P0C0I1 (SODM_STRP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn]
EC=1.15.1.1

Gene names

Name:	sodA
Synonyms:	sod
Ordered Locus Names:	SPy_1406, M5005_Spy1145

Organism

Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]

Taxonomic identifier

301447 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 manganese ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.
Caution	Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.

Ontologies

Keywords
Cellular component	Secreted
Ligand	Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 201	200	Superoxide dismutase [Mn]		PRO_0000160101
Sites
	Metal binding	27	1	Manganese By similarity
	Metal binding	81	1	Manganese By similarity
	Metal binding	163	1	Manganese By similarity
	Metal binding	167	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C0I1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 77105B35287F536F	FASTA	201	22,683
	10 20 30 40 50 60 MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG ENLEELLADV 70 80 90 100 110 120 TKIPEDIRQT LINNGGGHLN HALFWELLSP EKQDVTPDVA QAIDDAFGSF DAFKEQFTAA 130 140 150 160 170 180 ATGRFGSGWA WLVVNKEGQL EITSTANQDT PISEGKKPIL ALDVWEHAYY LNYRNVRPNY 190 200 IKAFFEIVNW KKVSELYQAA K

References

[1]

"Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E. Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1.

[2]

"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004092 Genomic DNA. Translation: AAK34221.1. CP000017 Genomic DNA. Translation: AAZ51763.1.
RefSeq	NP_269500.1. NC_002737.1. YP_282508.1. NC_007297.1.
3D structure databases
ProteinModelPortal	P0C0I1.
SMR	P0C0I1. Positions 5-197.
ModBase	Search...
Protein-protein interaction databases
STRING	160490.SPy_1406.
Proteomic databases
PaxDb	P0C0I1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK34221; AAK34221; SPy_1406. AAZ51763; AAZ51763; M5005_Spy1145.
GeneID	3571769. 901469.
KEGG	spy:SPy_1406. spz:M5005_Spy_1145.
PATRIC	19716322. VBIStrPyo79812_1225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0605.
HOGENOM	HOG000013583.
KO	K04564.
OMA	ETMTIHH.
ProtClustDB	CLSK877206.
Family and domain databases
InterPro	IPR001189. Mn/Fe_SOD. IPR019833. Mn/Fe_SOD_BS. IPR019832. Mn/Fe_SOD_C. IPR019831. Mn/Fe_SOD_N. [Graphical view]
PANTHER	PTHR11404. PTHR11404. 1 hit.
Pfam	PF02777. Sod_Fe_C. 1 hit. PF00081. Sod_Fe_N. 1 hit. [Graphical view]
PIRSF	PIRSF000349. SODismutase. 1 hit.
PRINTS	PR01703. MNSODISMTASE.
SUPFAM	SSF46609. SODismutase. 1 hit. SSF54719. SODismutase. 1 hit.
PROSITE	PS00088. SOD_MN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODM_STRP1

Accession

Primary (citable) accession number: P0C0I1
Secondary accession number(s): O54264 , P77957, Q48Y12, Q59941

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program