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Protein

Nucleoside diphosphate-linked moiety X motif 17

Gene

NUDT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi142 – 1421Magnesium or manganeseBy similarity
Metal bindingi146 – 1461Magnesium or manganeseBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 17 (EC:3.6.1.-)
Short name:
Nudix motif 17
Gene namesi
Name:NUDT17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26618. NUDT17.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890899.

Polymorphism and mutation databases

BioMutaiNUDT17.
DMDMi254763318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Nucleoside diphosphate-linked moiety X motif 17PRO_0000019953Add
BLAST

Proteomic databases

PaxDbiP0C025.
PRIDEiP0C025.

Expressioni

Gene expression databases

BgeeiP0C025.
CleanExiHS_NUDT17.
GenevisibleiP0C025. HS.

Organism-specific databases

HPAiHPA030145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334437.

Structurei

3D structure databases

ProteinModelPortaliP0C025.
SMRiP0C025. Positions 90-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 236147Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 14822Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVB3. Eukaryota.
ENOG4111BBY. LUCA.
GeneTreeiENSGT00390000013847.
HOGENOMiHOG000253927.
HOVERGENiHBG056751.
InParanoidiP0C025.
OMAiQRPPFCP.
PhylomeDBiP0C025.
TreeFamiTF313611.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVRVQLLL SRRPESVSFA RSVCGLLGAG PGLGTWPIHC SLKRGRLVLS
60 70 80 90 100
SRPFPGASAR LPLQRPPFCP FAALEERPRV PGAELPTDRG VDLGVAVILQ
110 120 130 140 150
SSDKTVLLTR RARTLSVSPN LWVPPGGHVE LEEELLDGGL RELWEESGLH
160 170 180 190 200
LPQGQFSWVP LGLWESAYPP RLSWGLPKYH HIVLYLLVIS QESQQQLQAR
210 220 230 240 250
IQPNPNEVSA LMWLTPDVAA AVAAAEDGTE TPGLLPQDLP PSVLAVELEE
260 270 280 290 300
DGRARPLVLH MSTLLRMIPT MAEDKERVST GTKFALKLWL QHLGRTPPPC
310 320
KSAAYLDPGP AKEEWNMDPL PPNQGSGK
Length:328
Mass (Da):35,923
Last modified:July 28, 2009 - v2
Checksum:iFD6FEF1EFB6E842D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160282 Genomic DNA. No translation available.
CCDSiCCDS72865.1.
RefSeqiNP_001012776.1. NM_001012758.2.
UniGeneiHs.585066.

Genome annotation databases

EnsembliENST00000334513; ENSP00000334437; ENSG00000186364.
GeneIDi200035.
KEGGihsa:200035.
UCSCiuc001eoe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160282 Genomic DNA. No translation available.
CCDSiCCDS72865.1.
RefSeqiNP_001012776.1. NM_001012758.2.
UniGeneiHs.585066.

3D structure databases

ProteinModelPortaliP0C025.
SMRiP0C025. Positions 90-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334437.

Polymorphism and mutation databases

BioMutaiNUDT17.
DMDMi254763318.

Proteomic databases

PaxDbiP0C025.
PRIDEiP0C025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334513; ENSP00000334437; ENSG00000186364.
GeneIDi200035.
KEGGihsa:200035.
UCSCiuc001eoe.4. human.

Organism-specific databases

CTDi200035.
GeneCardsiNUDT17.
HGNCiHGNC:26618. NUDT17.
HPAiHPA030145.
neXtProtiNX_P0C025.
PharmGKBiPA134890899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB3. Eukaryota.
ENOG4111BBY. LUCA.
GeneTreeiENSGT00390000013847.
HOGENOMiHOG000253927.
HOVERGENiHBG056751.
InParanoidiP0C025.
OMAiQRPPFCP.
PhylomeDBiP0C025.
TreeFamiTF313611.

Miscellaneous databases

GenomeRNAii200035.
NextBioi89817.
PROiP0C025.

Gene expression databases

BgeeiP0C025.
CleanExiHS_NUDT17.
GenevisibleiP0C025. HS.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiNUD17_HUMAN
AccessioniPrimary (citable) accession number: P0C025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 28, 2009
Last modified: March 16, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.