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P0C045 (F_HCVH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
F protein
Alternative name(s):
Alternate reading frame protein/F-protein
Short name=ARFP/F
Frameshifted protein
p16
p17
OrganismHepatitis C virus genotype 1a (isolate H) (HCV) [Reference proteome]
Taxonomic identifier11108 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Host cytoplasm. Host cytoplasmhost perinuclear region Ref.3.

Miscellaneous

This protein is very unstable.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   Coding sequence diversityRibosomal frameshifting
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]

Note: The exact location of the ribosomal frameshift is unknown. The F protein seems to be generated by a -2 ribosomal frameshift located in the vicinity of codon 11 of the core protein coding sequence. However, some F proteins may also be generated by +1 ribosomal frameshift. Since the core gene encodes alternative reading frame proteins (ARFPs), many functions depicted for the core protein might belong to the ARFPs.
Isoform F protein (identifier: P0C045-1)

Also known as: Frameshifted protein;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by ribosomal frameshifting.
Isoform Genome polyprotein (identifier: P27958-1)

The sequence of this isoform can be found in the external entry P27958.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by conventional translation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host By similarity
Chain2 – 162161F protein
PRO_0000109553

Sequences

Sequence LengthMass (Da)Tools
Isoform F protein (Frameshifted protein) [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AE9D5391D19211B6

FASTA16217,006
        10         20         30         40         50         60 
MSTNPKPQRK KPNVTPTVAH RTSSSRVAVR SLVEFTCCRA GALDWVCARR GRLPSGRNLE 

        70         80         90        100        110        120 
VDVSLSPRHV GPRAGPGLSP GTLGPSMAMR VAGGRDGSCL PVALGLAGAP QTPGVGRAIW 

       130        140        150        160 
VRSSIPLRAA SPTSWGTYRS SAPLLEALPG PWRMASGFWK TA 

« Hide

Isoform Genome polyprotein [UniParc].

See P27958.

References

[1]"Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates."
Inchauspe G., Zebedee S., Lee D.H.H., Sugitani M., Nasoff M., Prince A.M.
Proc. Natl. Acad. Sci. U.S.A. 88:10292-10296(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA."
Kolykhalov A.A., Agapov E.V., Blight K.J., Mihalik K., Feinstone S.M., Rice C.M.
Science 277:570-574(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Strain: Isolate H77.
[3]"Characterization of the expression of the hepatitis C virus F protein."
Roussel J., Pillez A., Montpellier C., Duverlie G., Cahour A., Dubuisson J., Wychowski C.
J. Gen. Virol. 84:1751-1759(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[4]"The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others."
Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L.
Semin. Liver Dis. 25:105-117(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M67463 Genomic RNA. No translation available.
AF009606 Genomic RNA. No translation available.

3D structure databases

ProteinModelPortalP0C045.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

euHCVdbAF009606.
M67463.

Family and domain databases

InterProIPR002522. HCV_core_N.
[Graphical view]
PfamPF01543. HCV_capsid. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF_HCVH
AccessionPrimary (citable) accession number: P0C045
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program