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P0C044

- F_HCV1

UniProt

P0C044 - F_HCV1

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Protein

F protein

Gene
N/A
Organism
Hepatitis C virus genotype 1a (isolate 1) (HCV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
F protein
Alternative name(s):
Alternate reading frame protein/F-protein
Short name:
ARFP/F
Frameshifted protein
p16
p17
OrganismiHepatitis C virus genotype 1a (isolate 1) (HCV)
Taxonomic identifieri11104 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007410: Genome

Subcellular locationi

Host cytoplasm By similarity. Host cytoplasmhost perinuclear region By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. viral capsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by hostCurated
Chaini2 – 162161F proteinPRO_0000109552Add
BLAST

Family & Domainsi

Family and domain databases

InterProiIPR002522. HCV_core_N.
[Graphical view]
PfamiPF01543. HCV_capsid. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Note: The exact location of the ribosomal frameshift is unknown. The F protein seems to be generated by a -2 ribosomal frameshift located in the vicinity of codon 11 of the core protein coding sequence. However, some F proteins may also be generated by +1 ribosomal frameshift. Since the core gene encodes alternative reading frame proteins (ARFPs), many functions depicted for the core protein might belong to the ARFPs.1 Publication

Isoform F protein (identifier: P0C044-1) [UniParc]FASTAAdd to Basket

Also known as: Frameshifted protein

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTNPKPQKK KTNVTPTVAH RTSSSRVAVR SLVEFTCCRA GALDWVCARR
60 70 80 90 100
ERLPSGRNLE VDVSLSPRLV GPRAGPGLSP GTLGPSMAMR AAGGRDGSCL
110 120 130 140 150
PVALGLAGAP QTPGVGRAIW VRSSIPLRAA SPTSWGTYRS SAPLLEALPG
160
PWRMASGFWK TA

Note: Produced by ribosomal frameshifting.

Length:162
Mass (Da):17,002
Last modified:January 23, 2007 - v2
Checksum:i3DAD4DE1E4312A7A
GO
Isoform Genome polyprotein (identifier: P26664-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P26664.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by conventional translation.

Length:3,011
Mass (Da):327,202
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62321 Genomic RNA. No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62321 Genomic RNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

euHCVdbi M62321.

Family and domain databases

InterProi IPR002522. HCV_core_N.
[Graphical view ]
Pfami PF01543. HCV_capsid. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Synthesis of a novel hepatitis C virus protein by ribosomal frameshift."
    Xu Z., Choi J., Yen T.S.B., Lu W., Strohecker A., Govindarajan S., Chien D., Selby M.J., Ou J.-H.
    EMBO J. 20:3840-3848(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: RIBOSOMAL FRAMESHIFT, N-TERMINUS.
  3. "The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others."
    Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L.
    Semin. Liver Dis. 25:105-117(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiF_HCV1
AccessioniPrimary (citable) accession number: P0C044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is very unstable.By similarity

Keywords - Technical termi

Complete proteome

External Data

Dasty 3