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P0C0G1

- DHPS_STRP1

UniProt

P0C0G1 - DHPS_STRP1

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Protein

Dihydropteroate synthase

Gene

folP

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.By similarity

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191MagnesiumBy similarity
Binding sitei27 – 271SubstrateBy similarity
Binding sitei93 – 931SubstrateBy similarity
Binding sitei112 – 1121SubstrateBy similarity
Binding sitei176 – 1761SubstrateBy similarity
Binding sitei212 – 2121SubstrateBy similarity
Binding sitei248 – 2481SubstrateBy similarity
Binding sitei250 – 2501SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-906-MONOMER.
SPYO293653:GHFC-881-MONOMER.
SABIO-RKP0C0G1.
UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Ordered Locus Names:SPy_1098, M5005_Spy0822
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Dihydropteroate synthasePRO_0000168233Add
BLAST

Proteomic databases

PaxDbiP0C0G1.

Interactioni

Subunit structurei

Homodimer or homotrimer.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_1098.

Structurei

3D structure databases

ProteinModelPortaliP0C0G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 260249Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 602Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217509.
KOiK00796.
OMAiDKGSPDK.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIGKFVIEG NAAIMGILNV TPDSFSDGGS YTTVQKALDH VEQMIADGAK
60 70 80 90 100
IIDVGGESTR PGCQFVSATD EIDRVVPVIK AIKENYDILI SIDTYKTETA
110 120 130 140 150
RAALEAGADI LNDVWAGLYD GQMFALAAEY DAPIILMHNQ DEEVYQEVTQ
160 170 180 190 200
DVCDFLGNRA QAALDAGVPK NNIWVDPGFG FAKSVQQNTE LLKGLDRVCQ
210 220 230 240 250
LGYPVLFGIS RKRVVDALLG GNTKAKERDG ATAALSAYAL GKGCQIVRVH
260
DVKANQDIVA VLSQLM
Length:266
Mass (Da):28,642
Last modified:September 13, 2005 - v1
Checksum:iB04D0C553B5BAB22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33976.1.
CP000017 Genomic DNA. Translation: AAZ51440.1.
RefSeqiNP_269255.1. NC_002737.1.
YP_282185.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33976; AAK33976; SPy_1098.
AAZ51440; AAZ51440; M5005_Spy0822.
GeneIDi3572070.
901219.
KEGGispy:SPy_1098.
spz:M5005_Spy_0822.
PATRICi19715779. VBIStrPyo79812_0954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33976.1 .
CP000017 Genomic DNA. Translation: AAZ51440.1 .
RefSeqi NP_269255.1. NC_002737.1.
YP_282185.1. NC_007297.1.

3D structure databases

ProteinModelPortali P0C0G1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1098.

Proteomic databases

PaxDbi P0C0G1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33976 ; AAK33976 ; SPy_1098 .
AAZ51440 ; AAZ51440 ; M5005_Spy0822 .
GeneIDi 3572070.
901219.
KEGGi spy:SPy_1098.
spz:M5005_Spy_0822.
PATRICi 19715779. VBIStrPyo79812_0954.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217509.
KOi K00796.
OMAi DKGSPDK.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .
BioCyci SPYO160490:GJ81-906-MONOMER.
SPYO293653:GHFC-881-MONOMER.
SABIO-RK P0C0G1.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiDHPS_STRP1
AccessioniPrimary (citable) accession number: P0C0G1
Secondary accession number(s): O33724, Q48YY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3