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Protein

Neuropeptide S

Gene

Nps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.1 Publication

GO - Biological processi

  • neuropeptide signaling pathway Source: UniProtKB-KW
  • positive regulation of action potential Source: MGI
  • positive regulation of circadian sleep/wake cycle, wakefulness Source: Ensembl
  • positive regulation of synaptic transmission, GABAergic Source: MGI
  • positive regulation of synaptic transmission, glutamatergic Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:Nps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3642232. Nps.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000004294124 – 69Add BLAST46
PeptideiPRO_000004294270 – 89Neuropeptide SAdd BLAST20

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP0C0P8.
PRIDEiP0C0P8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000073804.
CleanExiMM_NPS.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597.

Structurei

3D structure databases

ProteinModelPortaliP0C0P8.
SMRiP0C0P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J45R. Eukaryota.
ENOG41115PF. LUCA.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P8.
OMAiMKRSFRN.
OrthoDBiEOG091G14R3.
PhylomeDBiP0C0P8.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE
60 70 80
GSDRLAFLKP ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ
Length:89
Mass (Da):9,861
Last modified:November 22, 2005 - v1
Checksum:iA2C8208D20107D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA. No translation available.
CCDSiCCDS52420.1.
RefSeqiNP_001157083.1. NM_001163611.1.
UniGeneiMm.192092.

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
GeneIDi100043254.
KEGGimmu:100043254.
UCSCiuc012fvj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168690 Unassigned DNA. No translation available.
CCDSiCCDS52420.1.
RefSeqiNP_001157083.1. NM_001163611.1.
UniGeneiMm.192092.

3D structure databases

ProteinModelPortaliP0C0P8.
SMRiP0C0P8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095597.

Proteomic databases

PaxDbiP0C0P8.
PRIDEiP0C0P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
GeneIDi100043254.
KEGGimmu:100043254.
UCSCiuc012fvj.1. mouse.

Organism-specific databases

CTDi594857.
MGIiMGI:3642232. Nps.

Phylogenomic databases

eggNOGiENOG410J45R. Eukaryota.
ENOG41115PF. LUCA.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P8.
OMAiMKRSFRN.
OrthoDBiEOG091G14R3.
PhylomeDBiP0C0P8.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP0C0P8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073804.
CleanExiMM_NPS.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPS_MOUSE
AccessioniPrimary (citable) accession number: P0C0P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.