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Protein

Small heat shock protein IbpA

Gene

ibpA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.UniRule annotation

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpAUniRule annotation
Alternative name(s):
16 kDa heat shock protein AUniRule annotation
Gene namesi
Name:ibpAUniRule annotation
Ordered Locus Names:Z5183, ECs4627
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260181 – 137Small heat shock protein IbpAAdd BLAST137

Interactioni

Subunit structurei

Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z5183

Structurei

3D structure databases

ProteinModelPortaliP0C055
SMRiP0C055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 137sHSPPROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZNX Bacteria
COG0071 LUCA
HOGENOMiHOG000251750
KOiK04080
OMAiTAHDNML

Family and domain databases

CDDicd06470 ACD_IbpA-B_like, 1 hit
Gene3Di2.60.40.790, 1 hit
HAMAPiMF_02000 HSP20_IbpA, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037913 ACD_IbpA/B
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
IPR023728 HSP20_IbpA
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P0C055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFDLSPLY RSAIGFDRLF NHLENNQSQS NGGYPPYNVE LVDENHYRIA
60 70 80 90 100
IAVAGFAESE LEITAQDNLL VVKGAHADEQ KERTYLYQGI AERNFERKFQ
110 120 130
LAENIHVRGA NLVNGLLYID LERVIPEAKK PRRIEIN
Length:137
Mass (Da):15,774
Last modified:July 5, 2005 - v1
Checksum:iE7BB51421F5CEF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG58889.1
BA000007 Genomic DNA Translation: BAB38050.1
PIRiC91207
E86053
RefSeqiNP_312654.1, NC_002695.1
WP_001243437.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG58889; AAG58889; Z5183
BAB38050; BAB38050; BAB38050
GeneIDi915409
KEGGiece:Z5183
ecs:ECs4627
PATRICifig|386585.9.peg.4834

Similar proteinsi

Entry informationi

Entry nameiIBPA_ECO57
AccessioniPrimary (citable) accession number: P0C055
Secondary accession number(s): P29209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health