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Protein

FRAS1-related extracellular matrix protein 3

Gene

FREM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular matrix protein which may play a role in cell adhesion.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: BHF-UCL
  • cell communication Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 3
Gene namesi
Name:FREM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25172. FREM3.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: BHF-UCL
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiFREM3.
DMDMi357528797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 21392109FRAS1-related extracellular matrix protein 3PRO_0000010127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence analysis
Glycosylationi1368 – 13681N-linked (GlcNAc...)Sequence analysis
Glycosylationi1374 – 13741N-linked (GlcNAc...)Sequence analysis
Glycosylationi1588 – 15881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0C091.
PRIDEiP0C091.

PTM databases

PhosphoSiteiP0C091.

Expressioni

Gene expression databases

BgeeiP0C091.
CleanExiHS_FREM3.
GenevisibleiP0C091. HS.

Organism-specific databases

HPAiHPA041641.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332886.

Structurei

3D structure databases

ProteinModelPortaliP0C091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati285 – 413129CSPG 1Add
BLAST
Repeati414 – 524111CSPG 2Add
BLAST
Repeati525 – 683159CSPG 3Add
BLAST
Repeati684 – 811128CSPG 4Add
BLAST
Repeati812 – 922111CSPG 5Add
BLAST
Repeati923 – 1055133CSPG 6Add
BLAST
Repeati1056 – 1174119CSPG 7Add
BLAST
Repeati1175 – 1287113CSPG 8Add
BLAST
Repeati1288 – 1405118CSPG 9Add
BLAST
Repeati1406 – 1518113CSPG 10Add
BLAST
Repeati1519 – 1636118CSPG 11Add
BLAST
Repeati1637 – 1763127CSPG 12Add
BLAST
Domaini1764 – 186299Calx-beta 1Add
BLAST
Domaini1875 – 1985111Calx-beta 2Add
BLAST
Domaini2000 – 2106107Calx-beta 3Add
BLAST

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated
Contains 3 Calx-beta domains.Curated
Contains 12 CSPG (NG2) repeats.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
KOG3597. Eukaryota.
ENOG41112TU. LUCA.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000007464.
HOVERGENiHBG081538.
InParanoidiP0C091.
OMAiWLSDGKH.
OrthoDBiEOG751NDJ.
PhylomeDBiP0C091.
TreeFamiTF316876.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR032833. FREM3.
[Graphical view]
PANTHERiPTHR11878:SF31. PTHR11878:SF31. 2 hits.
PfamiPF03160. Calx-beta. 3 hits.
[Graphical view]
SMARTiSM00237. Calx_beta. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASRHPTG TPRQLLVALA CLLLSRPALQ GRASSLGTEP DPALYLPARG
60 70 80 90 100
ALDGTRPDGP SVLIANPGLR VPLGRSLWLD PLRDLVIGVQ PGDRCEVTVL
110 120 130 140 150
DALPRLKGAL SPRRFPCTFG PRQVQYTHFG SHSPGRARVL LQLRYDAPTH
160 170 180 190 200
TLVLPFTLAV DLVFSQLELV TRNRPLVVEK LRSWSRAIDR RVLDFASLKS
210 220 230 240 250
GATATRRCRL TPLPHEDGPL PKYGRLVDAV GAPLPRGKGV DCEAFLRAGV
260 270 280 290 300
RYQHTATSSP NRDYVPMMVE LLGPEGQDAG SAGVLVREHF QLLVRIRGGA
310 320 330 340 350
ENTPPRPSFM ATMMMEVDPL VLTALTPDAL AAEDVESDPG DLVFNILNAP
360 370 380 390 400
THPPGHPGQQ GYVVSTDDPL GLPVSFFTQQ ELRELKIAYQ PPAENSHGER
410 420 430 440 450
LFQLELEVVD GDGAASDPFA FMVTVKSMNT LVPVASHNRG LVLFEGQSRP
460 470 480 490 500
LSSTHSIPIS DKDNLEEVKM AAVRGLRHGQ LVVFGAPAGC KYFTPADLAA
510 520 530 540 550
GRVVYQHDGS NTYSDNIIFR MEDGHHQVDF LFPLTILPVD DEPPMVNTNT
560 570 580 590 600
GLSLTEGQVV QISPFVLSAT DIDSEDSTIH FVLENQPLKG NEEEPQWELA
610 620 630 640 650
PGSSHSGHYL GDLLLQQAEL PLSTEDEDWH YMEKEGLYEK VVTEWLQRDI
660 670 680 690 700
MEGRLFYRHL GPHSPQSVMV QLAFHVQDDH DPPNLSKQHI FTIKVQPVDI
710 720 730 740 750
LSPQLYPGTT LEMTVQEYQL THFQKNFLRY IDQDSDDQNL WYTLLTLPTD
760 770 780 790 800
TDGNHQVRAG EIVLTDSPDT LIMHFTQAQV NQHKVAYQPP QKLGIAPRVV
810 820 830 840 850
QFTYQVEDAA GNSVPGTFTL FLQPVDNQPP EVTNRGFAIL EGGSFNLSSN
860 870 880 890 900
ELHVTDPDTD IDQIVFILVR GPQHGHLQYF KRCMVPGESF MQADVINGSV
910 920 930 940 950
SYQHGRDQTT TSDTFHLEVS DGVHHIPITI PISVHPNVAN RSPRISLRSS
960 970 980 990 1000
SLLDVSIDVL ENKATEITMG VIHGKRKDVG DLMLSFIVKD SPKLGTILVN
1010 1020 1030 1040 1050
GLPTERFTQE DLINGRVAYA HTAGEVGFQK QHDAFSLILS KDSYQWVVGN
1060 1070 1080 1090 1100
SIIEKVQVQV TVLPVDNVGP KVFVGESFIV YEGEKNSLTL QHLHVEDVDT
1110 1120 1130 1140 1150
HQDELLCTVT SQPASGYLEK IASAPGSKMS QSGSPISAFS LRDIQVRHIN
1160 1170 1180 1190 1200
YVQSIHKGVE PQEDQFTFYC SDGINFSPNV FFPIIILPTN DEQPKLFAHE
1210 1220 1230 1240 1250
FKVLEGMSLV IDTQLLNGAD ADLPPNELHF QLTALPRHGR IIQQLATGSQ
1260 1270 1280 1290 1300
PIHSFTLKEI QEASTIVYEH DDSETKEDSF EVWLSDGKHT THRKVPIVVT
1310 1320 1330 1340 1350
LVDDETPHLT VNNGLKVEKG HSEIITNRIL KATDLDSDDK SLSFVLHSGP
1360 1370 1380 1390 1400
QQGLLQRLRK PRGEVRNNLT LGMNFTQDEI NRGLICYIHT GQEGIVDIIK
1410 1420 1430 1440 1450
FDVTDGVNTL TDHYFYVTIG NLDSVFPEVI SKRITLIEGA RVTLTNNLLT
1460 1470 1480 1490 1500
NSDINSSDEH HFSITRAPSL GHLESSDYAG EPIASFTQLQ LASNKISYVH
1510 1520 1530 1540 1550
TSNDEKKMDS FEFQVIGELY PVFRTFRIFI TDVDNKKPIL TIHRLTLQKE
1560 1570 1580 1590 1600
DSQLITLLEL TVEDSDTPDD LILFTITQVP MHGKILYNGS RPVTTFTKQD
1610 1620 1630 1640 1650
LNKNLISYKH DGSETTEDSF SLTVTDGTHT DFYVLPDTAL ATHKPQVMRV
1660 1670 1680 1690 1700
QIRSLDNRLP QITTNRGAPA LKRLHTGHMG FLITSKSLKA EDQDSPHRLL
1710 1720 1730 1740 1750
KYKVTRGPEH GFIIKTGLGN QSTRVFTQAD IDEMKISYVL NEGSNASKDI
1760 1770 1780 1790 1800
FYFSVEDNGG NKLTNQPFHL NWAWICLEKE YYIVDEDSTF LEVTLTRRGY
1810 1820 1830 1840 1850
LGETSFISIG TKDETAKKDK DFKWKTNKQI QFNPGQTTAT WRVRIIPDNE
1860 1870 1880 1890 1900
YETSETFQII LSEPLMAVLE FPEMATVEIV DPGDESTVYI PEAEYKIEED
1910 1920 1930 1940 1950
IGELLIPVRR SGDASQELIV ICSTRQGSAT GTISSTVLFS DYISRPEDHT
1960 1970 1980 1990 2000
SILHFDKNET QKTCQVLIID DSLYEEEESF SVSLRLPVGG QLGARFPTTK
2010 2020 2030 2040 2050
VTILADRYDE PVLHFGDAEY HVNESARYVE VCVWRRGTDL SQPSSIAVRS
2060 2070 2080 2090 2100
RKSEQESAEA GTDYVGISRN LDFAPGVRMQ TFQVTILDDL GQPTLEGPEK
2110 2120 2130
FELLLQMPMG AVLGEPNKTT IFIEDTITDC KQSACSSFD
Length:2,139
Mass (Da):238,179
Last modified:November 16, 2011 - v2
Checksum:i0F086CB8AFB64E9C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti412 – 4121D → N.
Corresponds to variant rs4478130 [ dbSNP | Ensembl ].
VAR_055819
Natural varianti417 – 4171D → N.
Corresponds to variant rs184496 [ dbSNP | Ensembl ].
VAR_059291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139713 Genomic DNA. No translation available.
CCDSiCCDS54808.1.
RefSeqiNP_001161707.1. NM_001168235.1.
UniGeneiHs.252714.

Genome annotation databases

EnsembliENST00000329798; ENSP00000332886; ENSG00000183090.
GeneIDi166752.
KEGGihsa:166752.
UCSCiuc021xsj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139713 Genomic DNA. No translation available.
CCDSiCCDS54808.1.
RefSeqiNP_001161707.1. NM_001168235.1.
UniGeneiHs.252714.

3D structure databases

ProteinModelPortaliP0C091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332886.

PTM databases

PhosphoSiteiP0C091.

Polymorphism and mutation databases

BioMutaiFREM3.
DMDMi357528797.

Proteomic databases

PaxDbiP0C091.
PRIDEiP0C091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329798; ENSP00000332886; ENSG00000183090.
GeneIDi166752.
KEGGihsa:166752.
UCSCiuc021xsj.2. human.

Organism-specific databases

CTDi166752.
GeneCardsiFREM3.
HGNCiHGNC:25172. FREM3.
HPAiHPA041641.
MIMi608946. gene.
neXtProtiNX_P0C091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
KOG3597. Eukaryota.
ENOG41112TU. LUCA.
GeneTreeiENSGT00550000074429.
HOGENOMiHOG000007464.
HOVERGENiHBG081538.
InParanoidiP0C091.
OMAiWLSDGKH.
OrthoDBiEOG751NDJ.
PhylomeDBiP0C091.
TreeFamiTF316876.

Miscellaneous databases

GenomeRNAii166752.
NextBioi88613.
PROiP0C091.
SOURCEiSearch...

Gene expression databases

BgeeiP0C091.
CleanExiHS_FREM3.
GenevisibleiP0C091. HS.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR032833. FREM3.
[Graphical view]
PANTHERiPTHR11878:SF31. PTHR11878:SF31. 2 hits.
PfamiPF03160. Calx-beta. 3 hits.
[Graphical view]
SMARTiSM00237. Calx_beta. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis."
    Smyth I., Du X., Taylor M.S., Justice M.J., Beutler B., Jackson I.J.
    Proc. Natl. Acad. Sci. U.S.A. 101:13560-13565(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiFREM3_HUMAN
AccessioniPrimary (citable) accession number: P0C091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 16, 2011
Last modified: March 16, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.