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Protein

Small VCP/p97-interacting protein

Gene

Svip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Small VCP/p97-interacting protein
Gene namesi
Name:Svip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1565432. Svip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Small VCP/p97-interacting proteinPRO_0000072339Add
BLAST

Proteomic databases

PaxDbiP0C0A9.
PRIDEiP0C0A9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevisibleiP0C0A9. RN.

Interactioni

Subunit structurei

Interacts with VCP.By similarity1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052878.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 3313VCP/p97-interacting motif (VIM)By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SVIP family.Curated

Phylogenomic databases

eggNOGiNOG70810.
GeneTreeiENSGT00390000007067.
HOGENOMiHOG000122415.
HOVERGENiHBG094009.
InParanoidiP0C0A9.
KOiK14014.
OrthoDBiEOG7VQJHF.
PhylomeDBiP0C0A9.

Sequencei

Sequence statusi: Complete.

P0C0A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLCFPCPAE SAPPSPSPEE KRAKLAEAAE RRQKEAASRG ILDIQSVEAK
60 70
KKKKEQLEKQ METSGPPAGG LRWTVS
Length:76
Mass (Da):8,248
Last modified:August 30, 2005 - v1
Checksum:i485974815DBFD4FC
GO

Sequence databases

RefSeqiNP_001258013.1. NM_001271084.1.
UniGeneiRn.77399.

Genome annotation databases

EnsembliENSRNOT00000056024; ENSRNOP00000052878; ENSRNOG00000037137.
GeneIDi499157.
KEGGirno:499157.
UCSCiRGD:1565432. rat.

Cross-referencesi

Sequence databases

RefSeqiNP_001258013.1. NM_001271084.1.
UniGeneiRn.77399.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052878.

Proteomic databases

PaxDbiP0C0A9.
PRIDEiP0C0A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056024; ENSRNOP00000052878; ENSRNOG00000037137.
GeneIDi499157.
KEGGirno:499157.
UCSCiRGD:1565432. rat.

Organism-specific databases

CTDi258010.
RGDi1565432. Svip.

Phylogenomic databases

eggNOGiNOG70810.
GeneTreeiENSGT00390000007067.
HOGENOMiHOG000122415.
HOVERGENiHBG094009.
InParanoidiP0C0A9.
KOiK14014.
OrthoDBiEOG7VQJHF.
PhylomeDBiP0C0A9.

Miscellaneous databases

NextBioi702037.
PROiP0C0A9.

Gene expression databases

GenevisibleiP0C0A9. RN.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation."
    Nagahama M., Suzuki M., Hamada Y., Hatsuzawa K., Tani K., Yamamoto A., Tagaya M.
    Mol. Biol. Cell 14:262-273(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH VCP.
    Tissue: Brain.

Entry informationi

Entry nameiSVIP_RAT
AccessioniPrimary (citable) accession number: P0C0A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.