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P0C0G0 (DHPS_STRPY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropteroate synthase

Short name=DHPS
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene names
Name:folP
OrganismStreptococcus pyogenes
Taxonomic identifier1314 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Subunit structure

Homodimer or homotrimer.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Dihydropteroate synthase
PRO_0000168232

Regions

Domain12 – 260249Pterin-binding
Region59 – 602Substrate binding By similarity

Sites

Metal binding191Magnesium By similarity
Binding site271Substrate By similarity
Binding site931Substrate By similarity
Binding site1121Substrate By similarity
Binding site1761Substrate By similarity
Binding site2121Substrate By similarity
Binding site2481Substrate By similarity
Binding site2501Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0C0G0 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: C6BC402F07CFDF36

FASTA26628,515
        10         20         30         40         50         60 
MKIGKFVIDG NAAIMGILNV TPDSFSDGGS YTTVQKVLQQ VDQLIAGGAK IIDVGGESTR 

        70         80         90        100        110        120 
PGYQFVSAAD EIERVVPMIK AIKAKYDVLI SIDTYKTETA RAALEAGADI LNDVRAGLYD 

       130        140        150        160        170        180 
GEMLALAAEY DVPIILMHNQ KEEVYQDVTQ DVCDFLSARA QAAIDAGVPK DNIWIDPGFG 

       190        200        210        220        230        240 
FPKSVQHNME LLKGLDHVCQ LGYPVLFGIS RKGVVDALLG GNTKAKERDG ATAALSAYAL 

       250        260 
GKGCQLVRVH DVKANQEIVA VLSQLM 

« Hide

References

[1]"Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase."
Swedberg G., Ringertz S., Skoeld O.
Antimicrob. Agents Chemother. 42:1062-1067(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: G56.
[2]"Point mutations in the dihydropteroate synthase gene causing sulfonamide resistance."
Swedberg G., Fermer C., Skoeld O.
Adv. Exp. Med. Biol. 338:555-558(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: G56.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ000685 Genomic DNA. Translation: CAA04238.1.

3D structure databases

ProteinModelPortalP0C0G0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP0C0G0.
UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS_STRPY
AccessionPrimary (citable) accession number: P0C0G0
Secondary accession number(s): O33724
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 16, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways