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Protein

Guanylate kinase

Gene

gmk

Organism
Staphylococcus epidermidis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
OrganismiStaphylococcus epidermidis
Taxonomic identifieri1282 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000170609‹1 – 130Guanylate kinaseAdd BLAST›130

Proteomic databases

PRIDEiP0C0M8

Structurei

3D structure databases

ProteinModelPortaliP0C0M8
SMRiP0C0M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 130Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

P0C0M8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KIFEDPTTSY KYSISMTTRH MREGEIDGVD YFFKTKEEFE ALIKDDQFIE
60 70 80 90 100
YAQYVGNYYG TPVQYVKDTM EEGHDVFLEI EVEGAKQVRK KFPDALFIFL
110 120 130
APPSLDDLKE RLVGRGTESD EKIQSRVNEA
Length:130
Mass (Da):15,153
Last modified:November 22, 2005 - v1
Checksum:i196E9DB081333C00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109K → R in strain: MCL8544. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163289 Genomic DNA Translation: AAO60568.1
AY163290 Genomic DNA Translation: AAO60569.1
AY163291 Genomic DNA Translation: AAO60570.1
AY163292 Genomic DNA Translation: AAO60571.1
AY163293 Genomic DNA Translation: AAO60572.1

Similar proteinsi

Entry informationi

Entry nameiKGUA_STAEP
AccessioniPrimary (citable) accession number: P0C0M8
Secondary accession number(s): Q8CSW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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