Reviewed, UniProtKB/Swiss-Prot P0C0I9 (HASC1_STRP1)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 1
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase 1
      Short name=UDPGP 1
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
    Uridine diphosphoglucose pyrophosphorylase 1

Gene names

Name:	hasC1
Synonyms:	hasC
Ordered Locus Names:	SPy_2202, M5005_Spy1853

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000201368

Sequences

	Sequence		Length	Mass (Da)
	P0C0I9-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 48149D764B5E2BEE	FASTA	304	33,650
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFGI LERQTPGAGN EVQLTDAIDT 250 260 270 280 290 300 LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP THSK

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK34830.1. CP000017 Genomic DNA. Translation: AAZ52471.1.
RefSeq	NP_270109.1. YP_283216.1.
3D structure databases
SMR	P0C0I9. Positions 2-287.
ModBase	Search...
Genome annotation databases
GeneID	3571025. 901878.
GenomeReviews	Gene locus SPy_2202 in contig AE004092_GR. Gene locus M5005_Spy1853 in contig CP000017_GR.
KEGG	spy:SPy_2202. spz:M5005_Spy_1853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG688195.
OMA	DINICFI.
Enzyme and pathway databases
BioCyc	SPYO160490:SPY2202-MONOMER. SPYO293653:M5005_SPY1853-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC1_STRP1

Accession

Primary (citable) accession number: P0C0I9
Secondary accession number(s): Q48W04, Q54713

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)