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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi155ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:SPy_1097, M5005_Spy0821
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001194521 – 194GTP cyclohydrolase 1Add BLAST194

Proteomic databases

PaxDbiP0C0C2.
PRIDEiP0C0C2.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi160490.SPy_1097.

Structurei

3D structure databases

ProteinModelPortaliP0C0C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRERLMSIN KEKAEAAIYQ FLEAIGENPN REGLLDTPKR VAKMYAEMFL
60 70 80 90 100
GLGKDPKEEF TAVFKEQHED VVIVKDISFY SICEHHLVPF YGKAHIAYLP
110 120 130 140 150
SDGRVTGLSK LARAVEVASK RPQLQERLTS QIADALVEAL NPKGTLVMVE
160 170 180 190
AEHMCMTMRG IKKPGSKTIT TTARGLYKES RAERQEVISL MTKD
Length:194
Mass (Da):21,871
Last modified:September 13, 2005 - v1
Checksum:i03675C972EED7A0F
GO

Sequence cautioni

The sequence AAK33975 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAZ51439 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33975.1. Different initiation.
CP000017 Genomic DNA. Translation: AAZ51439.1. Different initiation.
RefSeqiNP_269254.1. NC_002737.2.

Genome annotation databases

EnsemblBacteriaiAAK33975; AAK33975; SPy_1097.
AAZ51439; AAZ51439; M5005_Spy0821.
GeneIDi901218.
KEGGispy:SPy_1097.
spz:M5005_Spy0821.
PATRICi19715777. VBIStrPyo79812_0953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004092 Genomic DNA. Translation: AAK33975.1. Different initiation.
CP000017 Genomic DNA. Translation: AAZ51439.1. Different initiation.
RefSeqiNP_269254.1. NC_002737.2.

3D structure databases

ProteinModelPortaliP0C0C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_1097.

Proteomic databases

PaxDbiP0C0C2.
PRIDEiP0C0C2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK33975; AAK33975; SPy_1097.
AAZ51439; AAZ51439; M5005_Spy0821.
GeneIDi901218.
KEGGispy:SPy_1097.
spz:M5005_Spy0821.
PATRICi19715777. VBIStrPyo79812_0953.

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiVEGEHLC.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCH1_STRP1
AccessioniPrimary (citable) accession number: P0C0C2
Secondary accession number(s): O33723
, P0A3E8, Q48YY3, Q8P153
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.