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P0C0I9

- HASC1_STRP1

UniProt

P0C0I9 - HASC1_STRP1

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Protein
UTP--glucose-1-phosphate uridylyltransferase 1
Gene
hasC1, hasC, SPy_2202, M5005_Spy1853
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
  2. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1796-MONOMER.
SPYO293653:GHFC-1934-MONOMER.
UniPathwayiUPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1 (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
UDP-glucose pyrophosphorylase 1
Short name:
UDPGP 1
Uridine diphosphoglucose pyrophosphorylase 1
Gene namesi
Name:hasC1
Synonyms:hasC
Ordered Locus Names:SPy_2202, M5005_Spy1853
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304UTP--glucose-1-phosphate uridylyltransferase 1
PRO_0000201368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_2202.

Structurei

3D structure databases

ProteinModelPortaliP0C0I9.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Phylogenomic databases

HOGENOMiHOG000283477.
KOiK00963.
OMAiSRINIHY.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0I9-1 [UniParc]FASTAAdd to Basket

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MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
EEILVVTGKA KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF 100
IRQSHPRGLG DAVLQAKAFV GNEPFVVMLG DDLMDITNAS AKPLTKQLME 150
DYDKTHASTI AVMKVPHEDV SSYGVIAPQG KAVKGLYSVD TFVEKPQPED 200
APSDLAIIGR YLLTPEIFGI LERQTPGAGN EVQLTDAIDT LNKTQRVFAR 250
EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP 300
THSK 304
Length:304
Mass (Da):33,650
Last modified:September 13, 2005 - v1
Checksum:i48149D764B5E2BEE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34830.1.
CP000017 Genomic DNA. Translation: AAZ52471.1.
RefSeqiNP_270109.1. NC_002737.1.
YP_283216.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34830; AAK34830; SPy_2202.
AAZ52471; AAZ52471; M5005_Spy1853.
GeneIDi3571025.
901878.
KEGGispy:SPy_2202.
spz:M5005_Spy_1853.
PATRICi19717727. VBIStrPyo79812_1907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34830.1 .
CP000017 Genomic DNA. Translation: AAZ52471.1 .
RefSeqi NP_270109.1. NC_002737.1.
YP_283216.1. NC_007297.1.

3D structure databases

ProteinModelPortali P0C0I9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160490.SPy_2202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34830 ; AAK34830 ; SPy_2202 .
AAZ52471 ; AAZ52471 ; M5005_Spy1853 .
GeneIDi 3571025.
901878.
KEGGi spy:SPy_2202.
spz:M5005_Spy_1853.
PATRICi 19717727. VBIStrPyo79812_1907.

Phylogenomic databases

HOGENOMi HOG000283477.
KOi K00963.
OMAi SRINIHY.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00215 .
BioCyci SPYO160490:GJ81-1796-MONOMER.
SPYO293653:GHFC-1934-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiHASC1_STRP1
AccessioniPrimary (citable) accession number: P0C0I9
Secondary accession number(s): Q48W04, Q54713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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