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Protein

Neuropeptide S receptor

Gene

Npsr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca2+ stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.By similarity

GO - Molecular functioni

GO - Biological processi

  • eating behavior Source: RGD
  • negative regulation of defecation Source: RGD
  • negative regulation of eating behavior Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • righting reflex Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_306851. Peptide ligand-binding receptors.
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide S receptor
Alternative name(s):
G-protein coupled receptor 154
Gene namesi
Name:Npsr1
Synonyms:Gpr154
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1564154. Npsr1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini74 – 829CytoplasmicSequence Analysis
Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini104 – 12219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini144 – 16522CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini187 – 21327ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini235 – 27642CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini298 – 31316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini335 – 37238CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Neuropeptide S receptorPRO_0000069642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP0C0L6.
PRIDEiP0C0L6.

PTM databases

PhosphoSiteiP0C0L6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021625.

Structurei

3D structure databases

ProteinModelPortaliP0C0L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000220789.
HOVERGENiHBG106615.
InParanoidiP0C0L6.
OMAiTIISIMY.
OrthoDBiEOG776SQ9.
PhylomeDBiP0C0L6.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALEAEE WGSFYSSFKT
60 70 80 90 100
EQLITLWVLF VFTIVGNSVV LFSTWRRKRK SRMTFFVTQL AITDSFTGLI
110 120 130 140 150
NILTDIIWRF TGDFMAPDLV CRIVRYLQVV LLYASTYVLV SLSIDRYHAI
160 170 180 190 200
VYPMKFLQGA EKQAKVLIGI AWSLSFLFSI PTLIIFGKRT LSNGEVQCWA
210 220 230 240 250
LWPDDSYWTP YMTIVAFLVY FIPLTIISVI YGLVIRTIWI KSKAHETVIS
260 270 280 290 300
NCSDGELCCS YNRGLISKAK IKAIKYSIVI ILAFICCWSP YFLFDMLDNF
310 320 330 340 350
NLLPDTKERF YASVIIQNLP ALNSAINPLI YCIFSGSLCS PCKVQRSQDS
360 370
RMTYRERSER HEMQILSKPE FI
Length:372
Mass (Da):42,638
Last modified:November 8, 2005 - v1
Checksum:i896230261D77BDDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03062350 Genomic DNA. No translation available.
AABR03063281 Genomic DNA. No translation available.
AABR03064185 Genomic DNA. No translation available.
CB812328 mRNA. No translation available.
UniGeneiRn.101463.

Genome annotation databases

EnsembliENSRNOT00000021625; ENSRNOP00000021625; ENSRNOG00000015863.
UCSCiRGD:1564154. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03062350 Genomic DNA. No translation available.
AABR03063281 Genomic DNA. No translation available.
AABR03064185 Genomic DNA. No translation available.
CB812328 mRNA. No translation available.
UniGeneiRn.101463.

3D structure databases

ProteinModelPortaliP0C0L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021625.

Chemistry

GuidetoPHARMACOLOGYi302.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP0C0L6.

Proteomic databases

PaxDbiP0C0L6.
PRIDEiP0C0L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021625; ENSRNOP00000021625; ENSRNOG00000015863.
UCSCiRGD:1564154. rat.

Organism-specific databases

RGDi1564154. Npsr1.

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000220789.
HOVERGENiHBG106615.
InParanoidiP0C0L6.
OMAiTIISIMY.
OrthoDBiEOG776SQ9.
PhylomeDBiP0C0L6.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_306851. Peptide ligand-binding receptors.
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

PROiP0C0L6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Amgen rat EST program."
    Amgen EST program
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-103.

Entry informationi

Entry nameiNPSR1_RAT
AccessioniPrimary (citable) accession number: P0C0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.