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Protein

Protein IscX

Gene

iscX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as iron donor in the assembly of iron-sulfur clusters.

GO - Molecular functioni

  • enzyme inhibitor activity Source: EcoCyc
  • ferrous iron binding Source: EcoCyc
  • iron ion binding Source: EcoCyc

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG12311-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein IscX
Gene namesi
Name:iscX
Synonyms:yfhJ
Ordered Locus Names:b2524, JW2508
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12311 iscX

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002118531 – 66Protein IscXAdd BLAST66

Proteomic databases

PaxDbiP0C0L9
PRIDEiP0C0L9

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4260583, 9 interactors
DIPiDIP-48188N
IntActiP0C0L9, 5 interactors
STRINGi316385.ECDH10B_2691

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 18Combined sources11
Helixi24 – 26Combined sources3
Helixi29 – 37Combined sources9
Beta strandi40 – 42Combined sources3
Helixi46 – 48Combined sources3
Helixi51 – 64Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJ8X-ray1.75A2-66[»]
2BZTNMR-A1-66[»]
ProteinModelPortaliP0C0L9
SMRiP0C0L9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0L9

Family & Domainsi

Sequence similaritiesi

Belongs to the IscX family.Curated

Phylogenomic databases

eggNOGiENOG4105WVQ Bacteria
COG2975 LUCA
HOGENOMiHOG000262066
InParanoidiP0C0L9
OMAiAIQQAWI
PhylomeDBiP0C0L9

Family and domain databases

Gene3Di1.10.10.600, 1 hit
InterProiView protein in InterPro
IPR007479 ISC_FeS_clus_asmbl_IscsX
IPR036762 IscX-like_sf
PANTHERiPTHR37532 PTHR37532, 1 hit
PfamiView protein in Pfam
PF04384 Fe-S_assembly, 1 hit
PIRSFiPIRSF039003 IscX, 1 hit
SUPFAMiSSF140319 SSF140319, 1 hit
TIGRFAMsiTIGR03412 iscX_yfhJ, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKWTDSRE IGEALYDAYP DLDPKTVRFT DMHQWICDLE DFDDDPQASN
60
EKILEAILLV WLDEAE
Length:66
Mass (Da):7,732
Last modified:November 22, 2005 - v1
Checksum:i31C176F0C906AAD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 51DDDPQASNE → RTDPGIPTK (PubMed:8300516).Curated9
Sequence conflicti55E → R (PubMed:8300516).Curated1
Sequence conflicti58 – 66LLVWLDEAE → C (PubMed:8300516).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88654 Genomic DNA No translation available.
U01827 Unassigned DNA No translation available.
U00096 Genomic DNA Translation: AAC75577.1
AP009048 Genomic DNA Translation: BAA16414.1
PIRiC65029
RefSeqiNP_417019.1, NC_000913.3
WP_000523616.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75577; AAC75577; b2524
BAA16414; BAA16414; BAA16414
GeneIDi945196
KEGGiecj:JW2508
eco:b2524
PATRICifig|1411691.4.peg.4210

Similar proteinsi

Entry informationi

Entry nameiISCX_ECOLI
AccessioniPrimary (citable) accession number: P0C0L9
Secondary accession number(s): P37096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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