Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0C0L6 (NPSR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide S receptor
Alternative name(s):
G-protein coupled receptor 154
Gene names
Name:Npsr1
Synonyms:Gpr154
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Neuropeptide S receptor
PRO_0000069642

Regions

Topological domain1 – 5252Extracellular Potential
Transmembrane53 – 7321Helical; Name=1; Potential
Topological domain74 – 829Cytoplasmic Potential
Transmembrane83 – 10321Helical; Name=2; Potential
Topological domain104 – 12219Extracellular Potential
Transmembrane123 – 14321Helical; Name=3; Potential
Topological domain144 – 16522Cytoplasmic Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Topological domain187 – 21327Extracellular Potential
Transmembrane214 – 23421Helical; Name=5; Potential
Topological domain235 – 27642Cytoplasmic Potential
Transmembrane277 – 29721Helical; Name=6; Potential
Topological domain298 – 31316Extracellular Potential
Transmembrane314 – 33421Helical; Name=7; Potential
Topological domain335 – 37238Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C0L6 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 896230261D77BDDE

FASTA37242,638
        10         20         30         40         50         60 
MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALEAEE WGSFYSSFKT EQLITLWVLF 

        70         80         90        100        110        120 
VFTIVGNSVV LFSTWRRKRK SRMTFFVTQL AITDSFTGLI NILTDIIWRF TGDFMAPDLV 

       130        140        150        160        170        180 
CRIVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGA EKQAKVLIGI AWSLSFLFSI 

       190        200        210        220        230        240 
PTLIIFGKRT LSNGEVQCWA LWPDDSYWTP YMTIVAFLVY FIPLTIISVI YGLVIRTIWI 

       250        260        270        280        290        300 
KSKAHETVIS NCSDGELCCS YNRGLISKAK IKAIKYSIVI ILAFICCWSP YFLFDMLDNF 

       310        320        330        340        350        360 
NLLPDTKERF YASVIIQNLP ALNSAINPLI YCIFSGSLCS PCKVQRSQDS RMTYRERSER 

       370 
HEMQILSKPE FI 

« Hide

References

[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"Amgen rat EST program."
Amgen EST program
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-103.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR03062350 Genomic DNA. No translation available.
AABR03063281 Genomic DNA. No translation available.
AABR03064185 Genomic DNA. No translation available.
CB812328 mRNA. No translation available.
UniGeneRn.101463.

3D structure databases

ProteinModelPortalP0C0L6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021625.

Chemistry

GuidetoPHARMACOLOGY302.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP0C0L6.

Proteomic databases

PaxDbP0C0L6.
PRIDEP0C0L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021625; ENSRNOP00000021625; ENSRNOG00000015863.
UCSCRGD:1564154. rat.

Organism-specific databases

RGD1564154. Npsr1.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00740000115220.
HOGENOMHOG000220789.
HOVERGENHBG106615.
InParanoidP0C0L6.
OMATIWMKSK.
OrthoDBEOG776SQ9.
PhylomeDBP0C0L6.
TreeFamTF106499.

Gene expression databases

GenevestigatorP0C0L6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027294. NPS_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERPTHR24244:SF2. PTHR24244:SF2. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP0C0L6.

Entry information

Entry nameNPSR1_RAT
AccessionPrimary (citable) accession number: P0C0L6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries