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P0C0M8

- KGUA_STAEP

UniProt

P0C0M8 - KGUA_STAEP

Protein

Guanylate kinase

Gene

gmk

Organism
Staphylococcus epidermidis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Essential for recycling GMP and indirectly, cGMP.By similarity

    Catalytic activityi

    ATP + GMP = ADP + GDP.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. guanylate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. purine nucleotide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinase (EC:2.7.4.8)
    Alternative name(s):
    GMP kinase
    Gene namesi
    Name:gmk
    OrganismiStaphylococcus epidermidis
    Taxonomic identifieri1282 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 130›130Guanylate kinasePRO_0000170609Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0M8.
    SMRiP0C0M8. Positions 1-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 130130Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P0C0M8-1 [UniParc]FASTAAdd to Basket

    « Hide

    KIFEDPTTSY KYSISMTTRH MREGEIDGVD YFFKTKEEFE ALIKDDQFIE    50
    YAQYVGNYYG TPVQYVKDTM EEGHDVFLEI EVEGAKQVRK KFPDALFIFL 100
    APPSLDDLKE RLVGRGTESD EKIQSRVNEA 130
    Length:130
    Mass (Da):15,153
    Last modified:November 22, 2005 - v1
    Checksum:i196E9DB081333C00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091K → R in strain: MCL8544.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY163289 Genomic DNA. Translation: AAO60568.1.
    AY163290 Genomic DNA. Translation: AAO60569.1.
    AY163291 Genomic DNA. Translation: AAO60570.1.
    AY163292 Genomic DNA. Translation: AAO60571.1.
    AY163293 Genomic DNA. Translation: AAO60572.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY163289 Genomic DNA. Translation: AAO60568.1 .
    AY163290 Genomic DNA. Translation: AAO60569.1 .
    AY163291 Genomic DNA. Translation: AAO60570.1 .
    AY163292 Genomic DNA. Translation: AAO60571.1 .
    AY163293 Genomic DNA. Translation: AAO60572.1 .

    3D structure databases

    ProteinModelPortali P0C0M8.
    SMRi P0C0M8. Positions 1-110.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Establishment of a multilocus sequence typing system for Staphylococcus epidermidis."
      Anderson A.S., Wang X.-M., McClements W., Noble L., Jansen K.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MCL13231, MCL8040, MCL8192, MCL8544 and MCL8827.

    Entry informationi

    Entry nameiKGUA_STAEP
    AccessioniPrimary (citable) accession number: P0C0M8
    Secondary accession number(s): Q8CSW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3