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P0C0I9

- HASC1_STRP1

UniProt

P0C0I9 - HASC1_STRP1

Protein

UTP--glucose-1-phosphate uridylyltransferase 1

Gene

hasC1

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1796-MONOMER.
    SPYO293653:GHFC-1934-MONOMER.
    UniPathwayiUPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 1 (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
    UDP-glucose pyrophosphorylase 1
    Short name:
    UDPGP 1
    Uridine diphosphoglucose pyrophosphorylase 1
    Gene namesi
    Name:hasC1
    Synonyms:hasC
    Ordered Locus Names:SPy_2202, M5005_Spy1853
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304UTP--glucose-1-phosphate uridylyltransferase 1PRO_0000201368Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_2202.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0I9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiSRINIHY.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0C0I9-1 [UniParc]FASTAAdd to Basket

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    MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
    EEILVVTGKA KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF 100
    IRQSHPRGLG DAVLQAKAFV GNEPFVVMLG DDLMDITNAS AKPLTKQLME 150
    DYDKTHASTI AVMKVPHEDV SSYGVIAPQG KAVKGLYSVD TFVEKPQPED 200
    APSDLAIIGR YLLTPEIFGI LERQTPGAGN EVQLTDAIDT LNKTQRVFAR 250
    EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP 300
    THSK 304
    Length:304
    Mass (Da):33,650
    Last modified:September 13, 2005 - v1
    Checksum:i48149D764B5E2BEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34830.1.
    CP000017 Genomic DNA. Translation: AAZ52471.1.
    RefSeqiNP_270109.1. NC_002737.1.
    YP_283216.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34830; AAK34830; SPy_2202.
    AAZ52471; AAZ52471; M5005_Spy1853.
    GeneIDi3571025.
    901878.
    KEGGispy:SPy_2202.
    spz:M5005_Spy_1853.
    PATRICi19717727. VBIStrPyo79812_1907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34830.1 .
    CP000017 Genomic DNA. Translation: AAZ52471.1 .
    RefSeqi NP_270109.1. NC_002737.1.
    YP_283216.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P0C0I9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_2202.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34830 ; AAK34830 ; SPy_2202 .
    AAZ52471 ; AAZ52471 ; M5005_Spy1853 .
    GeneIDi 3571025.
    901878.
    KEGGi spy:SPy_2202.
    spz:M5005_Spy_1853.
    PATRICi 19717727. VBIStrPyo79812_1907.

    Phylogenomic databases

    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi SRINIHY.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00215 .
    BioCyci SPYO160490:GJ81-1796-MONOMER.
    SPYO293653:GHFC-1934-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiHASC1_STRP1
    AccessioniPrimary (citable) accession number: P0C0I9
    Secondary accession number(s): Q48W04, Q54713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3