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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Staphylococcus epidermidis (strain ATCC 12228)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176280:G1G05-1719-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:SE_1669
OrganismiStaphylococcus epidermidis (strain ATCC 12228)
Taxonomic identifieri176280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035461 – 159Serine-protein kinase RsbWAdd BLAST159

Interactioni

Protein-protein interaction databases

STRINGi176280.SE1669

Structurei

3D structure databases

ProteinModelPortaliP0C0M7
SMRiP0C0M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
KOiK04757
OMAiKMGFSYE

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTQDYIEM RLPASAEYVS LIRLTLSGVF SRAGASYDDI EDSKIAVSEA
60 70 80 90 100
VTNAVKHAYK KNSEIGMINL CFEIFDDRIK IVISDQGESF DYEATKSHLG
110 120 130 140 150
PYNDNENIDF LREGGLGLFL IESLMDEVTV YKESGVTISM IKYIKKEQVR

NNGERVEIS
Length:159
Mass (Da):17,922
Last modified:November 22, 2005 - v1
Checksum:iEA6A49C76218B78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015929 Genomic DNA Translation: AAO05268.1
RefSeqiNP_765224.1, NC_004461.1
WP_001829903.1, NC_004461.1

Genome annotation databases

EnsemblBacteriaiAAO05268; AAO05268; SE_1669
GeneIDi1057850
KEGGisep:SE1669
PATRICifig|176280.10.peg.1630

Similar proteinsi

Entry informationi

Entry nameiRSBW_STAES
AccessioniPrimary (citable) accession number: P0C0M7
Secondary accession number(s): Q8VSV5, Q9F7V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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