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P0C0M8 (KGUA_STAEP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
OrganismStaphylococcus epidermidis
Taxonomic identifier1282 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length130 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity.

Catalytic activity

ATP + GMP = ADP + GDP.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 130›130Guanylate kinase
PRO_0000170609

Regions

Domain1 – 130130Guanylate kinase-like

Natural variations

Natural variant1091K → R in strain: MCL8544.

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P0C0M8 [UniParc].

Last modified November 22, 2005. Version 1.
Checksum: 196E9DB081333C00

FASTA13015,153
        10         20         30         40         50         60 
KIFEDPTTSY KYSISMTTRH MREGEIDGVD YFFKTKEEFE ALIKDDQFIE YAQYVGNYYG 

        70         80         90        100        110        120 
TPVQYVKDTM EEGHDVFLEI EVEGAKQVRK KFPDALFIFL APPSLDDLKE RLVGRGTESD 

       130 
EKIQSRVNEA 

« Hide

References

[1]"Establishment of a multilocus sequence typing system for Staphylococcus epidermidis."
Anderson A.S., Wang X.-M., McClements W., Noble L., Jansen K.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MCL13231, MCL8040, MCL8192, MCL8544 and MCL8827.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY163289 Genomic DNA. Translation: AAO60568.1.
AY163290 Genomic DNA. Translation: AAO60569.1.
AY163291 Genomic DNA. Translation: AAO60570.1.
AY163292 Genomic DNA. Translation: AAO60571.1.
AY163293 Genomic DNA. Translation: AAO60572.1.

3D structure databases

ProteinModelPortalP0C0M8.
SMRP0C0M8. Positions 1-110.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_STAEP
AccessionPrimary (citable) accession number: P0C0M8
Secondary accession number(s): Q8CSW4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families