SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C0I1

- SODM_STRP1

UniProt

P0C0I1 - SODM_STRP1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Superoxide dismutase [Mn]
Gene
sodA, sod, SPy_1406, M5005_Spy1145
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems By similarity.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese By similarity
Metal bindingi81 – 811Manganese By similarity
Metal bindingi163 – 1631Manganese By similarity
Metal bindingi167 – 1671Manganese By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-1156-MONOMER.
SPYO293653:GHFC-1204-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sod
Ordered Locus Names:SPy_1406, M5005_Spy1145
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 201200Superoxide dismutase [Mn]
PRO_0000160101Add
BLAST

Proteomic databases

PaxDbiP0C0I1.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi160490.SPy_1406.

Structurei

3D structure databases

ProteinModelPortaliP0C0I1.
SMRiP0C0I1. Positions 5-197.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
KOiK04564.
OMAiTIFWQIM.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0I1-1 [UniParc]FASTAAdd to Basket

« Hide

MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG    50
ENLEELLADV TKIPEDIRQT LINNGGGHLN HALFWELLSP EKQDVTPDVA 100
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT 150
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIVNW KKVSELYQAA 200
K 201
Length:201
Mass (Da):22,683
Last modified:January 23, 2007 - v2
Checksum:i77105B35287F536F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34221.1.
CP000017 Genomic DNA. Translation: AAZ51763.1.
RefSeqiNP_269500.1. NC_002737.1.
YP_282508.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK34221; AAK34221; SPy_1406.
AAZ51763; AAZ51763; M5005_Spy1145.
GeneIDi3571769.
901469.
KEGGispy:SPy_1406.
spz:M5005_Spy_1145.
PATRICi19716322. VBIStrPyo79812_1225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK34221.1 .
CP000017 Genomic DNA. Translation: AAZ51763.1 .
RefSeqi NP_269500.1. NC_002737.1.
YP_282508.1. NC_007297.1.

3D structure databases

ProteinModelPortali P0C0I1.
SMRi P0C0I1. Positions 5-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1406.

Proteomic databases

PaxDbi P0C0I1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK34221 ; AAK34221 ; SPy_1406 .
AAZ51763 ; AAZ51763 ; M5005_Spy1145 .
GeneIDi 3571769.
901469.
KEGGi spy:SPy_1406.
spz:M5005_Spy_1145.
PATRICi 19716322. VBIStrPyo79812_1225.

Phylogenomic databases

eggNOGi COG0605.
HOGENOMi HOG000013583.
KOi K04564.
OMAi TIFWQIM.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-1156-MONOMER.
SPYO293653:GHFC-1204-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiSODM_STRP1
AccessioniPrimary (citable) accession number: P0C0I1
Secondary accession number(s): O54264
, P77957, Q48Y12, Q59941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi