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P0C0P6 (NPS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide S
Gene names
Name:NPS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations By similarity.

Subcellular location

Secreted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 6744
PRO_0000042888
Peptide70 – 8920Neuropeptide S
PRO_0000042889

Natural variations

Natural variant141S → L.
Corresponds to variant rs990310 [ dbSNP | Ensembl ].
VAR_051239
Natural variant751V → L.
Corresponds to variant rs4751440 [ dbSNP | Ensembl ].
VAR_051240

Sequences

Sequence LengthMass (Da)Tools
P0C0P6 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 41574555F540A7A4

FASTA8910,103
        10         20         30         40         50         60 
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD RSKELAFLKP 

        70         80 
ILEKMFVKRS FRNGVGTGMK KTSFQRAKS 

« Hide

References

« Hide 'large scale' references
[1]"Novel G protein-coupled receptor protein and its DNA."
Sato S., Shintani Y., Miyajima N., Yoshimura K.
Patent number WO0231145, 18-APR-2002
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects."
Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z., Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L., Civelli O.
Neuron 43:487-497(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: RECEPTOR IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BD168686 mRNA. No translation available.
AL355316 Genomic DNA. No translation available.
BC148465 mRNA. Translation: AAI48466.1.
BC156665 mRNA. Translation: AAI56666.1.
CCDSCCDS41577.1.
RefSeqNP_001025184.1. NM_001030013.1.
UniGeneHs.643423.

3D structure databases

ProteinModelPortalP0C0P6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000381105.

Proteomic databases

PaxDbP0C0P6.
PRIDEP0C0P6.

Protocols and materials databases

DNASU594857.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398023; ENSP00000381105; ENSG00000214285.
GeneID594857.
KEGGhsa:594857.
UCSCuc001ljx.1. human.

Organism-specific databases

CTD594857.
GeneCardsGC10P129347.
HGNCHGNC:33940. NPS.
HPACAB020139.
MIM609513. gene.
neXtProtNX_P0C0P6.
PharmGKBPA162398160.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG113114.
HOGENOMHOG000113845.
HOVERGENHBG082056.
InParanoidP0C0P6.
OMALSTMHVF.
OrthoDBEOG7ZD1Z5.
PhylomeDBP0C0P6.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_NPS.
GenevestigatorP0C0P6.

Family and domain databases

InterProIPR028138. Neuropeptide_S.
[Graphical view]
PfamPF14993. Neuropeptide_S. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuropeptide_S.
NextBio112779.
PROP0C0P6.
SOURCESearch...

Entry information

Entry nameNPS_HUMAN
AccessionPrimary (citable) accession number: P0C0P6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM