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P0C0I1

- SODM_STRP1

UniProt

P0C0I1 - SODM_STRP1

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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 manganese ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271ManganeseBy similarity
Metal bindingi81 – 811ManganeseBy similarity
Metal bindingi163 – 1631ManganeseBy similarity
Metal bindingi167 – 1671ManganeseBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1156-MONOMER.
SPYO293653:GHFC-1204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
Ordered Locus Names:SPy_1406, M5005_Spy1145
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 201200Superoxide dismutase [Mn]PRO_0000160101Add
BLAST

Proteomic databases

PaxDbiP0C0I1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_1406.

Structurei

3D structure databases

ProteinModelPortaliP0C0I1.
SMRiP0C0I1. Positions 5-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
KOiK04564.
OMAiTIFWQIM.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0I1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG
60 70 80 90 100
ENLEELLADV TKIPEDIRQT LINNGGGHLN HALFWELLSP EKQDVTPDVA
110 120 130 140 150
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT
160 170 180 190 200
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIVNW KKVSELYQAA

K
Length:201
Mass (Da):22,683
Last modified:January 23, 2007 - v2
Checksum:i77105B35287F536F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34221.1.
CP000017 Genomic DNA. Translation: AAZ51763.1.
RefSeqiNP_269500.1. NC_002737.1.
YP_282508.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34221; AAK34221; SPy_1406.
AAZ51763; AAZ51763; M5005_Spy1145.
GeneIDi3571769.
901469.
KEGGispy:SPy_1406.
spz:M5005_Spy_1145.
PATRICi19716322. VBIStrPyo79812_1225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34221.1 .
CP000017 Genomic DNA. Translation: AAZ51763.1 .
RefSeqi NP_269500.1. NC_002737.1.
YP_282508.1. NC_007297.1.

3D structure databases

ProteinModelPortali P0C0I1.
SMRi P0C0I1. Positions 5-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1406.

Proteomic databases

PaxDbi P0C0I1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34221 ; AAK34221 ; SPy_1406 .
AAZ51763 ; AAZ51763 ; M5005_Spy1145 .
GeneIDi 3571769.
901469.
KEGGi spy:SPy_1406.
spz:M5005_Spy_1145.
PATRICi 19716322. VBIStrPyo79812_1225.

Phylogenomic databases

eggNOGi COG0605.
HOGENOMi HOG000013583.
KOi K04564.
OMAi TIFWQIM.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-1156-MONOMER.
SPYO293653:GHFC-1204-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiSODM_STRP1
AccessioniPrimary (citable) accession number: P0C0I1
Secondary accession number(s): O54264
, P77957, Q48Y12, Q59941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3