ID   NPS_HUMAN               Reviewed;          89 AA.
AC   P0C0P6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   24-JAN-2024, entry version 108.
DE   RecName: Full=Neuropeptide S;
DE   Flags: Precursor;
GN   Name=NPS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sato S., Shintani Y., Miyajima N., Yoshimura K.;
RT   "Novel G protein-coupled receptor protein and its DNA.";
RL   Patent number WO0231145, 18-APR-2002.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=15312648; DOI=10.1016/j.neuron.2004.08.005;
RA   Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z.,
RA   Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L.,
RA   Civelli O.;
RT   "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like
RT   effects.";
RL   Neuron 43:487-497(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=16790440; DOI=10.1074/jbc.m603691200;
RA   Bernier V., Stocco R., Bogusky M.J., Joyce J.G., Parachoniak C.,
RA   Grenier K., Arget M., Mathieu M.C., O'Neill G.P., Slipetz D.,
RA   Crackower M.A., Tan C.M., Therien A.G.;
RT   "Structure-function relationships in the neuropeptide S receptor: molecular
RT   consequences of the asthma-associated mutation N107I.";
RL   J. Biol. Chem. 281:24704-24712(2006).
CC   -!- FUNCTION: Modulates arousal and anxiety. May play an important
CC       anorexigenic role (By similarity). Binds to its receptor NPSR1 with
CC       nanomolar affinity to increase intracellular calcium concentrations
CC       (PubMed:15312648, PubMed:16790440). {ECO:0000250,
CC       ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:16790440}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; BD168686; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL355316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC148465; AAI48466.1; -; mRNA.
DR   EMBL; BC156665; AAI56666.1; -; mRNA.
DR   CCDS; CCDS41577.1; -.
DR   RefSeq; NP_001025184.1; NM_001030013.1.
DR   AlphaFoldDB; P0C0P6; -.
DR   IntAct; P0C0P6; 1.
DR   STRING; 9606.ENSP00000381105; -.
DR   ChEMBL; CHEMBL3596086; -.
DR   BioMuta; NPS; -.
DR   PaxDb; 9606-ENSP00000381105; -.
DR   PeptideAtlas; P0C0P6; -.
DR   Antibodypedia; 57702; 152 antibodies from 19 providers.
DR   DNASU; 594857; -.
DR   Ensembl; ENST00000398023.3; ENSP00000381105.2; ENSG00000214285.3.
DR   GeneID; 594857; -.
DR   KEGG; hsa:594857; -.
DR   MANE-Select; ENST00000398023.3; ENSP00000381105.2; NM_001030013.2; NP_001025184.1.
DR   UCSC; uc001ljx.2; human.
DR   AGR; HGNC:33940; -.
DR   CTD; 594857; -.
DR   DisGeNET; 594857; -.
DR   GeneCards; NPS; -.
DR   HGNC; HGNC:33940; NPS.
DR   HPA; ENSG00000214285; Not detected.
DR   MIM; 609513; gene.
DR   neXtProt; NX_P0C0P6; -.
DR   OpenTargets; ENSG00000214285; -.
DR   PharmGKB; PA162398160; -.
DR   VEuPathDB; HostDB:ENSG00000214285; -.
DR   eggNOG; ENOG502SSTA; Eukaryota.
DR   GeneTree; ENSGT00400000024769; -.
DR   HOGENOM; CLU_2432613_0_0_1; -.
DR   InParanoid; P0C0P6; -.
DR   OMA; MFVCSGY; -.
DR   OrthoDB; 5313408at2759; -.
DR   PhylomeDB; P0C0P6; -.
DR   PathwayCommons; P0C0P6; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-416476; G alpha (q) signalling events.
DR   Reactome; R-HSA-418555; G alpha (s) signalling events.
DR   SignaLink; P0C0P6; -.
DR   BioGRID-ORCS; 594857; 11 hits in 1067 CRISPR screens.
DR   GeneWiki; Neuropeptide_S; -.
DR   GenomeRNAi; 594857; -.
DR   Pharos; P0C0P6; Tbio.
DR   PRO; PR:P0C0P6; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; P0C0P6; Protein.
DR   Bgee; ENSG00000214285; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 6 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045760; P:positive regulation of action potential; IBA:GO_Central.
DR   GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; IEA:Ensembl.
DR   GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IBA:GO_Central.
DR   GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR   InterPro; IPR028138; Neuropeptide_S.
DR   PANTHER; PTHR36679; NEUROPEPTIDE S; 1.
DR   PANTHER; PTHR36679:SF1; NEUROPEPTIDE S; 1.
DR   Pfam; PF14993; Neuropeptide_S; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..67
FT                   /id="PRO_0000042888"
FT   PEPTIDE         70..89
FT                   /note="Neuropeptide S"
FT                   /id="PRO_0000042889"
FT   VARIANT         14
FT                   /note="S -> L (in dbSNP:rs990310)"
FT                   /id="VAR_051239"
FT   VARIANT         75
FT                   /note="V -> L (in dbSNP:rs4751440)"
FT                   /id="VAR_051240"
SQ   SEQUENCE   89 AA;  10103 MW;  41574555F540A7A4 CRC64;
     MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD RSKELAFLKP
     ILEKMFVKRS FRNGVGTGMK KTSFQRAKS
//