Reviewed, UniProtKB/Swiss-Prot P0C075 (ATG8_CANAL)

Names and origin

Protein names

Recommended name:
    Autophagy-related protein 8
Alternative name(s):
    Autophagy-related ubiquitin-like modifier ATG8

Gene names

Name:	ATG8
ORF Names:	CaO19.2480.1, CaO19.10016.1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. May mediate the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton By similarity.
Subcellular location	Cytoplasmic vesicle › cvt vesicle membrane; Lipid-anchor By similarity. Cytoplasmic vesicle › autophagosome membrane; Lipid-anchor By similarity. Vacuole membrane; Lipid-anchor By similarity. Note: Membrane-associated through a lipid anchor By similarity.
Post-translational modification	The C-terminal 19 residues are removed to expose Gly-116 at the C-terminus. The carboxyl-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport Ubl conjugation pathway
Cellular component	Cytoplasmic vesicle Membrane Vacuole
PTM	Lipoprotein
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW vacuole Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Autophagy-related protein 8		PRO_0000017210
	Propeptide	117 – 135	19	Removed in mature form By similarity		PRO_0000017211
Amino acid modifications
	Lipidation	116	1	Phosphatidylethanolamine amidated glycine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C075-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: A5D1B50B0669AF6A	FASTA	135	15,643
	10 20 30 40 50 60 MRSQFKDEHP FEKRQAEAAR IAQRFKDRVP VICEKVENSD IPEIDKRKYL VPVDLTVGQF 70 80 90 100 110 120 VYVIRKRIKL PSEKAIFIFV NDILPPTAAL ISTIYEEHKD EDGFLYVLYS GENTFGEKLA 130 IDISSLDFSD IPDYV

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACQ01000041 Genomic DNA. No translation available. AACQ01000040 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Organism-specific databases
CGD	CAF0006954. AUT7.
Phylogenomic databases
OMA	VICEKVE.
OrthoDB	EOG9ZKM3X.
Family and domain databases
InterPro	IPR004241. MAP1_LC3. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. MAP1_LC3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG8_CANAL

Accession

Primary (citable) accession number: P0C075

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)