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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

hasC

Organism
Streptococcus pyogenes
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway:inucleotide-sugar metabolism

This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:hasC
OrganismiStreptococcus pyogenes
Taxonomic identifieri1314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304UTP--glucose-1-phosphate uridylyltransferasePRO_0000201367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_2202.

Structurei

3D structure databases

ProteinModelPortaliP0C0I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

P0C0I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI
60 70 80 90 100
EEILVVTGKA KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF
110 120 130 140 150
IRQSHPRGLG DAVLQAKAFV GNEPFVVMLG DDLMDITNAS AKPLTKQLME
160 170 180 190 200
DYDKTHASTI AVMKVPHEDV SSYGVIAPQG KAVKGLYSVD TFVEKPQPED
210 220 230 240 250
APSDLAIIGR YLLTPEIFDI LERQTPGAGN EVQLTDAIDT LNKTQRVFAR
260 270 280 290 300
EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP

THSK
Length:304
Mass (Da):33,708
Last modified:September 13, 2005 - v1
Checksum:i88279E454B5C4413
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33452 Genomic DNA. Translation: AAA91810.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33452 Genomic DNA. Translation: AAA91810.1.

3D structure databases

ProteinModelPortaliP0C0I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_2202.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG1210.

Enzyme and pathway databases

UniPathwayiUPA00215.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity."
    Crater D.L., Dougherty B.A., van de Rijn I.
    J. Biol. Chem. 270:28676-28680(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WF51.

Entry informationi

Entry nameiHASC_STRPY
AccessioniPrimary (citable) accession number: P0C0I8
Secondary accession number(s): Q54713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: June 24, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.