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P0C0L6

- NPSR1_RAT

UniProt

P0C0L6 - NPSR1_RAT

Protein

Neuropeptide S receptor

Gene

Npsr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    May be active in signaling pathway in an autocrine or paracrine fashion in several tissues. Receptor for neuropeptide S, it may mediate its action, such as inhibitory effects, on cell growth By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide receptor activity Source: InterPro
    2. vasopressin receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide S receptor
    Alternative name(s):
    G-protein coupled receptor 154
    Gene namesi
    Name:Npsr1
    Synonyms:Gpr154
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1564154. Npsr1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Neuropeptide S receptorPRO_0000069642Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 198PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP0C0L6.
    PRIDEiP0C0L6.

    PTM databases

    PhosphoSiteiP0C0L6.

    Expressioni

    Gene expression databases

    GenevestigatoriP0C0L6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021625.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0L6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 829CytoplasmicSequence Analysis
    Topological domaini104 – 12219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini144 – 16522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini187 – 21327ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 27642CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 37238CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00740000115220.
    HOGENOMiHOG000220789.
    HOVERGENiHBG106615.
    InParanoidiP0C0L6.
    OMAiTIWMKSK.
    OrthoDBiEOG776SQ9.
    PhylomeDBiP0C0L6.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027294. NPS_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view]
    PANTHERiPTHR24244:SF2. PTHR24244:SF2. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0C0L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPANLTEGSF HANQTVPMLD SSPVACTEIV TFTEALEAEE WGSFYSSFKT    50
    EQLITLWVLF VFTIVGNSVV LFSTWRRKRK SRMTFFVTQL AITDSFTGLI 100
    NILTDIIWRF TGDFMAPDLV CRIVRYLQVV LLYASTYVLV SLSIDRYHAI 150
    VYPMKFLQGA EKQAKVLIGI AWSLSFLFSI PTLIIFGKRT LSNGEVQCWA 200
    LWPDDSYWTP YMTIVAFLVY FIPLTIISVI YGLVIRTIWI KSKAHETVIS 250
    NCSDGELCCS YNRGLISKAK IKAIKYSIVI ILAFICCWSP YFLFDMLDNF 300
    NLLPDTKERF YASVIIQNLP ALNSAINPLI YCIFSGSLCS PCKVQRSQDS 350
    RMTYRERSER HEMQILSKPE FI 372
    Length:372
    Mass (Da):42,638
    Last modified:November 8, 2005 - v1
    Checksum:i896230261D77BDDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03062350 Genomic DNA. No translation available.
    AABR03063281 Genomic DNA. No translation available.
    AABR03064185 Genomic DNA. No translation available.
    CB812328 mRNA. No translation available.
    UniGeneiRn.101463.

    Genome annotation databases

    EnsembliENSRNOT00000021625; ENSRNOP00000021625; ENSRNOG00000015863.
    UCSCiRGD:1564154. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03062350 Genomic DNA. No translation available.
    AABR03063281 Genomic DNA. No translation available.
    AABR03064185 Genomic DNA. No translation available.
    CB812328 mRNA. No translation available.
    UniGenei Rn.101463.

    3D structure databases

    ProteinModelPortali P0C0L6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021625.

    Chemistry

    GuidetoPHARMACOLOGYi 302.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P0C0L6.

    Proteomic databases

    PaxDbi P0C0L6.
    PRIDEi P0C0L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021625 ; ENSRNOP00000021625 ; ENSRNOG00000015863 .
    UCSCi RGD:1564154. rat.

    Organism-specific databases

    RGDi 1564154. Npsr1.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00740000115220.
    HOGENOMi HOG000220789.
    HOVERGENi HBG106615.
    InParanoidi P0C0L6.
    OMAi TIWMKSK.
    OrthoDBi EOG776SQ9.
    PhylomeDBi P0C0L6.
    TreeFami TF106499.

    Miscellaneous databases

    PROi P0C0L6.

    Gene expression databases

    Genevestigatori P0C0L6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027294. NPS_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view ]
    PANTHERi PTHR24244:SF2. PTHR24244:SF2. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Amgen rat EST program."
      Amgen EST program
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-103.

    Entry informationi

    Entry nameiNPSR1_RAT
    AccessioniPrimary (citable) accession number: P0C0L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3