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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to antibiotic Source: EcoCyc
  • cellular response to oxidative stress Source: EcoCyc
  • cell wall macromolecule catabolic process Source: UniProtKB-HAMAP
  • cell wall organization Source: UniProtKB-KW
  • peptidoglycan metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:G7533-MONOMER.
ECOL316407:JW5481-MONOMER.
MetaCyc:G7533-MONOMER.

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Synonyms:yggZ
Ordered Locus Names:b2963, JW5481
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12986. mltC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 359343Membrane-bound lytic murein transglycosylase CPRO_0000032785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi17 – 171N-palmitoyl cysteineUniRule annotation
Lipidationi17 – 171S-diacylglycerol cysteineUniRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0C066.
PRIDEiP0C066.

Expressioni

Inductioni

By SoxS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262361. 451 interactions.
STRINGi511145.b2963.

Structurei

Secondary structure

1
359
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 5217Combined sources
Helixi54 – 563Combined sources
Beta strandi62 – 698Combined sources
Turni70 – 734Combined sources
Beta strandi74 – 796Combined sources
Turni80 – 834Combined sources
Beta strandi84 – 896Combined sources
Helixi95 – 10814Combined sources
Helixi113 – 1153Combined sources
Beta strandi120 – 1223Combined sources
Beta strandi129 – 1313Combined sources
Beta strandi140 – 1423Combined sources
Helixi148 – 16114Combined sources
Beta strandi164 – 1674Combined sources
Beta strandi169 – 17911Combined sources
Helixi184 – 1907Combined sources
Helixi193 – 20311Combined sources
Helixi207 – 21812Combined sources
Turni232 – 2354Combined sources
Turni238 – 2403Combined sources
Helixi241 – 2477Combined sources
Turni248 – 2503Combined sources
Helixi257 – 2604Combined sources
Helixi263 – 27917Combined sources
Turni280 – 2845Combined sources
Helixi288 – 30114Combined sources
Helixi303 – 3075Combined sources
Turni308 – 3103Combined sources
Helixi314 – 3218Combined sources
Helixi326 – 33510Combined sources
Helixi340 – 35718Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5FX-ray2.34A/B20-359[»]
4CFOX-ray2.90A/B20-359[»]
4CFPX-ray2.15A/B20-359[»]
4CHXX-ray2.45A/B20-359[»]
ProteinModelPortaliP0C066.
SMRiP0C066. Positions 33-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0C066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYLALALI APLLISCSTT KKGDTYNEAW VKDTNGFDIL MGQFAHNIEN
60 70 80 90 100
IWGFKEVVIA GPKDYVKYTD QYQTRSHINF DDGTITIETI AGTEPAAHLR
110 120 130 140 150
RAIIKTLLMG DDPSSVDLYS DVDDITISKE PFLYGQVVDN TGQPIRWEGR
160 170 180 190 200
ASNFADYLLK NRLKSRSNGL RIIYSVTINM VPNHLDKRAH KYLGMVRQAS
210 220 230 240 250
RKYGVDESLI LAIMQTESSF NPYAVSRSDA LGLMQVVQHT AGKDVFRSQG
260 270 280 290 300
KSGTPSRSFL FDPASNIDTG TAYLAMLNNV YLGGIDNPTS RRYAVITAYN
310 320 330 340 350
GGAGSVLRVF SNDKIQAANI INTMTPGDVY QTLTTRHPSA ESRRYLYKVN

TAQKSYRRR
Length:359
Mass (Da):40,113
Last modified:July 19, 2005 - v1
Checksum:i618F0FCC9C41969C
GO

Sequence cautioni

The sequence AAA69130 differs from that shown. Reason: Frameshift at position 166. Curated
The sequence AAA69130 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA69131 differs from that shown. Reason: Frameshift at position 166. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69130.1. Sequence problems.
U28377 Genomic DNA. Translation: AAA69131.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76000.2.
AP009048 Genomic DNA. Translation: BAE77026.1.
U59902 Genomic DNA. Translation: AAC44296.1.
PIRiB65082.
RefSeqiNP_417438.2. NC_000913.3.
WP_000760323.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76000; AAC76000; b2963.
BAE77026; BAE77026; BAE77026.
GeneIDi945428.
KEGGiecj:JW5481.
eco:b2963.
PATRICi32121340. VBIEscCol129921_3058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69130.1. Sequence problems.
U28377 Genomic DNA. Translation: AAA69131.1. Frameshift.
U00096 Genomic DNA. Translation: AAC76000.2.
AP009048 Genomic DNA. Translation: BAE77026.1.
U59902 Genomic DNA. Translation: AAC44296.1.
PIRiB65082.
RefSeqiNP_417438.2. NC_000913.3.
WP_000760323.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5FX-ray2.34A/B20-359[»]
4CFOX-ray2.90A/B20-359[»]
4CFPX-ray2.15A/B20-359[»]
4CHXX-ray2.45A/B20-359[»]
ProteinModelPortaliP0C066.
SMRiP0C066. Positions 33-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262361. 451 interactions.
STRINGi511145.b2963.

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Proteomic databases

PaxDbiP0C066.
PRIDEiP0C066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76000; AAC76000; b2963.
BAE77026; BAE77026; BAE77026.
GeneIDi945428.
KEGGiecj:JW5481.
eco:b2963.
PATRICi32121340. VBIEscCol129921_3058.

Organism-specific databases

EchoBASEiEB2810.
EcoGeneiEG12986. mltC.

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.

Enzyme and pathway databases

BioCyciEcoCyc:G7533-MONOMER.
ECOL316407:JW5481-MONOMER.
MetaCyc:G7533-MONOMER.

Miscellaneous databases

PROiP0C066.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLTC_ECOLI
AccessioniPrimary (citable) accession number: P0C066
Secondary accession number(s): P52066
, P71274, P76651, P76652, Q2M9N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.