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Protein

Small VCP/p97-interacting protein

Gene

Svip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Small VCP/p97-interacting protein
Gene namesi
Name:Svip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1565432. Svip.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000723392 – 76Small VCP/p97-interacting proteinAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei46PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP0C0A9.
PRIDEiP0C0A9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000037137.
GenevisibleiP0C0A9. RN.

Interactioni

Subunit structurei

Interacts with VCP.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052878.

Structurei

3D structure databases

SMRiP0C0A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 33VCP/p97-interacting motif (VIM)By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the SVIP family.Curated

Phylogenomic databases

eggNOGiENOG410J4QZ. Eukaryota.
ENOG41117ZU. LUCA.
GeneTreeiENSGT00390000007067.
HOGENOMiHOG000122415.
HOVERGENiHBG094009.
InParanoidiP0C0A9.
KOiK14014.
OMAiEETNLMP.
PhylomeDBiP0C0A9.

Family and domain databases

InterProiView protein in InterPro
IPR031632. SVIP.
PfamiView protein in Pfam
PF15811. SVIP. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD619568. PD619568. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C0A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLCFPCPAE SAPPSPSPEE KRAKLAEAAE RRQKEAASRG ILDIQSVEAK
60 70
KKKKEQLEKQ METSGPPAGG LRWTVS
Length:76
Mass (Da):8,248
Last modified:August 30, 2005 - v1
Checksum:i485974815DBFD4FC
GO

Sequence databases

RefSeqiNP_001258013.1. NM_001271084.1.
UniGeneiRn.77399.

Genome annotation databases

EnsembliENSRNOT00000056024; ENSRNOP00000052878; ENSRNOG00000037137.
GeneIDi499157.
KEGGirno:499157.
UCSCiRGD:1565432. rat.

Similar proteinsi

Entry informationi

Entry nameiSVIP_RAT
AccessioniPrimary (citable) accession number: P0C0A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families