P0C0P6 (NPS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide S

Gene names

Name:

NPS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations By similarity.
Subcellular location	Secreted.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of action potential Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, glutamatergic Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 67	44			PRO_0000042888
	Peptide	70 – 89	20	Neuropeptide S		PRO_0000042889
Natural variations
	Natural variant	14	1	S → L. Corresponds to variant rs990310 [ dbSNP | Ensembl ].		VAR_051239
	Natural variant	75	1	V → L. Corresponds to variant rs4751440 [ dbSNP | Ensembl ].		VAR_051240

Sequences

	Sequence		Length	Mass (Da)
	P0C0P6 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 41574555F540A7A4	FASTA	89	10,103
	10 20 30 40 50 60 MISSVKLNLI LVLSLSTMHV FWCYPVPSSK VSGKSDYFLI LLNSCPTRLD RSKELAFLKP 70 80 ILEKMFVKRS FRNGVGTGMK KTSFQRAKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel G protein-coupled receptor protein and its DNA." Sato S., Shintani Y., Miyajima N., Yoshimura K. Patent number WO0231145, 18-APR-2002 Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects." Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z., Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L., Civelli O. Neuron 43:487-497(2004) [PubMed] [Europe PMC] [Abstract] Cited for: RECEPTOR IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BD168686 mRNA. No translation available. AL355316 Genomic DNA. No translation available. BC148465 mRNA. Translation: AAI48466.1. BC156665 mRNA. Translation: AAI56666.1.
IPI	IPI00656148.
RefSeq	NP_001025184.1. NM_001030013.1.
UniGene	Hs.643423.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381105.
Proteomic databases
PaxDb	P0C0P6.
PRIDE	P0C0P6.
Protocols and materials databases
DNASU	594857.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398023; ENSP00000381105; ENSG00000214285.
GeneID	594857.
KEGG	hsa:594857.
UCSC	uc001ljx.1. human.
Organism-specific databases
CTD	594857.
GeneCards	GC10P129347.
HGNC	HGNC:33940. NPS.
HPA	CAB020139.
MIM	609513. gene.
neXtProt	NX_P0C0P6.
PharmGKB	PA162398160.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG113114.
HOGENOM	HOG000113845.
HOVERGEN	HBG082056.
InParanoid	P0C0P6.
OMA	MKRSFRN.
OrthoDB	EOG4BP1DG.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_NPS.
Genevestigator	P0C0P6.
Family and domain databases
ProtoNet	Search...
Other
NextBio	112779.
SOURCE	Search...

Entry information

Entry name

NPS_HUMAN

Accession

Primary (citable) accession number: P0C0P6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.