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Protein

Peroxiredoxin OsmC

Gene

osmC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide.1 Publication

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

GO - Molecular functioni

  • peroxidase activity Source: EcoCyc
  • peroxiredoxin activity Source: EcoCyc

GO - Biological processi

  • hyperosmotic response Source: EcoCyc
  • response to hydroperoxide Source: EcoCyc
  • response to oxidative stress Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciEcoCyc:EG10680-MONOMER.
ECOL316407:JW1477-MONOMER.
MetaCyc:EG10680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxiredoxin OsmC (EC:1.11.1.15)
Alternative name(s):
Osmotically-inducible protein C
Gene namesi
Name:osmC
Ordered Locus Names:b1482, JW1477
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10680. osmC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001727292 – 143Peroxiredoxin OsmCAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0C0L2.
PaxDbiP0C0L2.
PRIDEiP0C0L2.

Expressioni

Inductioni

By elevated osmotic pressure in the growth medium.

Interactioni

Protein-protein interaction databases

BioGridi4260206. 228 interactors.
DIPiDIP-48058N.
IntActiP0C0L2. 11 interactors.
STRINGi511145.b1482.

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Beta strandi15 – 17Combined sources3
Beta strandi19 – 24Combined sources6
Beta strandi27 – 34Combined sources8
Helixi36 – 40Combined sources5
Helixi48 – 70Combined sources23
Beta strandi76 – 89Combined sources14
Beta strandi92 – 105Combined sources14
Helixi111 – 124Combined sources14
Helixi126 – 130Combined sources5
Beta strandi133 – 142Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYEX-ray2.40A/B/C/D/E/F1-143[»]
1QWIX-ray1.80A/B/C/D1-143[»]
ProteinModelPortaliP0C0L2.
SMRiP0C0L2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0C0L2.

Family & Domainsi

Sequence similaritiesi

Belongs to the OsmC/Ohr family.Curated

Phylogenomic databases

eggNOGiENOG4108Z9K. Bacteria.
COG1764. LUCA.
HOGENOMiHOG000060052.
InParanoidiP0C0L2.
KOiK04063.
OMAiWQGGIKD.
PhylomeDBiP0C0L2.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
InterProiIPR015946. KH_dom-like_a/b.
IPR003718. OsmC/Ohr_fam.
IPR019904. Peroxiredoxin_OsmC.
[Graphical view]
PfamiPF02566. OsmC. 1 hit.
[Graphical view]
SUPFAMiSSF82784. SSF82784. 1 hit.
TIGRFAMsiTIGR03562. osmo_induc_OsmC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHKKGQAH WEGDIKRGKG TVSTESGVLN QQPYGFNTRF EGEKGTNPEE
60 70 80 90 100
LIGAAHAACF SMALSLMLGE AGFTPTSIDT TADVSLDKVD AGFAITKIAL
110 120 130 140
KSEVAVPGID ASTFDGIIQK AKAGCPVSQV LKAEITLDYQ LKS
Length:143
Mass (Da):15,088
Last modified:January 23, 2007 - v2
Checksum:iA9096964BC962569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57433 Genomic DNA. Translation: CAA40680.1.
U00096 Genomic DNA. Translation: AAC74555.1.
AP009048 Genomic DNA. Translation: BAA15128.1.
PIRiE64901.
RefSeqiNP_415999.1. NC_000913.3.
WP_000152305.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74555; AAC74555; b1482.
BAA15128; BAA15128; BAA15128.
GeneIDi946043.
KEGGiecj:JW1477.
eco:b1482.
PATRICi32118258. VBIEscCol129921_1549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57433 Genomic DNA. Translation: CAA40680.1.
U00096 Genomic DNA. Translation: AAC74555.1.
AP009048 Genomic DNA. Translation: BAA15128.1.
PIRiE64901.
RefSeqiNP_415999.1. NC_000913.3.
WP_000152305.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYEX-ray2.40A/B/C/D/E/F1-143[»]
1QWIX-ray1.80A/B/C/D1-143[»]
ProteinModelPortaliP0C0L2.
SMRiP0C0L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260206. 228 interactors.
DIPiDIP-48058N.
IntActiP0C0L2. 11 interactors.
STRINGi511145.b1482.

Proteomic databases

EPDiP0C0L2.
PaxDbiP0C0L2.
PRIDEiP0C0L2.

Protocols and materials databases

DNASUi946043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74555; AAC74555; b1482.
BAA15128; BAA15128; BAA15128.
GeneIDi946043.
KEGGiecj:JW1477.
eco:b1482.
PATRICi32118258. VBIEscCol129921_1549.

Organism-specific databases

EchoBASEiEB0674.
EcoGeneiEG10680. osmC.

Phylogenomic databases

eggNOGiENOG4108Z9K. Bacteria.
COG1764. LUCA.
HOGENOMiHOG000060052.
InParanoidiP0C0L2.
KOiK04063.
OMAiWQGGIKD.
PhylomeDBiP0C0L2.

Enzyme and pathway databases

BioCyciEcoCyc:EG10680-MONOMER.
ECOL316407:JW1477-MONOMER.
MetaCyc:EG10680-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0C0L2.
PROiP0C0L2.

Family and domain databases

Gene3Di3.30.300.20. 1 hit.
InterProiIPR015946. KH_dom-like_a/b.
IPR003718. OsmC/Ohr_fam.
IPR019904. Peroxiredoxin_OsmC.
[Graphical view]
PfamiPF02566. OsmC. 1 hit.
[Graphical view]
SUPFAMiSSF82784. SSF82784. 1 hit.
TIGRFAMsiTIGR03562. osmo_induc_OsmC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOSMC_ECOLI
AccessioniPrimary (citable) accession number: P0C0L2
Secondary accession number(s): P23929, P77655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.