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Protein

ESAT-6 secretion machinery protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ESAT-6 secretion system (Ess) (Probable). Required for the secretion of EsxA and EsxB (PubMed:15657139).Curated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi672 – 679ATPPROSITE-ProRule annotation8
Nucleotide bindingi1014 – 1021ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6 secretion machinery protein EssCCurated
Gene namesi
Name:essC1 Publication
Ordered Locus Names:NWMN_0223
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229Cytoplasmic1 PublicationAdd BLAST229
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23
Topological domaini253 – 256Extracellular1 Publication4
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Topological domaini280 – 1479Cytoplasmic1 PublicationAdd BLAST1200

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutations abolish synthesis and secretion of both EsxA and EsxB, without affecting their transcription. Mutant shows a significant reduction in the ability to establish kidney or liver abscesses in infected mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000983341 – 1479ESAT-6 secretion machinery protein EssCAdd BLAST1479

Structurei

3D structure databases

ProteinModelPortaliP0C048.
SMRiP0C048.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 846FtsK 1PROSITE-ProRule annotationAdd BLAST195
Domaini997 – 1183FtsK 2PROSITE-ProRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the EssC family.Curated
Contains 2 FtsK domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C048-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGPNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQESQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSTVTI VFGITTYFSE KKKYNKDVEK REKDYKAYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSTFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSRSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGIA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRIF NDEIDRRKKI LSQYRVTSIS
1110 1120 1130 1140 1150
EYRKLTGETI PHVFILIDNF DAVKDSPFQE VFENMMIKMT REGLALDMQV
1160 1170 1180 1190 1200
TLTASRANAM KTPMYINMKT RIAMFLYDKS EVSNVVGQQK FAVKDVVGRA
1210 1220 1230 1240 1250
LLSSDDNVSF HIGQPFKHDE TKSYNDQIND EVSAMTEFYK GETPNDIPMM
1260 1270 1280 1290 1300
PDEIKYEDYR ESLNLPDIVA NGALPIGLDY EGVTLQKIKL TEPAMISSEN
1310 1320 1330 1340 1350
PREIAHIAEI MMKEIDILNE KYAICIADSS GEFKAYRHQV ANFAEEREDI
1360 1370 1380 1390 1400
KAIHQLMIED LKQREMDGPF EKDSLYIIND FKTFIDCTYI PEDDVKKLIT
1410 1420 1430 1440 1450
KGPELGLNIL FVGIHKELID AYDKQIDVAR KMINQFSIGI RISDQQFFKF
1460 1470
RFIQREPVIK ENEAYMVANQ AYQKIRWFK
Length:1,479
Mass (Da):170,931
Last modified:January 15, 2008 - v2
Checksum:i0EC13F663848BBCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF66495.1.
RefSeqiWP_000549278.1. NC_009641.1.

Genome annotation databases

EnsemblBacteriaiBAF66495; BAF66495; NWMN_0223.
GeneIDi28379391.
KEGGisae:NWMN_0223.
PATRICi19583792. VBIStaAur133992_0239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009351 Genomic DNA. Translation: BAF66495.1.
RefSeqiWP_000549278.1. NC_009641.1.

3D structure databases

ProteinModelPortaliP0C048.
SMRiP0C048.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF66495; BAF66495; NWMN_0223.
GeneIDi28379391.
KEGGisae:NWMN_0223.
PATRICi19583792. VBIStaAur133992_0239.

Phylogenomic databases

HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESSC_STAAE
AccessioniPrimary (citable) accession number: P0C048
Secondary accession number(s): A6QDR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.