Reviewed,
UniProtKB/Swiss-Prot P0C0F5 (UDG_STRP1)
Last modified
July 13, 2010.
Version 43.
History...
Clusters with 100%,
90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 | ||||
| Gene names |
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| Organism | Streptococcus pyogenes serotype M1 [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 301447 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
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Protein attributesHide
| Sequence length | 402 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
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General annotation (Comments)Hide
| Function | Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis By similarity. |
| Catalytic activity | UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
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OntologiesHide
| Keywords | |
|---|---|
| Biological process | Capsule biogenesis/degradation |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
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SequencesHide
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ReferencesHide
| [1] | "Complete genome sequence of an M1 strain of Streptococcus pyogenes." Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. McLaughlin R.E.Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed: 11296296] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700294 / SF370 / Serotype M1. |
| [2] | "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events." Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M. J. Infect. Dis. 192:771-782(2005) [PubMed: 16088826] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-947 / MGAS5005 / Serotype M1. |
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Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE004092 Genomic DNA. Translation: AAK34829.1. CP000017 Genomic DNA. Translation: AAZ52470.1. |
| RefSeq | NP_270108.1. YP_283215.1. |
3D structure databases | |
| SMR | P0C0F5. Positions 1-402. |
| ModBase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTRT00000000653; EBSTRP00000000653; EBSTRG00000000653. EBSTRT00000028248; EBSTRP00000027266; EBSTRG00000028248. |
| GeneID | 3571024. 901876. |
| GenomeReviews | Gene locus SPy_2201 in contig AE004092_GR. Gene locus M5005_Spy1852 in contig CP000017_GR. |
| KEGG | spy:SPy_2201. spz:M5005_Spy_1852. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG400967. |
| OMA | SHDDRIG. |
| ProtClustDB | CLSK699009. |
Enzyme and pathway databases | |
| BioCyc | SPYO160490:SPY2201-MONOMER. SPYO293653:M5005_SPY1852-MONOMER. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C_like. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000124. UDPglc_GDPman_dh. 1 hit. |
| SUPFAM | SSF48179. 6DGDH_C_like. 1 hit. SSF52413. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| TIGRFAMs | TIGR03026. NDP-sugDHase. 1 hit. |
| ProtoNet | Search... |
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Entry informationHide
| Entry name | UDG_STRP1 | ||||||||
| Accession | Primary (citable) accession number: P0C0F5 Secondary accession number(s): Q07172, Q48W05 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
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Relevant documentsHide
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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