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P0C0L6

- NPSR1_RAT

UniProt

P0C0L6 - NPSR1_RAT

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Protein

Neuropeptide S receptor

Gene
Npsr1, Gpr154
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth By similarity.

GO - Molecular functioni

  1. neuropeptide receptor activity Source: InterPro
  2. vasopressin receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S receptor
Alternative name(s):
G-protein coupled receptor 154
Gene namesi
Name:Npsr1
Synonyms:Gpr154
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1564154. Npsr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252Extracellular Reviewed predictionAdd
BLAST
Transmembranei53 – 7321Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini74 – 829Cytoplasmic Reviewed prediction
Transmembranei83 – 10321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini104 – 12219Extracellular Reviewed predictionAdd
BLAST
Transmembranei123 – 14321Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini144 – 16522Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei166 – 18621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini187 – 21327Extracellular Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini235 – 27642Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei277 – 29721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini298 – 31316Extracellular Reviewed predictionAdd
BLAST
Transmembranei314 – 33421Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini335 – 37238Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Neuropeptide S receptorPRO_0000069642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi121 ↔ 198 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C0L6.
PRIDEiP0C0L6.

PTM databases

PhosphoSiteiP0C0L6.

Expressioni

Gene expression databases

GenevestigatoriP0C0L6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021625.

Structurei

3D structure databases

ProteinModelPortaliP0C0L6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00740000115220.
HOGENOMiHOG000220789.
HOVERGENiHBG106615.
InParanoidiP0C0L6.
OMAiTIWMKSK.
OrthoDBiEOG776SQ9.
PhylomeDBiP0C0L6.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0L6-1 [UniParc]FASTAAdd to Basket

« Hide

MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALEAEE WGSFYSSFKT    50
EQLITLWVLF VFTIVGNSVV LFSTWRRKRK SRMTFFVTQL AITDSFTGLI 100
NILTDIIWRF TGDFMAPDLV CRIVRYLQVV LLYASTYVLV SLSIDRYHAI 150
VYPMKFLQGA EKQAKVLIGI AWSLSFLFSI PTLIIFGKRT LSNGEVQCWA 200
LWPDDSYWTP YMTIVAFLVY FIPLTIISVI YGLVIRTIWI KSKAHETVIS 250
NCSDGELCCS YNRGLISKAK IKAIKYSIVI ILAFICCWSP YFLFDMLDNF 300
NLLPDTKERF YASVIIQNLP ALNSAINPLI YCIFSGSLCS PCKVQRSQDS 350
RMTYRERSER HEMQILSKPE FI 372
Length:372
Mass (Da):42,638
Last modified:November 8, 2005 - v1
Checksum:i896230261D77BDDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03062350 Genomic DNA. No translation available.
AABR03063281 Genomic DNA. No translation available.
AABR03064185 Genomic DNA. No translation available.
CB812328 mRNA. No translation available.
UniGeneiRn.101463.

Genome annotation databases

EnsembliENSRNOT00000021625; ENSRNOP00000021625; ENSRNOG00000015863.
UCSCiRGD:1564154. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03062350 Genomic DNA. No translation available.
AABR03063281 Genomic DNA. No translation available.
AABR03064185 Genomic DNA. No translation available.
CB812328 mRNA. No translation available.
UniGenei Rn.101463.

3D structure databases

ProteinModelPortali P0C0L6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021625.

Chemistry

GuidetoPHARMACOLOGYi 302.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P0C0L6.

Proteomic databases

PaxDbi P0C0L6.
PRIDEi P0C0L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021625 ; ENSRNOP00000021625 ; ENSRNOG00000015863 .
UCSCi RGD:1564154. rat.

Organism-specific databases

RGDi 1564154. Npsr1.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00740000115220.
HOGENOMi HOG000220789.
HOVERGENi HBG106615.
InParanoidi P0C0L6.
OMAi TIWMKSK.
OrthoDBi EOG776SQ9.
PhylomeDBi P0C0L6.
TreeFami TF106499.

Miscellaneous databases

PROi P0C0L6.

Gene expression databases

Genevestigatori P0C0L6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view ]
PANTHERi PTHR24244:SF2. PTHR24244:SF2. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Amgen rat EST program."
    Amgen EST program
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-103.

Entry informationi

Entry nameiNPSR1_RAT
AccessioniPrimary (citable) accession number: P0C0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi