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P0C0P8 (NPS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide S
Gene names
Name:Nps
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. Ref.2

Subcellular location

Secreted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 6946
PRO_0000042941
Peptide70 – 8920Neuropeptide S
PRO_0000042942

Sequences

Sequence LengthMass (Da)Tools
P0C0P8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: A2C8208D20107D59

FASTA899,861
        10         20         30         40         50         60 
MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE GSDRLAFLKP 

        70         80 
ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ 

« Hide

References

[1]"Novel G protein-coupled receptor protein and its DNA."
Sato S., Shintani Y., Miyajima N., Yoshimura K.
Patent number WO0231145, 18-APR-2002
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Neuropeptide S as a novel arousal promoting peptide transmitter."
Reinscheid R.K., Xu Y.L.
FEBS J. 272:5689-5693(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BD168690 Unassigned DNA. No translation available.
CCDSCCDS52420.1.
RefSeqNP_001157083.1. NM_001163611.1.
UniGeneMm.192092.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000095597.

PTM databases

PhosphoSiteP0C0P8.

Proteomic databases

PRIDEP0C0P8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
GeneID100043254.
KEGGmmu:100043254.
UCSCuc012fvj.1. mouse.

Organism-specific databases

CTD594857.
MGIMGI:3642232. Nps.

Phylogenomic databases

eggNOGNOG113114.
GeneTreeENSGT00400000024769.
HOGENOMHOG000113845.
HOVERGENHBG082056.
InParanoidP0C0P8.
OMALSTMHVF.
OrthoDBEOG7ZD1Z5.
PhylomeDBP0C0P8.

Gene expression databases

BgeeP0C0P8.
CleanExMM_NPS.
GenevestigatorP0C0P8.

Family and domain databases

InterProIPR028138. Neuropeptide_S.
[Graphical view]
PfamPF14993. Neuropeptide_S. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio455855.
PROP0C0P8.
SOURCESearch...

Entry information

Entry nameNPS_MOUSE
AccessionPrimary (citable) accession number: P0C0P8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot