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Protein

FRAS1-related extracellular matrix protein 3

Gene

FREM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extracellular matrix protein which may play a role in cell adhesion.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: BHF-UCL
  • cell communication Source: InterPro

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 3
Gene namesi
Name:FREM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000183090.5
HGNCiHGNC:25172 FREM3
MIMi608946 gene
neXtProtiNX_P0C091

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi166752
OpenTargetsiENSG00000183090

Polymorphism and mutation databases

BioMutaiFREM3
DMDMi357528797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001012731 – 2139FRAS1-related extracellular matrix protein 3Add BLAST2109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1588N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C091
PeptideAtlasiP0C091
PRIDEiP0C091

PTM databases

iPTMnetiP0C091
PhosphoSitePlusiP0C091

Expressioni

Gene expression databases

BgeeiENSG00000183090
CleanExiHS_FREM3
GenevisibleiP0C091 HS

Organism-specific databases

HPAiHPA041641

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332886

Structurei

3D structure databases

ProteinModelPortaliP0C091
SMRiP0C091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati306 – 409CSPG 1PROSITE-ProRule annotationAdd BLAST104
Repeati432 – 522CSPG 2PROSITE-ProRule annotationAdd BLAST91
Repeati543 – 677CSPG 3PROSITE-ProRule annotationAdd BLAST135
Repeati702 – 807CSPG 4PROSITE-ProRule annotationAdd BLAST106
Repeati828 – 920CSPG 5PROSITE-ProRule annotationAdd BLAST93
Repeati948 – 1040CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1069 – 1171CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1192 – 1285CSPG 8PROSITE-ProRule annotationAdd BLAST94
Repeati1306 – 1404CSPG 9PROSITE-ProRule annotationAdd BLAST99
Repeati1425 – 1516CSPG 10PROSITE-ProRule annotationAdd BLAST92
Repeati1536 – 1625CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1659 – 1756CSPG 12PROSITE-ProRule annotationAdd BLAST98
Domaini1764 – 1862Calx-beta 1Add BLAST99
Domaini1875 – 1985Calx-beta 2Add BLAST111
Domaini2000 – 2106Calx-beta 3Add BLAST107

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
KOG3597 Eukaryota
ENOG41112TU LUCA
GeneTreeiENSGT00550000074429
HOGENOMiHOG000007464
HOVERGENiHBG081538
InParanoidiP0C091
OMAiWLSDGKH
OrthoDBiEOG091G02YT
PhylomeDBiP0C091
TreeFamiTF316876

Family and domain databases

Gene3Di2.60.40.2030, 3 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
IPR032833 FREM3
PANTHERiPTHR11878:SF31 PTHR11878:SF31, 1 hit
PfamiView protein in Pfam
PF03160 Calx-beta, 3 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 3 hits
SUPFAMiSSF141072 SSF141072, 3 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASRHPTG TPRQLLVALA CLLLSRPALQ GRASSLGTEP DPALYLPARG
60 70 80 90 100
ALDGTRPDGP SVLIANPGLR VPLGRSLWLD PLRDLVIGVQ PGDRCEVTVL
110 120 130 140 150
DALPRLKGAL SPRRFPCTFG PRQVQYTHFG SHSPGRARVL LQLRYDAPTH
160 170 180 190 200
TLVLPFTLAV DLVFSQLELV TRNRPLVVEK LRSWSRAIDR RVLDFASLKS
210 220 230 240 250
GATATRRCRL TPLPHEDGPL PKYGRLVDAV GAPLPRGKGV DCEAFLRAGV
260 270 280 290 300
RYQHTATSSP NRDYVPMMVE LLGPEGQDAG SAGVLVREHF QLLVRIRGGA
310 320 330 340 350
ENTPPRPSFM ATMMMEVDPL VLTALTPDAL AAEDVESDPG DLVFNILNAP
360 370 380 390 400
THPPGHPGQQ GYVVSTDDPL GLPVSFFTQQ ELRELKIAYQ PPAENSHGER
410 420 430 440 450
LFQLELEVVD GDGAASDPFA FMVTVKSMNT LVPVASHNRG LVLFEGQSRP
460 470 480 490 500
LSSTHSIPIS DKDNLEEVKM AAVRGLRHGQ LVVFGAPAGC KYFTPADLAA
510 520 530 540 550
GRVVYQHDGS NTYSDNIIFR MEDGHHQVDF LFPLTILPVD DEPPMVNTNT
560 570 580 590 600
GLSLTEGQVV QISPFVLSAT DIDSEDSTIH FVLENQPLKG NEEEPQWELA
610 620 630 640 650
PGSSHSGHYL GDLLLQQAEL PLSTEDEDWH YMEKEGLYEK VVTEWLQRDI
660 670 680 690 700
MEGRLFYRHL GPHSPQSVMV QLAFHVQDDH DPPNLSKQHI FTIKVQPVDI
710 720 730 740 750
LSPQLYPGTT LEMTVQEYQL THFQKNFLRY IDQDSDDQNL WYTLLTLPTD
760 770 780 790 800
TDGNHQVRAG EIVLTDSPDT LIMHFTQAQV NQHKVAYQPP QKLGIAPRVV
810 820 830 840 850
QFTYQVEDAA GNSVPGTFTL FLQPVDNQPP EVTNRGFAIL EGGSFNLSSN
860 870 880 890 900
ELHVTDPDTD IDQIVFILVR GPQHGHLQYF KRCMVPGESF MQADVINGSV
910 920 930 940 950
SYQHGRDQTT TSDTFHLEVS DGVHHIPITI PISVHPNVAN RSPRISLRSS
960 970 980 990 1000
SLLDVSIDVL ENKATEITMG VIHGKRKDVG DLMLSFIVKD SPKLGTILVN
1010 1020 1030 1040 1050
GLPTERFTQE DLINGRVAYA HTAGEVGFQK QHDAFSLILS KDSYQWVVGN
1060 1070 1080 1090 1100
SIIEKVQVQV TVLPVDNVGP KVFVGESFIV YEGEKNSLTL QHLHVEDVDT
1110 1120 1130 1140 1150
HQDELLCTVT SQPASGYLEK IASAPGSKMS QSGSPISAFS LRDIQVRHIN
1160 1170 1180 1190 1200
YVQSIHKGVE PQEDQFTFYC SDGINFSPNV FFPIIILPTN DEQPKLFAHE
1210 1220 1230 1240 1250
FKVLEGMSLV IDTQLLNGAD ADLPPNELHF QLTALPRHGR IIQQLATGSQ
1260 1270 1280 1290 1300
PIHSFTLKEI QEASTIVYEH DDSETKEDSF EVWLSDGKHT THRKVPIVVT
1310 1320 1330 1340 1350
LVDDETPHLT VNNGLKVEKG HSEIITNRIL KATDLDSDDK SLSFVLHSGP
1360 1370 1380 1390 1400
QQGLLQRLRK PRGEVRNNLT LGMNFTQDEI NRGLICYIHT GQEGIVDIIK
1410 1420 1430 1440 1450
FDVTDGVNTL TDHYFYVTIG NLDSVFPEVI SKRITLIEGA RVTLTNNLLT
1460 1470 1480 1490 1500
NSDINSSDEH HFSITRAPSL GHLESSDYAG EPIASFTQLQ LASNKISYVH
1510 1520 1530 1540 1550
TSNDEKKMDS FEFQVIGELY PVFRTFRIFI TDVDNKKPIL TIHRLTLQKE
1560 1570 1580 1590 1600
DSQLITLLEL TVEDSDTPDD LILFTITQVP MHGKILYNGS RPVTTFTKQD
1610 1620 1630 1640 1650
LNKNLISYKH DGSETTEDSF SLTVTDGTHT DFYVLPDTAL ATHKPQVMRV
1660 1670 1680 1690 1700
QIRSLDNRLP QITTNRGAPA LKRLHTGHMG FLITSKSLKA EDQDSPHRLL
1710 1720 1730 1740 1750
KYKVTRGPEH GFIIKTGLGN QSTRVFTQAD IDEMKISYVL NEGSNASKDI
1760 1770 1780 1790 1800
FYFSVEDNGG NKLTNQPFHL NWAWICLEKE YYIVDEDSTF LEVTLTRRGY
1810 1820 1830 1840 1850
LGETSFISIG TKDETAKKDK DFKWKTNKQI QFNPGQTTAT WRVRIIPDNE
1860 1870 1880 1890 1900
YETSETFQII LSEPLMAVLE FPEMATVEIV DPGDESTVYI PEAEYKIEED
1910 1920 1930 1940 1950
IGELLIPVRR SGDASQELIV ICSTRQGSAT GTISSTVLFS DYISRPEDHT
1960 1970 1980 1990 2000
SILHFDKNET QKTCQVLIID DSLYEEEESF SVSLRLPVGG QLGARFPTTK
2010 2020 2030 2040 2050
VTILADRYDE PVLHFGDAEY HVNESARYVE VCVWRRGTDL SQPSSIAVRS
2060 2070 2080 2090 2100
RKSEQESAEA GTDYVGISRN LDFAPGVRMQ TFQVTILDDL GQPTLEGPEK
2110 2120 2130
FELLLQMPMG AVLGEPNKTT IFIEDTITDC KQSACSSFD
Length:2,139
Mass (Da):238,179
Last modified:November 16, 2011 - v2
Checksum:i0F086CB8AFB64E9C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055819412D → N. Corresponds to variant dbSNP:rs4478130Ensembl.1
Natural variantiVAR_059291417D → N. Corresponds to variant dbSNP:rs184496Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139713 Genomic DNA No translation available.
CCDSiCCDS54808.1
RefSeqiNP_001161707.1, NM_001168235.1
UniGeneiHs.252714

Genome annotation databases

EnsembliENST00000329798; ENSP00000332886; ENSG00000183090
GeneIDi166752
KEGGihsa:166752
UCSCiuc021xsj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFREM3_HUMAN
AccessioniPrimary (citable) accession number: P0C091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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