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Protein

Protein IscX

Gene

iscX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as iron donor in the assembly of iron-sulfur clusters.

GO - Molecular functioni

  • enzyme inhibitor activity Source: EcoCyc
  • ferrous iron binding Source: EcoCyc
  • iron ion binding Source: EcoCyc

GO - Biological processi

  • iron-sulfur cluster assembly Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12311-MONOMER.
ECOL316407:JW2508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein IscX
Gene namesi
Name:iscX
Synonyms:yfhJ
Ordered Locus Names:b2524, JW2508
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12311. iscX.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Protein IscXPRO_0000211853Add
BLAST

Proteomic databases

PaxDbiP0C0L9.
PRIDEiP0C0L9.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4260583. 8 interactions.
DIPiDIP-48188N.
IntActiP0C0L9. 5 interactions.
STRINGi511145.b2524.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 1811Combined sources
Helixi24 – 263Combined sources
Helixi29 – 379Combined sources
Beta strandi40 – 423Combined sources
Helixi46 – 483Combined sources
Helixi51 – 6414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJ8X-ray1.75A2-66[»]
2BZTNMR-A1-66[»]
ProteinModelPortaliP0C0L9.
SMRiP0C0L9. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0L9.

Family & Domainsi

Sequence similaritiesi

Belongs to the IscX family.Curated

Phylogenomic databases

eggNOGiENOG4105WVQ. Bacteria.
COG2975. LUCA.
HOGENOMiHOG000262066.
InParanoidiP0C0L9.
OMAiAIQQAWI.
PhylomeDBiP0C0L9.

Family and domain databases

Gene3Di1.10.10.600. 1 hit.
InterProiIPR007479. ISC_FeS_clus_asmbl_IscsX.
[Graphical view]
PfamiPF04384. Fe-S_assembly. 1 hit.
[Graphical view]
PIRSFiPIRSF039003. IscX. 1 hit.
SUPFAMiSSF140319. SSF140319. 1 hit.
TIGRFAMsiTIGR03412. iscX_yfhJ. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKWTDSRE IGEALYDAYP DLDPKTVRFT DMHQWICDLE DFDDDPQASN
60
EKILEAILLV WLDEAE
Length:66
Mass (Da):7,732
Last modified:November 22, 2005 - v1
Checksum:i31C176F0C906AAD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 519DDDPQASNE → RTDPGIPTK (PubMed:8300516).Curated
Sequence conflicti55 – 551E → R (PubMed:8300516).Curated
Sequence conflicti58 – 669LLVWLDEAE → C (PubMed:8300516).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88654 Genomic DNA. No translation available.
U01827 Unassigned DNA. No translation available.
U00096 Genomic DNA. Translation: AAC75577.1.
AP009048 Genomic DNA. Translation: BAA16414.1.
PIRiC65029.
RefSeqiNP_417019.1. NC_000913.3.
WP_000523616.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75577; AAC75577; b2524.
BAA16414; BAA16414; BAA16414.
GeneIDi945196.
KEGGiecj:JW2508.
eco:b2524.
PATRICi32120443. VBIEscCol129921_2624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88654 Genomic DNA. No translation available.
U01827 Unassigned DNA. No translation available.
U00096 Genomic DNA. Translation: AAC75577.1.
AP009048 Genomic DNA. Translation: BAA16414.1.
PIRiC65029.
RefSeqiNP_417019.1. NC_000913.3.
WP_000523616.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UJ8X-ray1.75A2-66[»]
2BZTNMR-A1-66[»]
ProteinModelPortaliP0C0L9.
SMRiP0C0L9. Positions 1-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260583. 8 interactions.
DIPiDIP-48188N.
IntActiP0C0L9. 5 interactions.
STRINGi511145.b2524.

Proteomic databases

PaxDbiP0C0L9.
PRIDEiP0C0L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75577; AAC75577; b2524.
BAA16414; BAA16414; BAA16414.
GeneIDi945196.
KEGGiecj:JW2508.
eco:b2524.
PATRICi32120443. VBIEscCol129921_2624.

Organism-specific databases

EchoBASEiEB2217.
EcoGeneiEG12311. iscX.

Phylogenomic databases

eggNOGiENOG4105WVQ. Bacteria.
COG2975. LUCA.
HOGENOMiHOG000262066.
InParanoidiP0C0L9.
OMAiAIQQAWI.
PhylomeDBiP0C0L9.

Enzyme and pathway databases

BioCyciEcoCyc:EG12311-MONOMER.
ECOL316407:JW2508-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0C0L9.
PROiP0C0L9.

Family and domain databases

Gene3Di1.10.10.600. 1 hit.
InterProiIPR007479. ISC_FeS_clus_asmbl_IscsX.
[Graphical view]
PfamiPF04384. Fe-S_assembly. 1 hit.
[Graphical view]
PIRSFiPIRSF039003. IscX. 1 hit.
SUPFAMiSSF140319. SSF140319. 1 hit.
TIGRFAMsiTIGR03412. iscX_yfhJ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiISCX_ECOLI
AccessioniPrimary (citable) accession number: P0C0L9
Secondary accession number(s): P37096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.