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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27ManganeseBy similarity1
Metal bindingi81ManganeseBy similarity1
Metal bindingi163ManganeseBy similarity1
Metal bindingi167ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
Ordered Locus Names:SPy_1406, M5005_Spy1145
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001601012 – 201Superoxide dismutase [Mn]Add BLAST200

Proteomic databases

PaxDbiP0C0I1
PRIDEiP0C0I1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_1406

Structurei

3D structure databases

ProteinModelPortaliP0C0I1
SMRiP0C0I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013583
KOiK04564
OMAiKWGSFDK

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG
60 70 80 90 100
ENLEELLADV TKIPEDIRQT LINNGGGHLN HALFWELLSP EKQDVTPDVA
110 120 130 140 150
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT
160 170 180 190 200
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIVNW KKVSELYQAA

K
Length:201
Mass (Da):22,683
Last modified:January 23, 2007 - v2
Checksum:i77105B35287F536F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK34221.1
CP000017 Genomic DNA Translation: AAZ51763.1
RefSeqiNP_269500.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK34221; AAK34221; SPy_1406
AAZ51763; AAZ51763; M5005_Spy1145
GeneIDi901469
KEGGispy:SPy_1406
spz:M5005_Spy1145
PATRICifig|160490.10.peg.1225

Entry informationi

Entry nameiSODM_STRP1
AccessioniPrimary (citable) accession number: P0C0I1
Secondary accession number(s): O54264
, P77957, Q48Y12, Q59941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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