P0C0A9 (SVIP_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small VCP/p97-interacting protein

Gene names

Name:

Svip

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	76 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Overexpression causes the formation of large vacuoles that seemed to be derived from the endoplasmic reticulum. Ref.1
Subunit structure	Interacts with VCP. Ref.1
Subcellular location	Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the SVIP family.

Ontologies

Keywords
Cellular component	Cell membrane Endoplasmic reticulum Golgi apparatus Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell smooth endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 76	76	Small VCP/p97-interacting protein		PRO_0000072339

Sequences

	Sequence		Length	Mass (Da)
	P0C0A9 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 485974815DBFD4FC	FASTA	76	8,248
	10 20 30 40 50 60 MGLCFPCPAE SAPPSPSPEE KRAKLAEAAE RRQKEAASRG ILDIQSVEAK KKKKEQLEKQ 70 METSGPPAGG LRWTVS

References

[1]

"SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation." Nagahama M., Suzuki M., Hamada Y., Hatsuzawa K., Tani K., Yamamoto A., Tagaya M. Mol. Biol. Cell 14:262-273(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH VCP. Tissue: Brain.

Cross-references

Sequence databases
IPI	IPI00561657.
RefSeq	NP_001258013.1. NM_001271084.1.
UniGene	Rn.77399.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000052878.
Proteomic databases
PaxDb	P0C0A9.
PRIDE	P0C0A9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	499157.
KEGG	rno:499157.
UCSC	RGD:1565432. rat.
Organism-specific databases
CTD	258010.
RGD	1565432. Svip.
Phylogenomic databases
eggNOG	NOG70810.
HOGENOM	HOG000122415.
HOVERGEN	HBG094009.
InParanoid	P0C0A9.
KO	K14014.
OMA	QMATSGP.
OrthoDB	EOG4SXNF9.
Gene expression databases
Genevestigator	P0C0A9.
GermOnline	ENSRNOG00000037137. Rattus norvegicus.
Family and domain databases
ProtoNet	Search...
Other
NextBio	702037.

Entry information

Entry name

SVIP_RAT

Accession

Primary (citable) accession number: P0C0A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program