Reviewed,
UniProtKB/Swiss-Prot P0C0Q2 (GSEA_STAES)
Last modified
June 16, 2009.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutamyl endopeptidase EC=3.4.21.19 Alternative name(s): Glutamic acid-specific protease Short name=GluSE | ||||||
| Gene names |
| ||||||
| Organism | Staphylococcus epidermidis (strain ATCC 12228) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 176280 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 282 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Exhibits a significant hydrolytic activity for the carbonyl side of glutamic acid. Shows activity toward human fibronectin and type 1 collagen By similarity. |
| Catalytic activity | Preferential cleavage: Glu-|-Xaa, Asp-|-Xaa. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Secreted By similarity. |
| Sequence similarities | Belongs to the peptidase S1B family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Virulence |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hydrolase Protease Serine protease |
| PTM | Zymogen |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW proteolysisInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Potential | ||||||
| Propeptide | 28 – 66 | 39 | By similarity | PRO_0000042921 | |||||
| Chain | 67 – 282 | 216 | Glutamyl endopeptidase | PRO_0000042922 | |||||
Sites | |||||||||
| Active site | 117 | 1 | Charge relay system By similarity | ||||||
| Active site | 159 | 1 | Charge relay system By similarity | ||||||
| Active site | 235 | 1 | Charge relay system By similarity | ||||||
Sequences
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References
| [1] | "Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228)." Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M. Mol. Microbiol. 49:1577-1593(2003) [PubMed: 12950922] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AE015929 Genomic DNA. Translation: AAO05142.1. | |
| RefSeq | NP_765098.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DT2 based on UniProtKB P09332. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | S01.269. |
Genome annotation databases | |
| GeneID | 1055780. |
| GenomeReviews | Gene locus SE_1543 in contig AE015929_GR. |
| KEGG | sep:SE1543. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0C0Q2. |
| OMA | P0C0Q2. EDINFAN. |
Enzyme and pathway databases | |
| BioCyc | SEPI176280:SE_1543-MON. |
Family and domain databases | |
| InterPro | IPR000126. Pept_S1B_AS. IPR001254. Peptidase_S1_S6. IPR008256. Peptidase_S1B. IPR008353. Peptidase_S1B_tx. [Graphical view] |
| Pfam | PF00089. Trypsin. 1 hit. [Graphical view] |
| PRINTS | PR01774. EXFOLTOXIN. PR00839. V8PROTEASE. |
| PROSITE | PS00672. V8_HIS. False negative. PS00673. V8_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GSEA_STAES | ||||||||
| Accession | Primary (citable) accession number: P0C0Q2 Secondary accession number(s): Q7DG19, Q8CMC1, Q9AJX0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


