P0C0C9 (OTCC_STRPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:

arcB

Organism

Streptococcus pyogenes

Taxonomic identifier

1314 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	107 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – ›107	›106	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113037
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
Sites
	Site	32	1	Important for structural integrity By similarity
Experimental info
	Non-terminal residue	107	1

Sequences

	Sequence		Length	Mass (Da)
	P0C0C9 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B6CC2FF49D77D330	FASTA	107	12,079
	10 20 30 40 50 60 MTQVFQGRSF LAEKDFTRAE LEYLIDFSAH LKDLKKRGVP HHYLEGKNIA LLFEKTSTRT 70 80 90 100 RAAFTTAAID LGAHPEYLGA NDIQLGKKES TEDTAKVLGR MFDGIEF

References

[1]	"Cloning and expression of the antitumor glycoprotein gene of Streptococcus pyogenes Su in Escherichia coli." Kanaoka M., Kawanaka C., Negoro T., Fukita Y., Taya K., Agui H. Agric. Biol. Chem. 51:2641-2648(1987) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 21060 / Su / DSM 2072.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13790 Genomic DNA. Translation: BAA02940.1.
PIR	PE0009.
3D structure databases
ProteinModelPortal	P0C0C9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR002292. Orn/put_carbamltrans. [Graphical view]
Pfam	PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_STRPY

Accession

Primary (citable) accession number: P0C0C9
Secondary accession number(s): P16964

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program