Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0C0I1

- SODM_STRP1

UniProt

P0C0I1 - SODM_STRP1

Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271ManganeseBy similarity
    Metal bindingi81 – 811ManganeseBy similarity
    Metal bindingi163 – 1631ManganeseBy similarity
    Metal bindingi167 – 1671ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-1156-MONOMER.
    SPYO293653:GHFC-1204-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] (EC:1.15.1.1)
    Gene namesi
    Name:sodA
    Synonyms:sod
    Ordered Locus Names:SPy_1406, M5005_Spy1145
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 201200Superoxide dismutase [Mn]PRO_0000160101Add
    BLAST

    Proteomic databases

    PaxDbiP0C0I1.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi160490.SPy_1406.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C0I1.
    SMRiP0C0I1. Positions 5-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiTIFWQIM.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0C0I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG    50
    ENLEELLADV TKIPEDIRQT LINNGGGHLN HALFWELLSP EKQDVTPDVA 100
    QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT 150
    PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIVNW KKVSELYQAA 200
    K 201
    Length:201
    Mass (Da):22,683
    Last modified:January 23, 2007 - v2
    Checksum:i77105B35287F536F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34221.1.
    CP000017 Genomic DNA. Translation: AAZ51763.1.
    RefSeqiNP_269500.1. NC_002737.1.
    YP_282508.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK34221; AAK34221; SPy_1406.
    AAZ51763; AAZ51763; M5005_Spy1145.
    GeneIDi3571769.
    901469.
    KEGGispy:SPy_1406.
    spz:M5005_Spy_1145.
    PATRICi19716322. VBIStrPyo79812_1225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004092 Genomic DNA. Translation: AAK34221.1 .
    CP000017 Genomic DNA. Translation: AAZ51763.1 .
    RefSeqi NP_269500.1. NC_002737.1.
    YP_282508.1. NC_007297.1.

    3D structure databases

    ProteinModelPortali P0C0I1.
    SMRi P0C0I1. Positions 5-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_1406.

    Proteomic databases

    PaxDbi P0C0I1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK34221 ; AAK34221 ; SPy_1406 .
    AAZ51763 ; AAZ51763 ; M5005_Spy1145 .
    GeneIDi 3571769.
    901469.
    KEGGi spy:SPy_1406.
    spz:M5005_Spy_1145.
    PATRICi 19716322. VBIStrPyo79812_1225.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi TIFWQIM.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-1156-MONOMER.
    SPYO293653:GHFC-1204-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiSODM_STRP1
    AccessioniPrimary (citable) accession number: P0C0I1
    Secondary accession number(s): O54264
    , P77957, Q48Y12, Q59941
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3