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P0C044 (F_HCV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
F protein
Alternative name(s):
Alternate reading frame protein/F-protein
Short name=ARFP/F
Frameshifted protein
p16
p17
OrganismHepatitis C virus genotype 1a (isolate 1) (HCV) [Complete proteome]
Taxonomic identifier11104 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Host cytoplasm By similarity. Host cytoplasmhost perinuclear region By similarity.

Miscellaneous

This protein is very unstable By similarity.

Ontologies

Keywords
   Cellular componentHost cytoplasm
   Coding sequence diversityRibosomal frameshifting
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componenthost cell perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral capsid

Inferred from electronic annotation. Source: InterPro

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]

Note: The exact location of the ribosomal frameshift is unknown. The F protein seems to be generated by a -2 ribosomal frameshift located in the vicinity of codon 11 of the core protein coding sequence. However, some F proteins may also be generated by +1 ribosomal frameshift. Since the core gene encodes alternative reading frame proteins (ARFPs), many functions depicted for the core protein might belong to the ARFPs.
Isoform F protein (identifier: P0C044-1)

Also known as: Frameshifted protein;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Produced by ribosomal frameshifting.
Isoform Genome polyprotein (identifier: P26664-1)

The sequence of this isoform can be found in the external entry P26664.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by conventional translation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed; by host Probable
Chain2 – 162161F protein
PRO_0000109552

Sequences

Sequence LengthMass (Da)Tools
Isoform F protein (Frameshifted protein) [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3DAD4DE1E4312A7A

FASTA16217,002
        10         20         30         40         50         60 
MSTNPKPQKK KTNVTPTVAH RTSSSRVAVR SLVEFTCCRA GALDWVCARR ERLPSGRNLE 

        70         80         90        100        110        120 
VDVSLSPRLV GPRAGPGLSP GTLGPSMAMR AAGGRDGSCL PVALGLAGAP QTPGVGRAIW 

       130        140        150        160 
VRSSIPLRAA SPTSWGTYRS SAPLLEALPG PWRMASGFWK TA 

« Hide

Isoform Genome polyprotein [UniParc].

See P26664.

References

[1]"Genetic organization and diversity of the hepatitis C virus."
Choo Q.-L., Richman K.H., Han J.H., Berger K., Lee C., Dong C., Gallegos C., Coit D., Medina-Selby A., Barr P.J., Weiner A.J., Bradley D.W., Kuo G., Houghton M.
Proc. Natl. Acad. Sci. U.S.A. 88:2451-2455(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Synthesis of a novel hepatitis C virus protein by ribosomal frameshift."
Xu Z., Choi J., Yen T.S.B., Lu W., Strohecker A., Govindarajan S., Chien D., Selby M.J., Ou J.-H.
EMBO J. 20:3840-3848(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: RIBOSOMAL FRAMESHIFT, N-TERMINUS.
[3]"The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others."
Branch A.D., Stump D.D., Gutierrez J.A., Eng F., Walewski J.L.
Semin. Liver Dis. 25:105-117(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62321 Genomic RNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

euHCVdbM62321.

Family and domain databases

InterProIPR002522. HCV_core_N.
[Graphical view]
PfamPF01543. HCV_capsid. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF_HCV1
AccessionPrimary (citable) accession number: P0C044
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program