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P0C0P8

- NPS_MOUSE

UniProt

P0C0P8 - NPS_MOUSE

Protein

Neuropeptide S

Gene

Nps

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.1 Publication

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. positive regulation of action potential Source: MGI
    3. positive regulation of synaptic transmission, GABAergic Source: MGI
    4. positive regulation of synaptic transmission, glutamatergic Source: MGI
    5. visual learning Source: MGI

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide S
    Gene namesi
    Name:Nps
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:3642232. Nps.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 6946PRO_0000042941Add
    BLAST
    Peptidei70 – 8920Neuropeptide SPRO_0000042942Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiP0C0P8.

    PTM databases

    PhosphoSiteiP0C0P8.

    Expressioni

    Gene expression databases

    BgeeiP0C0P8.
    CleanExiMM_NPS.
    GenevestigatoriP0C0P8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000095597.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113114.
    GeneTreeiENSGT00400000024769.
    HOGENOMiHOG000113845.
    HOVERGENiHBG082056.
    InParanoidiP0C0P8.
    OMAiLSTMHVF.
    OrthoDBiEOG7ZD1Z5.
    PhylomeDBiP0C0P8.

    Family and domain databases

    InterProiIPR028138. Neuropeptide_S.
    [Graphical view]
    PfamiPF14993. Neuropeptide_S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C0P8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE   50
    GSDRLAFLKP ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ 89
    Length:89
    Mass (Da):9,861
    Last modified:November 22, 2005 - v1
    Checksum:iA2C8208D20107D59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BD168690 Unassigned DNA. No translation available.
    CCDSiCCDS52420.1.
    RefSeqiNP_001157083.1. NM_001163611.1.
    UniGeneiMm.192092.

    Genome annotation databases

    EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
    GeneIDi100043254.
    KEGGimmu:100043254.
    UCSCiuc012fvj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BD168690 Unassigned DNA. No translation available.
    CCDSi CCDS52420.1.
    RefSeqi NP_001157083.1. NM_001163611.1.
    UniGenei Mm.192092.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000095597.

    PTM databases

    PhosphoSitei P0C0P8.

    Proteomic databases

    PRIDEi P0C0P8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097983 ; ENSMUSP00000095597 ; ENSMUSG00000073804 .
    GeneIDi 100043254.
    KEGGi mmu:100043254.
    UCSCi uc012fvj.1. mouse.

    Organism-specific databases

    CTDi 594857.
    MGIi MGI:3642232. Nps.

    Phylogenomic databases

    eggNOGi NOG113114.
    GeneTreei ENSGT00400000024769.
    HOGENOMi HOG000113845.
    HOVERGENi HBG082056.
    InParanoidi P0C0P8.
    OMAi LSTMHVF.
    OrthoDBi EOG7ZD1Z5.
    PhylomeDBi P0C0P8.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 455855.
    PROi P0C0P8.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0C0P8.
    CleanExi MM_NPS.
    Genevestigatori P0C0P8.

    Family and domain databases

    InterProi IPR028138. Neuropeptide_S.
    [Graphical view ]
    Pfami PF14993. Neuropeptide_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel G protein-coupled receptor protein and its DNA."
      Sato S., Shintani Y., Miyajima N., Yoshimura K.
      Patent number WO0231145, 18-APR-2002
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Neuropeptide S as a novel arousal promoting peptide transmitter."
      Reinscheid R.K., Xu Y.L.
      FEBS J. 272:5689-5693(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNPS_MOUSE
    AccessioniPrimary (citable) accession number: P0C0P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3