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Protein

Guanylate kinase

Gene

gmk

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-891-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:SE_0885
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000001411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706101 – 207Guanylate kinaseAdd BLAST207

Proteomic databases

PRIDEiP0C0M9

Interactioni

Protein-protein interaction databases

STRINGi176280.SE0885

Structurei

3D structure databases

ProteinModelPortaliP0C0M9
SMRiP0C0M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 185Guanylate kinase-likeUniRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEKGLLIV LSGPSGVGKG TVRKKIFEDP TTSYKYSISM TTRHMREGEI
60 70 80 90 100
DGVDYFFKTK EEFEALIKDD QFIEYAQYVG NYYGTPVQYV KDTMEEGHDV
110 120 130 140 150
FLEIEVEGAK QVRKKFPDAL FIFLAPPSLD DLKERLVGRG TESDEKIQSR
160 170 180 190 200
VNEARKEVEM MNLYDYVVVN DEVELAKNRI QSIVEAEHLK RERIEAKYRK

MLLEVKK
Length:207
Mass (Da):24,065
Last modified:November 22, 2005 - v1
Checksum:i4C70F7F4BCFB8EDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO04482.1
AY163288 Genomic DNA Translation: AAO60567.1
RefSeqiNP_764440.1, NC_004461.1
WP_001830096.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO04482; AAO04482; SE_0885
GeneIDi1057432
KEGGisep:SE0885
PATRICifig|176280.10.peg.858

Similar proteinsi

Entry informationi

Entry nameiKGUA_STAES
AccessioniPrimary (citable) accession number: P0C0M9
Secondary accession number(s): Q8CSW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome