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P0C0P6

- NPS_HUMAN

UniProt

P0C0P6 - NPS_HUMAN

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Protein

Neuropeptide S

Gene

NPS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations By similarity.By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. positive regulation of action potential Source: Ensembl
  3. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  4. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  5. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:NPS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:33940. NPS.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398160.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 6744PRO_0000042888Add
BLAST
Peptidei70 – 8920Neuropeptide SPRO_0000042889Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP0C0P6.
PRIDEiP0C0P6.

Expressioni

Gene expression databases

CleanExiHS_NPS.
GenevestigatoriP0C0P6.

Organism-specific databases

HPAiCAB020139.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381105.

Structurei

3D structure databases

ProteinModelPortaliP0C0P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113114.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P6.
OMAiLSTMHVF.
OrthoDBiEOG7ZD1Z5.
PhylomeDBiP0C0P6.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0P6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD
60 70 80
RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS
Length:89
Mass (Da):10,103
Last modified:November 22, 2005 - v1
Checksum:i41574555F540A7A4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141S → L.
Corresponds to variant rs990310 [ dbSNP | Ensembl ].
VAR_051239
Natural varianti75 – 751V → L.
Corresponds to variant rs4751440 [ dbSNP | Ensembl ].
VAR_051240

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BD168686 mRNA. No translation available.
AL355316 Genomic DNA. No translation available.
BC148465 mRNA. Translation: AAI48466.1.
BC156665 mRNA. Translation: AAI56666.1.
CCDSiCCDS41577.1.
RefSeqiNP_001025184.1. NM_001030013.1.
UniGeneiHs.643423.

Genome annotation databases

EnsembliENST00000398023; ENSP00000381105; ENSG00000214285.
GeneIDi594857.
KEGGihsa:594857.
UCSCiuc001ljx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BD168686 mRNA. No translation available.
AL355316 Genomic DNA. No translation available.
BC148465 mRNA. Translation: AAI48466.1 .
BC156665 mRNA. Translation: AAI56666.1 .
CCDSi CCDS41577.1.
RefSeqi NP_001025184.1. NM_001030013.1.
UniGenei Hs.643423.

3D structure databases

ProteinModelPortali P0C0P6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381105.

Proteomic databases

PaxDbi P0C0P6.
PRIDEi P0C0P6.

Protocols and materials databases

DNASUi 594857.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398023 ; ENSP00000381105 ; ENSG00000214285 .
GeneIDi 594857.
KEGGi hsa:594857.
UCSCi uc001ljx.1. human.

Organism-specific databases

CTDi 594857.
GeneCardsi GC10P129347.
HGNCi HGNC:33940. NPS.
HPAi CAB020139.
MIMi 609513. gene.
neXtProti NX_P0C0P6.
PharmGKBi PA162398160.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG113114.
GeneTreei ENSGT00400000024769.
HOGENOMi HOG000113845.
HOVERGENi HBG082056.
InParanoidi P0C0P6.
OMAi LSTMHVF.
OrthoDBi EOG7ZD1Z5.
PhylomeDBi P0C0P6.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Neuropeptide_S.
GenomeRNAii 594857.
NextBioi 112779.
PROi P0C0P6.
SOURCEi Search...

Gene expression databases

CleanExi HS_NPS.
Genevestigatori P0C0P6.

Family and domain databases

InterProi IPR028138. Neuropeptide_S.
[Graphical view ]
Pfami PF14993. Neuropeptide_S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel G protein-coupled receptor protein and its DNA."
    Sato S., Shintani Y., Miyajima N., Yoshimura K.
    Patent number WO0231145, 18-APR-2002
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: RECEPTOR IDENTIFICATION.

Entry informationi

Entry nameiNPS_HUMAN
AccessioniPrimary (citable) accession number: P0C0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3