P0C0M8 (KGUA_STAEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:

gmk

Organism

Staphylococcus epidermidis

Taxonomic identifier

1282 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	130 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 130	›130	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170609
Regions
	Domain	1 – 130	130	Guanylate kinase-like
Natural variations
	Natural variant	109	1	K → R in strain: MCL8544.
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P0C0M8 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 196E9DB081333C00	FASTA	130	15,153
	10 20 30 40 50 60 KIFEDPTTSY KYSISMTTRH MREGEIDGVD YFFKTKEEFE ALIKDDQFIE YAQYVGNYYG 70 80 90 100 110 120 TPVQYVKDTM EEGHDVFLEI EVEGAKQVRK KFPDALFIFL APPSLDDLKE RLVGRGTESD 130 EKIQSRVNEA

References

[1]

"Establishment of a multilocus sequence typing system for Staphylococcus epidermidis." Anderson A.S., Wang X.-M., McClements W., Noble L., Jansen K. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MCL13231, MCL8040, MCL8192, MCL8544 and MCL8827.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY163289 Genomic DNA. Translation: AAO60568.1. AY163290 Genomic DNA. Translation: AAO60569.1. AY163291 Genomic DNA. Translation: AAO60570.1. AY163292 Genomic DNA. Translation: AAO60571.1. AY163293 Genomic DNA. Translation: AAO60572.1.
3D structure databases
ProteinModelPortal	P0C0M8.
SMR	P0C0M8. Positions 1-110.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_STAEP

Accession

Primary (citable) accession number: P0C0M8
Secondary accession number(s): Q8CSW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	January 9, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program