
    Mol. Microbiol. 49:1577-1593(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 12228.

Entry informationi

Entry nameiSODM_STAES
AccessioniPrimary (citable) accession number: P0C0Q6
Secondary accession number(s): P0C0Q5, Q93CF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3