Reviewed, UniProtKB/Swiss-Prot P0C0I8 (HASC_STRPY)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:

hasC

Organism

Streptococcus pyogenes

Taxonomic identifier

1314 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000201367

Sequences

	Sequence		Length	Mass (Da)
	P0C0I8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 88279E454B5C4413	FASTA	304	33,708
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQTPGAGN EVQLTDAIDT 250 260 270 280 290 300 LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP THSK

References

[1]

"Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity." Crater D.L., Dougherty B.A., van de Rijn I. J. Biol. Chem. 270:28676-28680(1995) [PubMed: 7499387] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WF51.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33452 Genomic DNA. Translation: AAA91810.1.
3D structure databases
SMR	P0C0I8. Positions 2-287.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.9. 701.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC_STRPY

Accession

Primary (citable) accession number: P0C0I8
Secondary accession number(s): Q54713

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)