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P0C045

- F_HCVH

UniProt

P0C045 - F_HCVH

Protein

F protein

Gene
N/A
Organism
Hepatitis C virus genotype 1a (isolate H) (HCV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F protein
    Alternative name(s):
    Alternate reading frame protein/F-protein
    Short name:
    ARFP/F
    Frameshifted protein
    p16
    p17
    OrganismiHepatitis C virus genotype 1a (isolate H) (HCV)
    Taxonomic identifieri11108 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000518: Genome

    Subcellular locationi

    Host cytoplasm 1 Publication. Host cytoplasmhost perinuclear region 1 Publication

    GO - Cellular componenti

    1. host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
    2. viral capsid Source: InterPro

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by hostBy similarity
    Chaini2 – 162161F proteinPRO_0000109553Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0C045.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR002522. HCV_core_N.
    [Graphical view]
    PfamiPF01543. HCV_capsid. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Note: The exact location of the ribosomal frameshift is unknown. The F protein seems to be generated by a -2 ribosomal frameshift located in the vicinity of codon 11 of the core protein coding sequence. However, some F proteins may also be generated by +1 ribosomal frameshift. Since the core gene encodes alternative reading frame proteins (ARFPs), many functions depicted for the core protein might belong to the ARFPs.

    Isoform F protein (identifier: P0C045-1) [UniParc]FASTAAdd to Basket

    Also known as: Frameshifted protein

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSTNPKPQRK KPNVTPTVAH RTSSSRVAVR SLVEFTCCRA GALDWVCARR    50
    GRLPSGRNLE VDVSLSPRHV GPRAGPGLSP GTLGPSMAMR VAGGRDGSCL 100
    PVALGLAGAP QTPGVGRAIW VRSSIPLRAA SPTSWGTYRS SAPLLEALPG 150
    PWRMASGFWK TA 162

    Note: Produced by ribosomal frameshifting.

    Length:162
    Mass (Da):17,006
    Last modified:January 23, 2007 - v2
    Checksum:iAE9D5391D19211B6
    GO
    Isoform Genome polyprotein (identifier: P27958-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P27958.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Produced by conventional translation.

    Length:3,011
    Mass (Da):327,146
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67463 Genomic RNA. No translation available.
    AF009606 Genomic RNA. No translation available.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M67463 Genomic RNA. No translation available.
    AF009606 Genomic RNA. No translation available.

    3D structure databases

    ProteinModelPortali P0C045.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    euHCVdbi AF009606.
    M67463.

    Family and domain databases

    InterProi IPR002522. HCV_core_N.
    [Graphical view ]
    Pfami PF01543. HCV_capsid. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates."
      Inchauspe G., Zebedee S., Lee D.H.H., Sugitani M., Nasoff M., Prince A.M.
      Proc. Natl. Acad. Sci. U.S.A. 88:10292-10296(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA."
      Kolykhalov A.A., Agapov E.V., Blight K.J., Mihalik K., Feinstone S.M., Rice C.M.
      Science 277:570-574(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
      Strain: Isolate H77.
    3. "Characterization of the expression of the hepatitis C virus F protein."
      Roussel J., Pillez A., Montpellier C., Duverlie G., Cahour A., Dubuisson J., Wychowski C.
      J. Gen. Virol. 84:1751-1759(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
    4. "The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others."
      Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L.
      Semin. Liver Dis. 25:105-117(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiF_HCVH
    AccessioniPrimary (citable) accession number: P0C045
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is very unstable.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3