Reviewed, UniProtKB/Swiss-Prot P0C0L3 (OSMC_SHIFL)

Names and origin

Protein names

Recommended name:
    Peroxiredoxin osmC
    EC=1.11.1.15
Alternative name(s):
    Osmotically-inducible protein C

Gene names

Name:	osmC
Ordered Locus Names:	SF1743, S1876

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the osmC/ohr family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 143	142	Peroxiredoxin osmC		PRO_0000172730
Amino acid modifications
	Modified residue	16	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C0L3-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: A9096964BC962569	FASTA	143	15,088
	10 20 30 40 50 60 MTIHKKGQAH WEGDIKRGKG TVSTESGVLN QQPYGFNTRF EGEKGTNPEE LIGAAHAACF 70 80 90 100 110 120 SMALSLMLGE AGFTPTSIDT TADVSLDKVD AGFAITKIAL KSEVAVPGID ASTFDGIIQK 130 140 AKAGCPVSQV LKAEITLDYQ LKS

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005674 Genomic DNA. Translation: AAN43315.1. AE014073 Genomic DNA. Translation: AAP17201.1.
RefSeq	NP_707608.1. NP_837392.1.
3D structure databases
SMR	P0C0L3. Positions 1-143.
ModBase	Search...
Genome annotation databases
GeneID	1024939. 1078207.
GenomeReviews	Gene locus S1876 in contig AE014073_GR. Gene locus SF1743 in contig AE005674_GR.
KEGG	sfl:SF1743. sfx:S1876.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0C0L3.
Enzyme and pathway databases
BioCyc	SFLE198214:AAN43315.1-MON.
Family and domain databases
InterPro	IPR015946. KH-like_a/b. IPR003718. OsmC. [Graphical view]
Gene3D	G3DSA:3.30.300.20. KH_prok. 1 hit.
Pfam	PF02566. OsmC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OSMC_SHIFL

Accession

Primary (citable) accession number: P0C0L3
Secondary accession number(s): P23929, P77655

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)