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Protein

Neuropeptide S

Gene

NPS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S
Gene namesi
Name:NPS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:33940. NPS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398160.

Polymorphism and mutation databases

BioMutaiNPS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 6744PRO_0000042888Add
BLAST
Peptidei70 – 8920Neuropeptide SPRO_0000042889Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP0C0P6.
PRIDEiP0C0P6.

Expressioni

Gene expression databases

CleanExiHS_NPS.

Organism-specific databases

HPAiCAB020139.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381105.

Structurei

3D structure databases

ProteinModelPortaliP0C0P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113114.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P6.
OMAiFMKRSFR.
OrthoDBiEOG7ZD1Z5.
PhylomeDBiP0C0P6.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD
60 70 80
RSKELAFLKP ILEKMFVKRS FRNGVGTGMK KTSFQRAKS
Length:89
Mass (Da):10,103
Last modified:November 22, 2005 - v1
Checksum:i41574555F540A7A4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141S → L.
Corresponds to variant rs990310 [ dbSNP | Ensembl ].
VAR_051239
Natural varianti75 – 751V → L.
Corresponds to variant rs4751440 [ dbSNP | Ensembl ].
VAR_051240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168686 mRNA. No translation available.
AL355316 Genomic DNA. No translation available.
BC148465 mRNA. Translation: AAI48466.1.
BC156665 mRNA. Translation: AAI56666.1.
CCDSiCCDS41577.1.
RefSeqiNP_001025184.1. NM_001030013.1.
UniGeneiHs.643423.

Genome annotation databases

EnsembliENST00000398023; ENSP00000381105; ENSG00000214285.
GeneIDi594857.
KEGGihsa:594857.
UCSCiuc001ljx.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BD168686 mRNA. No translation available.
AL355316 Genomic DNA. No translation available.
BC148465 mRNA. Translation: AAI48466.1.
BC156665 mRNA. Translation: AAI56666.1.
CCDSiCCDS41577.1.
RefSeqiNP_001025184.1. NM_001030013.1.
UniGeneiHs.643423.

3D structure databases

ProteinModelPortaliP0C0P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381105.

Polymorphism and mutation databases

BioMutaiNPS.

Proteomic databases

PaxDbiP0C0P6.
PRIDEiP0C0P6.

Protocols and materials databases

DNASUi594857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398023; ENSP00000381105; ENSG00000214285.
GeneIDi594857.
KEGGihsa:594857.
UCSCiuc001ljx.1. human.

Organism-specific databases

CTDi594857.
GeneCardsiGC10P129347.
HGNCiHGNC:33940. NPS.
HPAiCAB020139.
MIMi609513. gene.
neXtProtiNX_P0C0P6.
PharmGKBiPA162398160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG113114.
GeneTreeiENSGT00400000024769.
HOGENOMiHOG000113845.
HOVERGENiHBG082056.
InParanoidiP0C0P6.
OMAiFMKRSFR.
OrthoDBiEOG7ZD1Z5.
PhylomeDBiP0C0P6.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiNeuropeptide_S.
GenomeRNAii594857.
NextBioi112779.
PROiP0C0P6.
SOURCEiSearch...

Gene expression databases

CleanExiHS_NPS.

Family and domain databases

InterProiIPR028138. Neuropeptide_S.
[Graphical view]
PfamiPF14993. Neuropeptide_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel G protein-coupled receptor protein and its DNA."
    Sato S., Shintani Y., Miyajima N., Yoshimura K.
    Patent number WO0231145, 18-APR-2002
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. Cited for: FUNCTION.
  5. "Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I."
    Bernier V., Stocco R., Bogusky M.J., Joyce J.G., Parachoniak C., Grenier K., Arget M., Mathieu M.C., O'Neill G.P., Slipetz D., Crackower M.A., Tan C.M., Therien A.G.
    J. Biol. Chem. 281:24704-24712(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNPS_HUMAN
AccessioniPrimary (citable) accession number: P0C0P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.