Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C0P6

- NPS_HUMAN

UniProt

P0C0P6 - NPS_HUMAN

Protein

Neuropeptide S

Gene

NPS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations By similarity.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. positive regulation of action potential Source: Ensembl
    3. positive regulation of synaptic transmission, GABAergic Source: Ensembl
    4. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
    5. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide S
    Gene namesi
    Name:NPS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:33940. NPS.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162398160.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 6744PRO_0000042888Add
    BLAST
    Peptidei70 – 8920Neuropeptide SPRO_0000042889Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP0C0P6.
    PRIDEiP0C0P6.

    Expressioni

    Gene expression databases

    CleanExiHS_NPS.
    GenevestigatoriP0C0P6.

    Organism-specific databases

    HPAiCAB020139.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381105.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0P6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113114.
    HOGENOMiHOG000113845.
    HOVERGENiHBG082056.
    InParanoidiP0C0P6.
    OMAiLSTMHVF.
    OrthoDBiEOG7ZD1Z5.
    PhylomeDBiP0C0P6.

    Family and domain databases

    InterProiIPR028138. Neuropeptide_S.
    [Graphical view]
    PfamiPF14993. Neuropeptide_S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C0P6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD   50
    RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS 89
    Length:89
    Mass (Da):10,103
    Last modified:November 22, 2005 - v1
    Checksum:i41574555F540A7A4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141S → L.
    Corresponds to variant rs990310 [ dbSNP | Ensembl ].
    VAR_051239
    Natural varianti75 – 751V → L.
    Corresponds to variant rs4751440 [ dbSNP | Ensembl ].
    VAR_051240

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BD168686 mRNA. No translation available.
    AL355316 Genomic DNA. No translation available.
    BC148465 mRNA. Translation: AAI48466.1.
    BC156665 mRNA. Translation: AAI56666.1.
    CCDSiCCDS41577.1.
    RefSeqiNP_001025184.1. NM_001030013.1.
    UniGeneiHs.643423.

    Genome annotation databases

    EnsembliENST00000398023; ENSP00000381105; ENSG00000214285.
    GeneIDi594857.
    KEGGihsa:594857.
    UCSCiuc001ljx.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BD168686 mRNA. No translation available.
    AL355316 Genomic DNA. No translation available.
    BC148465 mRNA. Translation: AAI48466.1 .
    BC156665 mRNA. Translation: AAI56666.1 .
    CCDSi CCDS41577.1.
    RefSeqi NP_001025184.1. NM_001030013.1.
    UniGenei Hs.643423.

    3D structure databases

    ProteinModelPortali P0C0P6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381105.

    Proteomic databases

    PaxDbi P0C0P6.
    PRIDEi P0C0P6.

    Protocols and materials databases

    DNASUi 594857.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398023 ; ENSP00000381105 ; ENSG00000214285 .
    GeneIDi 594857.
    KEGGi hsa:594857.
    UCSCi uc001ljx.1. human.

    Organism-specific databases

    CTDi 594857.
    GeneCardsi GC10P129347.
    HGNCi HGNC:33940. NPS.
    HPAi CAB020139.
    MIMi 609513. gene.
    neXtProti NX_P0C0P6.
    PharmGKBi PA162398160.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG113114.
    HOGENOMi HOG000113845.
    HOVERGENi HBG082056.
    InParanoidi P0C0P6.
    OMAi LSTMHVF.
    OrthoDBi EOG7ZD1Z5.
    PhylomeDBi P0C0P6.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Neuropeptide_S.
    NextBioi 112779.
    PROi P0C0P6.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_NPS.
    Genevestigatori P0C0P6.

    Family and domain databases

    InterProi IPR028138. Neuropeptide_S.
    [Graphical view ]
    Pfami PF14993. Neuropeptide_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel G protein-coupled receptor protein and its DNA."
      Sato S., Shintani Y., Miyajima N., Yoshimura K.
      Patent number WO0231145, 18-APR-2002
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. Cited for: RECEPTOR IDENTIFICATION.

    Entry informationi

    Entry nameiNPS_HUMAN
    AccessioniPrimary (citable) accession number: P0C0P6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3