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Protein

Dihydropteroate synthase

Gene

folP

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19MagnesiumBy similarity1
Binding sitei596-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei936-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1126-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1766-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2126-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKP0C0G1
UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Ordered Locus Names:SPy_1098, M5005_Spy0822
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682331 – 266Dihydropteroate synthaseAdd BLAST266

Proteomic databases

PaxDbiP0C0G1
PRIDEiP0C0G1

Interactioni

Subunit structurei

Homodimer or homotrimer.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_1098

Structurei

3D structure databases

ProteinModelPortaliP0C0G1
SMRiP0C0G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 260Pterin-bindingPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 2506-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217509
KOiK00796
OMAiWAVRVHD

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGKFVIEG NAAIMGILNV TPDSFSDGGS YTTVQKALDH VEQMIADGAK
60 70 80 90 100
IIDVGGESTR PGCQFVSATD EIDRVVPVIK AIKENYDILI SIDTYKTETA
110 120 130 140 150
RAALEAGADI LNDVWAGLYD GQMFALAAEY DAPIILMHNQ DEEVYQEVTQ
160 170 180 190 200
DVCDFLGNRA QAALDAGVPK NNIWVDPGFG FAKSVQQNTE LLKGLDRVCQ
210 220 230 240 250
LGYPVLFGIS RKRVVDALLG GNTKAKERDG ATAALSAYAL GKGCQIVRVH
260
DVKANQDIVA VLSQLM
Length:266
Mass (Da):28,642
Last modified:September 13, 2005 - v1
Checksum:iB04D0C553B5BAB22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA Translation: AAK33976.1
CP000017 Genomic DNA Translation: AAZ51440.1
RefSeqiNP_269255.1, NC_002737.2

Genome annotation databases

EnsemblBacteriaiAAK33976; AAK33976; SPy_1098
AAZ51440; AAZ51440; M5005_Spy0822
GeneIDi901219
KEGGispy:SPy_1098
spz:M5005_Spy0822
PATRICifig|160490.10.peg.954

Similar proteinsi

Entry informationi

Entry nameiDHPS_STRP1
AccessioniPrimary (citable) accession number: P0C0G1
Secondary accession number(s): O33724, Q48YY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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