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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodA

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Mn2+By similarity, Fe2+By similarityNote: Binds 1 Mn2+ or Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or ironBy similarity1
Metal bindingi81Manganese or ironBy similarity1
Metal bindingi161Manganese or ironBy similarity1
Metal bindingi165Manganese or ironBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processStress response
LigandIron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodA
Ordered Locus Names:SE_1240
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001600771 – 199Superoxide dismutase [Mn/Fe]Add BLAST199

Proteomic databases

PRIDEiP0C0Q6.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi176280.SE1240.

Structurei

3D structure databases

ProteinModelPortaliP0C0Q6.
SMRiP0C0Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.
OMAiINQGGGH.

Family and domain databases

InterProiView protein in InterPro
IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
PfamiView protein in Pfam
PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiView protein in PROSITE
PS00088. SOD_MN. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFELPNLPY AYDALEPHID KQTMEIHHDK HHNTYVTKLN SAVEGTDLEA
60 70 80 90 100
KSIEEIVANL DSVPSNIQTA VRNNGGGHLN HSLFWELLSP NSEEKGEVVD
110 120 130 140 150
KIKEQWGSLD EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPI
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIN AFWNVVNWEK VNELYNATK
Length:199
Mass (Da):22,722
Last modified:November 22, 2005 - v1
Checksum:iE25419284F3378DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1.
AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeqiNP_764795.1. NC_004461.1.
WP_001831217.1. NC_004461.1.

Genome annotation databases

EnsemblBacteriaiAAO04839; AAO04839; SE_1240.
GeneIDi1057028.
KEGGisep:SE1240.
PATRICi19608270. VBIStaEpi113981_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410177 Genomic DNA. Translation: AAL09677.1.
AE015929 Genomic DNA. Translation: AAO04839.1.
RefSeqiNP_764795.1. NC_004461.1.
WP_001831217.1. NC_004461.1.

3D structure databases

ProteinModelPortaliP0C0Q6.
SMRiP0C0Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176280.SE1240.

Proteomic databases

PRIDEiP0C0Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO04839; AAO04839; SE_1240.
GeneIDi1057028.
KEGGisep:SE1240.
PATRICi19608270. VBIStaEpi113981_1208.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
KOiK04564.
OMAiINQGGGH.

Family and domain databases

InterProiView protein in InterPro
IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
PfamiView protein in Pfam
PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiView protein in PROSITE
PS00088. SOD_MN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_STAES
AccessioniPrimary (citable) accession number: P0C0Q6
Secondary accession number(s): P0C0Q5, Q93CF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 15, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.