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P0C0C2

- GCH1_STRP1

UniProt

P0C0C2 - GCH1_STRP1

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Protein
GTP cyclohydrolase 1
Gene
folE, SPy_1097, M5005_Spy0821
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Zinc By similarity
Metal bindingi86 – 861Zinc By similarity
Metal bindingi155 – 1551Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-905-MONOMER.
SPYO293653:GHFC-880-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:SPy_1097, M5005_Spy0821
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194GTP cyclohydrolase 1UniRule annotation
PRO_0000119452Add
BLAST

Proteomic databases

PaxDbiP0C0C2.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Protein-protein interaction databases

STRINGi160490.SPy_1097.

Structurei

3D structure databases

ProteinModelPortaliP0C0C2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
HOGENOMiHOG000221222.
KOiK01495.
OMAiKRTYDEE.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0C2-1 [UniParc]FASTAAdd to Basket

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MKRERLMSIN KEKAEAAIYQ FLEAIGENPN REGLLDTPKR VAKMYAEMFL    50
GLGKDPKEEF TAVFKEQHED VVIVKDISFY SICEHHLVPF YGKAHIAYLP 100
SDGRVTGLSK LARAVEVASK RPQLQERLTS QIADALVEAL NPKGTLVMVE 150
AEHMCMTMRG IKKPGSKTIT TTARGLYKES RAERQEVISL MTKD 194
Length:194
Mass (Da):21,871
Last modified:September 13, 2005 - v1
Checksum:i03675C972EED7A0F
GO

Sequence cautioni

The sequence AAK33975.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAZ51439.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33975.1. Different initiation.
CP000017 Genomic DNA. Translation: AAZ51439.1. Different initiation.
RefSeqiNP_269254.1. NC_002737.1.
YP_282184.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33975; AAK33975; SPy_1097.
AAZ51439; AAZ51439; M5005_Spy0821.
GeneIDi3572069.
901218.
KEGGispy:SPy_1097.
spz:M5005_Spy_0821.
PATRICi19715777. VBIStrPyo79812_0953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004092 Genomic DNA. Translation: AAK33975.1 . Different initiation.
CP000017 Genomic DNA. Translation: AAZ51439.1 . Different initiation.
RefSeqi NP_269254.1. NC_002737.1.
YP_282184.1. NC_007297.1.

3D structure databases

ProteinModelPortali P0C0C2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 160490.SPy_1097.

Proteomic databases

PaxDbi P0C0C2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33975 ; AAK33975 ; SPy_1097 .
AAZ51439 ; AAZ51439 ; M5005_Spy0821 .
GeneIDi 3572069.
901218.
KEGGi spy:SPy_1097.
spz:M5005_Spy_0821.
PATRICi 19715777. VBIStrPyo79812_0953.

Phylogenomic databases

eggNOGi COG0302.
HOGENOMi HOG000221222.
KOi K01495.
OMAi KRTYDEE.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci SPYO160490:GJ81-905-MONOMER.
SPYO293653:GHFC-880-MONOMER.

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  2. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiGCH1_STRP1
AccessioniPrimary (citable) accession number: P0C0C2
Secondary accession number(s): O33723
, P0A3E8, Q48YY3, Q8P153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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