ID OSMC_ECOLI Reviewed; 143 AA. AC P0C0L2; P23929; P77655; DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 16-JUN-2009, entry version 37. DE RecName: Full=Peroxiredoxin osmC; DE EC=1.11.1.15; DE AltName: Full=Osmotically-inducible protein C; GN Name=osmC; OrderedLocusNames=b1482, JW1477; OS Escherichia coli (strain K12). OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139. RC STRAIN=K12; RX MEDLINE=91350191; PubMed=1715407; DOI=10.1016/0022-2836(91)90366-E; RA Gutierrez C., Devedjian J.C.; RT "Osmotic induction of gene osmC expression in Escherichia coli K12."; RL J. Mol. Biol. 220:959-973(1991). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX MEDLINE=97251357; PubMed=9097039; DOI=10.1093/dnares/3.6.363; RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T., RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., RA Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., RA Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., RA Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J., RA Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.; RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome RT corresponding to the 28.0-40.1 min region on the linkage map."; RL DNA Res. 3:363-377(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., RA Mau B., Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1474(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains RT MG1655 and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [5] RP PARTIAL PROTEIN SEQUENCE OF 2-13. RC STRAIN=K12 / EMG2; RX MEDLINE=97443975; PubMed=9298646; DOI=10.1002/elps.1150180807; RA Link A.J., Robison K., Church G.M.; RT "Comparing the predicted and observed properties of proteins encoded RT in the genome of Escherichia coli K-12."; RL Electrophoresis 18:1259-1313(1997). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-16, AND MASS SPECTROMETRY. RX PubMed=18723842; DOI=10.1074/mcp.M800187-MCP200; RA Zhang J., Sprung R., Pei J., Tan X., Kim S., Zhu H., Liu C.F., RA Grishin N.V., Zhao Y.; RT "Lysine acetylation is a highly abundant and evolutionarily conserved RT modification in Escherichia coli."; RL Mol. Cell. Proteomics 8:215-225(2009). RN [7] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), AND FUNCTION. RX MEDLINE=22990205; PubMed=14627744; DOI=10.1110/ps.03375603; RA Lesniak J., Barton W.A., Nikolov D.B.; RT "Structural and functional features of the Escherichia coli RT hydroperoxide resistance protein OsmC."; RL Protein Sci. 12:2838-2843(2003). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS). RX PubMed=15103136; DOI=10.1107/S0907444904005013; RA Shin D.H., Choi I.G., Busso D., Jancarik J., Yokota H., Kim R., RA Kim S.H.; RT "Structure of OsmC from Escherichia coli: a salt-shock-induced RT protein."; RL Acta Crystallogr. D 60:903-911(2004). CC -!- FUNCTION: Preferentially metabolizes organic hydroperoxides over CC inorganic hydrogen peroxide. CC -!- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- INDUCTION: By elevated osmotic pressure in the growth medium. CC -!- SIMILARITY: Belongs to the osmC/ohr family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X57433; CAA40680.1; -; Genomic_DNA. DR EMBL; U00096; AAC74555.1; -; Genomic_DNA. DR EMBL; AP009048; BAA15128.1; -; Genomic_DNA. DR PIR; E64901; E64901. DR RefSeq; AP_002105.1; -. DR RefSeq; NP_415999.1; -. DR PDB; 1NYE; X-ray; 2.40 A; A/B/C/D/E/F=1-143. DR PDB; 1QWI; X-ray; 1.80 A; A/B/C/D=1-143. DR PDBsum; 1NYE; -. DR PDBsum; 1QWI; -. DR GeneID; 946043; -. DR GenomeReviews; AP009048_GR; JW1477. DR GenomeReviews; U00096_GR; b1482. DR KEGG; ecj:JW1477; -. DR KEGG; eco:b1482; -. DR EchoBASE; EB0674; -. DR EcoGene; EG10680; osmC. DR HOGENOM; P0C0L2; -. DR OMA; P0C0L2; YGFASRF. DR BioCyc; EcoCyc:EG10680-MON; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0051920; F:peroxiredoxin activity; IEA:EC. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0006950; P:response to stress; IEA:InterPro. DR InterPro; IPR015946; KH-like_a/b. DR InterPro; IPR003718; Peroxiredoxin_OsmC-like. DR InterPro; IPR019904; Peroxiredoxin_OsmC_subgr. DR Gene3D; G3DSA:3.30.300.20; KH_prok; 1. DR Pfam; PF02566; OsmC; 1. DR TIGRFAMs; TIGR03562; Osmo_induc_OsmC; 1. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; KW Direct protein sequencing; Oxidoreductase; Peroxidase. FT INIT_MET 1 1 Removed. FT CHAIN 2 143 Peroxiredoxin osmC. FT /FTId=PRO_0000172729. FT MOD_RES 16 16 N6-acetyllysine. FT STRAND 3 13 FT TURN 15 17 FT STRAND 19 34 FT HELIX 36 40 FT HELIX 48 69 FT TURN 70 72 FT STRAND 76 89 FT STRAND 92 105 FT HELIX 111 124 FT HELIX 126 130 FT STRAND 133 142 SQ SEQUENCE 143 AA; 15088 MW; A9096964BC962569 CRC64; MTIHKKGQAH WEGDIKRGKG TVSTESGVLN QQPYGFNTRF EGEKGTNPEE LIGAAHAACF SMALSLMLGE AGFTPTSIDT TADVSLDKVD AGFAITKIAL KSEVAVPGID ASTFDGIIQK AKAGCPVSQV LKAEITLDYQ LKS //