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Protein

Neuropeptide S

Gene

Nps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.1 Publication

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. positive regulation of action potential Source: MGI
  3. positive regulation of synaptic transmission, GABAergic Source: MGI
  4. positive regulation of synaptic transmission, glutamatergic Source: MGI
  5. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:Nps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:3642232. Nps.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 6946PRO_0000042941Add
BLAST
Peptidei70 – 8920Neuropeptide SPRO_0000042942Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PRIDEiP0C0P8.

PTM databases

PhosphoSiteiP0C0P8.

Expressioni

Gene expression databases

BgeeiP0C0P8.
CleanExiMM_NPS.
GenevestigatoriP0C0P8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113114.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P8.
OMAiFMKRSFR.
OrthoDBiEOG7ZD1Z5.
PhylomeDBiP0C0P8.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0P8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE
60 70 80
GSDRLAFLKP ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ
Length:89
Mass (Da):9,861
Last modified:November 22, 2005 - v1
Checksum:iA2C8208D20107D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA. No translation available.
CCDSiCCDS52420.1.
RefSeqiNP_001157083.1. NM_001163611.1.
UniGeneiMm.192092.

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
GeneIDi100043254.
KEGGimmu:100043254.
UCSCiuc012fvj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA. No translation available.
CCDSiCCDS52420.1.
RefSeqiNP_001157083.1. NM_001163611.1.
UniGeneiMm.192092.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597.

PTM databases

PhosphoSiteiP0C0P8.

Proteomic databases

PRIDEiP0C0P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
GeneIDi100043254.
KEGGimmu:100043254.
UCSCiuc012fvj.1. mouse.

Organism-specific databases

CTDi594857.
MGIiMGI:3642232. Nps.

Phylogenomic databases

eggNOGiNOG113114.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P8.
OMAiFMKRSFR.
OrthoDBiEOG7ZD1Z5.
PhylomeDBiP0C0P8.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

NextBioi455855.
PROiP0C0P8.
SOURCEiSearch...

Gene expression databases

BgeeiP0C0P8.
CleanExiMM_NPS.
GenevestigatoriP0C0P8.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel G protein-coupled receptor protein and its DNA."
    Sato S., Shintani Y., Miyajima N., Yoshimura K.
    Patent number WO0231145, 18-APR-2002
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Neuropeptide S as a novel arousal promoting peptide transmitter."
    Reinscheid R.K., Xu Y.L.
    FEBS J. 272:5689-5693(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPS_MOUSE
AccessioniPrimary (citable) accession number: P0C0P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.