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Protein

Dihydropteroate synthase

Gene

folP

Organism
Streptococcus pyogenes
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP), Dihydropteroate synthase, Dihydropteroate synthase, Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase (folP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19MagnesiumBy similarity1
Binding sitei596-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei936-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1126-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1766-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2126-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKP0C0G0
UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
OrganismiStreptococcus pyogenes
Taxonomic identifieri1314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682321 – 266Dihydropteroate synthaseAdd BLAST266

Proteomic databases

PRIDEiP0C0G0

Interactioni

Subunit structurei

Homodimer or homotrimer.

Structurei

3D structure databases

ProteinModelPortaliP0C0G0
SMRiP0C0G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 260Pterin-bindingPROSITE-ProRule annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni248 – 2506-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P0C0G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGKFVIDG NAAIMGILNV TPDSFSDGGS YTTVQKVLQQ VDQLIAGGAK
60 70 80 90 100
IIDVGGESTR PGYQFVSAAD EIERVVPMIK AIKAKYDVLI SIDTYKTETA
110 120 130 140 150
RAALEAGADI LNDVRAGLYD GEMLALAAEY DVPIILMHNQ KEEVYQDVTQ
160 170 180 190 200
DVCDFLSARA QAAIDAGVPK DNIWIDPGFG FPKSVQHNME LLKGLDHVCQ
210 220 230 240 250
LGYPVLFGIS RKGVVDALLG GNTKAKERDG ATAALSAYAL GKGCQLVRVH
260
DVKANQEIVA VLSQLM
Length:266
Mass (Da):28,515
Last modified:September 13, 2005 - v1
Checksum:iC6BC402F07CFDF36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000685 Genomic DNA Translation: CAA04238.1

Similar proteinsi

Entry informationi

Entry nameiDHPS_STRPY
AccessioniPrimary (citable) accession number: P0C0G0
Secondary accession number(s): O33724
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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